Protein Alignment SLC22A1 and Orct2

DIOPT Version :10

• Sequence 1: XP_005267160.1
• Gene: SLC22A1 / 6580
• HGNCID: 10963
• Length: 573
• Species: Homo sapiens
• Sequence 2: NP_651238.2
• Gene: Orct2 / 42890
• FlyBaseID: FBgn0086365
• Length: 567
• Species: Drosophila melanogaster
• Alignment Length: 530
• Identity: 166/530 - (31%)
• Similarity: 258/530 - (48%)
• Gaps: 50/530 - (9%)

Human     5 DDILEQVGESGWFQKQAFLILCLLSAAFAPICVGIVFLGFTPDHHCQSP----GVAELSQRCGWS 65
            |:.:..:|:.|.:||..:.::||.|...|...:..|||...||..|..|    ...:|.... |:
  Fly     4 DEAIIHLGDFGRYQKIIYFLICLTSIPVAFHKLAGVFLLAKPDFRCALPFENGSSYDLPTHL-WN 67

Human    66 PAEELNYTVPGLGPAGEAFLGQCRRYEVDWNQSALSCVDPLASLATNRSHLPLGPCQDGWVYDTP 130
                |:|      |..|    :|..|:||:.:..|:...|.:|..|.       .| ..:|||..
  Fly    68 ----LSY------PENE----RCSYYDVDYTEEYLNGSIPRSSNETK-------TC-SSYVYDRS 110

Human   131 G--SSIVTEFNLVCADSWKLDLFQSCLNAGFLFGSLGVGYFADRFGRKLCLLGTVLVNAVSGVLM 193
            .  :|.|||:||||...:......|....|.|.||:..|..:|::|||..|..::::..:.|||.
  Fly   111 KYLNSAVTEWNLVCGRDFMAATSDSLFMLGVLLGSIVFGQLSDKYGRKPILFASLVIQVLFGVLA 175

Human   194 AFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSRRTVAIMYQMAFTVGLVALTGLAYAL 258
            ..:|.|.:....||:.|..:.|.::..|.:..|.||...|....|...|.|:||.:.....||.:
  Fly   176 GVAPEYFTYTFARLMVGATTSGVFLVAYVVAMEMVGPDKRLYAGIFVMMFFSVGFMLTAVFAYFV 240

Human   259 PHWRWLQLAVSLPTFLFLLYYWCVPESPRWLLSQKRNTEAIKIMDHIAQKNGKLPPADLKMLSL- 322
            ..|||||:|::||..:|:.|||.:|||.||||.:.|...||..|...|:.| |:..:|..:..|
  Fly   241 HDWRWLQIALTLPGLIFMFYYWIIPESARWLLLKGRKDCAIANMQKAARFN-KVEISDEALSELL 304

Human   323 ------EEDVTEKLS---------PSFADLFRTPRLRKRTFILMYLWFTDSVLYQGLILHMGATS 372
                  ||...:||.         ||..|||..|.||::|.::...|...|.:|.||..:.....
  Fly   305 DEGENSEEKAKQKLEDQELDEGPPPSVWDLFCYPNLRRKTLLIFLDWLVTSGVYYGLSWNTSNLG 369

Human   373 GNLYLDFLYSALVEIPGAFIALITIDRVGRIYPMAMSNLLAGAACLVMIFISPDLHWLNIIIMCV 437
            ||:.|:|:.|..||||.....|:|::|.||...:....::||.:.|..:.|...:|.|.:....:
  Fly   370 GNVLLNFVISGAVEIPAYIFLLLTLNRWGRRSILCGCLVMAGLSLLATVIIPQRMHTLIVACAML 434

Human   438 GRMGITIAIQMICLVNAELYPTFVRNLGVMVCSSLCDIGGIITPFIVFRLREVWQALPLILFGQR 502
            |::.||.:...:.:.:||.:||.|||:.:...|.:..|.|::.||:.| |..:|:.|||::.|
  Fly   435 GKLAITASYGTVYIFSAEQFPTVVRNVALGAASMVARISGMMAPFLNF-LATIWKPLPLLICG-- 496

Human   503 TSKTLLTHLI 512
             |.||:..|:
  Fly   497 -SLTLVAGLL 505

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A1	XP_005267160.1	2A0119	12..500	CDD:273328	160/509 (31%)
Orct2	NP_651238.2	2A0119	11..520	CDD:273328	165/523 (32%)