Protein Alignment SLC22A1 and CG4459

DIOPT Version :10

• Sequence 1: XP_005267160.1
• Gene: SLC22A1 / 6580
• HGNCID: 10963
• Length: 573
• Species: Homo sapiens
• Sequence 2: NP_650850.1
• Gene: CG4459 / 42377
• FlyBaseID: FBgn0038753
• Length: 632
• Species: Drosophila melanogaster
• Alignment Length: 526
• Identity: 112/526 - (21%)
• Similarity: 215/526 - (40%)
• Gaps: 81/526 - (15%)

Human     6 DILEQV-GESGWFQKQAFLI--LCLL-SAAFAPICVGIVFLGFTPDHHCQSPGVAEL-SQRCGWS 65
            |::||| |..|.:|.:..|:  ||.: ||.|..|.:      :|..:    |...|| .....|:
  Fly    19 DVVEQVNGSFGRWQLRTILLIFLCKIPSAWFTAIII------YTAPY----PWKGELVCHPADWN 73

Human    66 PAEELNYTVPGLGPAGEAFLGQCRRYEVD--------------------WNQSALSCVDPLASLA 110
            .:......|....|..:......|.:.||                    ||.|
  Fly    74 VSRSQTEHVDRNHPLWQDARSTDRLFNVDVCNAYSNSLARGFVRSHGQEWNAS------------ 126

Human   111 TNRSHLPLG----PCQDGWVYDTPGSSIVTEFNLVCADSWKLDLFQSCLNAGFLFGSLGVGYFAD 171
              :|..|.|    ||:. ..:.|...|::::|:|:|:....:.|.||....|.|.|.| :.|.|.
  Fly   127 --QSKEPGGQSSLPCEH-VEHRTDYKSLISQFDLICSRRVLVALTQSFHALGALIGGL-MAYSAL 187

Human   172 R--FGRKLCLLGTVLVNAVSGVLMAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSRR 234
            :  ..|:|.||| ::.....|.|......|...:.||.|..:.....:.:|..::.:.....:|.
  Fly   188 KKISPRRLMLLG-MIGQIFCGNLTGLVDTYQLHIYFRCLTSIFCALMYTSGQFILNDITSGKARI 251

Human   235 TVAIMYQMAFTVGLVALTGLAYALPHWRWLQLAVSLPTFLFL-LYYWCVPESPRWLLSQKRNTEA 298
            .|..:.::.:::|||.|..::....:|.:|.:|:|....:.: |:.| :.::|||||..:|...|
  Fly   252 IVVTLSELFWSMGLVLLPAISIYFDNWSYLYVAISSSLIVLVWLHRW-IADAPRWLLQHQRVEAA 315

Human   299 IK-IMDHIAQKNGKLP---PADLKMLSLEEDVTEKLSPSFADLFRTPRLRKRTFILMYLWFTDSV 359
            :: :::.....|.|:|   ...|.|.:.:.|...|...|:..::.....|.:...:..:|....|
  Fly   316 LRQLLESATYNNRKVPLTLDVQLTMYANDLDQKSKQKHSYCQVWDGETKRSQLVYIHLIWGGAMV 380

Human   360 LYQGLIL---HMGATSGNLYLDFLYSALVEIPGAFIALITIDRVGRIYPMAMSNLLAGAACLVMI 421
            ||..::|   ::||.  .::::.......|:.|.|:.|..|....|.:..|.:.::.......:|
  Fly   381 LYNIILLMIRNLGAQ--QVHVNTAAMGFAEMVGLFVGLYLILYTRRHWRWAGNLMIIAGLSTYLI 443

Human   422 FISPDLH------WLNIIIMCVGRMGITIAIQMICLVNAELY---PTFVRNLGVMVCSSLCDIGG 477
            ::.|:..      .|.::...:.::..:.:|.::....:|:.   ...|..|.|:..|.:|   .
  Fly   444 WLLPETERNSRRVGLELVFWLILKIANSASIAVLTTCTSEIVSKEKRVVLMLSVISFSRVC---L 505

Human   478 IITPFI 483
            :..||:
  Fly   506 LFCPFL 511

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A1	XP_005267160.1	2A0119	12..500	CDD:273328	108/519 (21%)
CG4459	NP_650850.1	MFS_SLC22	139..540	CDD:340875	81/382 (21%)