Protein Alignment SLC22A1 and CG6356

DIOPT Version :10

• Sequence 1: XP_005267160.1
• Gene: SLC22A1 / 6580
• HGNCID: 10963
• Length: 573
• Species: Homo sapiens
• Sequence 2: NP_651240.1
• Gene: CG6356 / 42893
• FlyBaseID: FBgn0039178
• Length: 570
• Species: Drosophila melanogaster
• Alignment Length: 554
• Identity: 146/554 - (26%)
• Similarity: 238/554 - (42%)
• Gaps: 51/554 - (9%)

Human     8 LEQVGESGWFQKQAFLILCLLSAAFAPICV-GIVFLGFTPDHHCQSPGVAELSQRCGWSPAEELN 71
            ||.||..|.| ..|...||:.........| ....||..||.  |..|:.|| |...|:.|::..
  Fly    28 LEVVGSGGAF-VWAIFFLCVTPNILNGFHVSSYTLLGHLPDD--QWCGIPEL-QDTNWTHAQKRE 88

Human    72 YTVPGLGPAGEAFLGQCRRYEVDWNQSALSCVDPLASLATNRSHLPLGP-----CQDGWVYD--T 129
            ....||...|      |..:  |||...|:.:...|:|........:.|     |:....::  .
  Fly    89 IVAKGLDSGG------CTVW--DWNYGHLAKMSYEAALNYTGHLTQISPPAEVSCRVKGQHEFAH 145

Human   130 PGSSIVTEFNLVCADSWKLDLFQSCLNAGFLFGSLGVGYFADRFGRKLCL-LGTVLVNAVSGVLM 193
            |.::.|.:::|.|..|.:....|..::.|...||...|..||:||||... ||.... .|.....
  Fly   146 PETTFVADWDLTCDRSIQRTSAQVSISLGKFCGSFSFGILADKFGRKSSFTLGAAFF-IVGSFFC 209

Human   194 AFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSRRTVAIMYQMAFTVGLVALTGLAYAL 258
            .|||.|...|..|...|..|.|.:...:|:|.|.:....|..::|.:..::.||::.|..:.|.:
  Fly   210 TFSPWYSLFLAGRFALGAASSGLFYPAFTMIVENICLKHRSWMSIAFSASYPVGMIILAIVGYVI 274

Human   259 PHWRWLQLAVSLPTFLFLLYYWCVPESPRWLLSQKRNTEAIKIM----DHIAQKNGKLPP----A 315
            ..||.||||:::|:.|.:|..:.:.||||||::.:|.....||:    .|...:.....|    :
  Fly   275 QPWRHLQLALTIPSLLLILNCYLMSESPRWLITNQRYDRVYKILFRQPSHYQIQPAVAAPSQVAS 339

Human   316 DLKMLSLEEDVT--EKLS----PSFADLFRTPRLRKRTFILMYLWFTDSVLYQGLILHMGATSGN 374
            |.|.|..||..:  :||.    .|..:|:...::|:..|...:::...|:.|....|:....|.:
  Fly   340 DKKSLEPEEGFSFGQKLKNGPLKSIIELYANSKVRRMIFASYFMFCVTSLSYYVTALNAANLSVS 404

Human   375 LYLDFLYSALVEIPGAFIALITIDRVGRIYPMAMSNLLAGAACLVMIFI-SPDLHWLNIIIMCVG 438
            .||..:.:.||:||...:.:|.:...||........|..|.:.|:::.: :....|: :....:|
  Fly   405 RYLYIIGTGLVDIPSYLVPVIMLRFTGRRLTTMFLFLWTGVSLLLVLAVPAGSTTWI-VAFAMLG 468

Human   439 RMGITIAIQMICLVNAELYPTFVRNLGVMVCSSLCDIGGIITPFIVFRLREVWQALPLILFG--- 500
            |.||:....::.|..||||||.:||..:..||:...:|.|..|::|..|..:...:|..:.|
  Fly   469 RFGISATYSVVTLYTAELYPTQIRNSALGTCSTFAHVGSISAPYVVDVLGALGWYIPTTICGCCV 533

Human   501 ----------QRTSKTLLTHLIEDNSCWLFAEPA 524
                      ..|....|:..:|.::.....|||
  Fly   534 LVAGLLTLTLPETGTGKLSDKVESSASSTPTEPA 567

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A1	XP_005267160.1	2A0119	12..500	CDD:273328	136/511 (27%)
CG6356	NP_651240.1	MFS_SLC22	140..544	CDD:340875	107/405 (26%)