DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC22A3 and CarT

DIOPT Version :9

Sequence 1:	NP_068812.1	Gene:	SLC22A3 / 6581	HGNCID:	10967	Length:	556	Species:	Homo sapiens
Sequence 2:	NP_610052.1	Gene:	CarT / 35334	FlyBaseID:	FBgn0032879	Length:	674	Species:	Drosophila melanogaster

Alignment Length:	592	Identity:	186/592 - (31%)
Similarity:	287/592 - (48%)	Gaps:	60/592 - (10%)

- Green bases have known domain annotations that are detailed below.

Human     2 PSFDEA------LQRVGEFGRFQRRVFLLLCLTG-VTFAFLFVGVVFLGTQPDHYWCRGPSA--A 57
            ||.|||      |..:||||::|:.:...:||.. :...|.....:|:...||.||||.|..  .
  Fly    28 PSVDEAFDLDDLLPTIGEFGKYQKLLVFGICLPACIPCGFCAFNQLFMADTPDDYWCRIPELLDL 92

Human    58 ALAERCGWS-PEEEWNRTAPASRGPEPPERRGRCQRY------LLEAANDSASATSALSCADPLA 115
            .|.:|...| |:|..|.....|          :|..|      |||:..:....|..
  Fly    93 PLEQRKSLSIPKELDNDELVYS----------KCYTYGVNWTQLLESGEEDDLTTME-------- 139

Human   116 AFPNRSAPLVPCRGGWRY--AQAHSTIVSEFDLVCVNAWMLDLTQAILNLGFLTGAFTLGYAADR 178
              ||.|.||:.|..||.|  :...|:||.:|||||.......:..|.||.|...|.:..|...||
  Fly   140 --PNASWPLIKCPQGWEYNTSVVWSSIVIDFDLVCDQDIYPTIGLAALNTGGPVGVYLFGLLNDR 202

Human   179 YGRIVIYLLSCLGVGVTG-VVVAFAPNFPVFVIFRFLQGVFGKGTWMTCYVIVTEIVGSKQRRIV 242
            .||.:.|.: ||...:.| ::.:.:.:|..:...|.:.|:.....:...::|..|:||...|..|
  Fly   203 GGRRLSYFV-CLATLLAGSLMTSLSKDFWTWAGSRVIVGLTIPAVYQIPFIISLELVGENYRSFV 266

Human   243 GIVIQMFFTLGIIILPGIAYFIPNWQGIQLAITLPSFLFLLYYWVVPESPRWLITRKKGDKALQI 307
            .::...|:|.||::|.|:.|...:|..:....:||.:.:.||.:|:|||||||:.|.:.::||:|
  Fly   267 TVMTCTFYTSGIMLLSGVTYLERDWVRLSYITSLPFYAYFLYMFVMPESPRWLLMRGRLEEALKI 331

Human   308 LRRIAKCNGKYLSS----------NYSEITVTDEEVSNPSFLDLVRTPQMRKCTLILMFAWFTSA 362
            |.|:||.||:....          ...::....::::|....||.|||.||..|:::..:||.:.
  Fly   332 LERMAKVNGREFPEAVHLKLEAQIRRDKLKKQKKKMANVGLADLCRTPNMRLKTILITLSWFANE 396

Human   363 VVYQGLVMRLGIIGGNLYIDFFISGVVELPGALLILLTIERLGRRLPFAASNIVAGVACLVTAFL 427
            .||.||......:|.|.|:.||:|.|||||..|.....::..|||.|.:.|.|:.||||::|..|
  Fly   397 TVYLGLSYYGPALGTNQYVSFFLSAVVELPSYLCCWYFMDTWGRRWPLSLSMILGGVACVITVML 461

Human   428 PEGIAWLRTTVATLGRLGITMAFEIVYLVNSELYPTTLRNFGVSLCSGLCDFGGIIAPFLLFRLA 492
            |:........:..:.:..::.:|.|:|....|||||.:|..|:...|.:...|.|..||:.: |.
  Fly   462 PDDAVDETLVLYLVSKALLSASFLIIYPFAGELYPTQVRGIGIGASSYIGGLGLIGIPFITY-LG 525

Human   493 AVWLELPLIIFGILASICGGLVML-LPETKGIALPETVDDVEKLGS----PHSCKCGRNKK---T 549
            ...|:|||:|.|.| |:.||:..| ||||....||:|:::.|:.|.    ...|:|.:..:   .
  Fly   526 KDNLKLPLVIMGFL-SMLGGMTGLRLPETLHHRLPQTIEEGEEFGKNWQFKDCCRCAQKPEILSQ 589

Human   550 PVSRSHL 556
            |.|..:|
  Fly   590 PASYENL 596

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A3	NP_068812.1	2A0119	12..528	CDD:273328	172/539 (32%)
SLC22A3	NP_068812.1	MFS	149..518	CDD:119392	120/380 (32%)
CarT	NP_610052.1	2A0119	44..561	CDD:273328	172/539 (32%)
CarT	NP_610052.1	MFS	182..551	CDD:119392	120/371 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.920