Protein Alignment SLC22A1 and CG4462

DIOPT Version :10

• Sequence 1: XP_005267160.1
• Gene: SLC22A1 / 6580
• HGNCID: 10963
• Length: 573
• Species: Homo sapiens
• Sequence 2: NP_650849.1
• Gene: CG4462 / 42376
• FlyBaseID: FBgn0038752
• Length: 573
• Species: Drosophila melanogaster
• Alignment Length: 567
• Identity: 142/567 - (25%)
• Similarity: 237/567 - (41%)
• Gaps: 111/567 - (19%)

Human     5 DDILEQVGESGWFQKQAFLI--LCLLSAAFAPICVGIVFLGFTPDHHCQSPGVAELSQRCGWSPA 67
            |.|.:.||:.|.:|.:..||  ||.:.||:...|  |:|.|  |:.:   || :|.:  |
  Fly    41 DVIADVVGDFGIWQLRTILIIFLCKIPAAWFMAC--IIFTG--PELY---PG-SEFT--C----- 90

Human    68 EELNYTVPGLGPAGEAFLGQCRRYEVDWNQSALSCVDPLASLATNRSHLPLGPCQDGWVYDTPGS 132
             :.:|.......:......||  |.:|.:....|                  .|:. :.|.:...
  Fly    91 -DTSYLTSSSNSSFSISDNQC--YVLDESTGTSS------------------ECEQ-FNYVSSFD 133

Human   133 SIVTEFNLVCADSWKLDLFQSCLNAGFLFGSLGVGYFADRFGRKLCLLG-----TVLVNAVS--- 189
            |::.:|||||.    .|:|.:......|||.|..|.    .|.|: :||     |..|.||:
  Fly   134 SLIMQFNLVCL----RDIFVAWTQYWHLFGVLVGGV----MGTKM-MLGISPRSTYCVGAVAQIL 189

Human   190 -GVLMAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSRRTVAIMYQMAFTVGLVALTG 253
             ||:..::.::.....||.|..:.....:.||..:..:......|....|:|...:::|::.|.|
  Fly   190 CGVVTGYARDFSLHCAFRCLSAVCCAIMFTAGQAIFADITAGMHRIGAIILYDTFWSIGVILLPG 254

Human   254 LAYALPHWRWLQLAVSLPT-FLFLLYYWCVPESPRWLLSQKRNTEAIKIMDHIAQKNG------- 310
            |:.....|..:.:.::.|| .|.||.|| .|:||||||....:..:|..::.|.::..
  Fly   255 LSSFFNSWSLIYVGITFPTIMLILLLYW-TPDSPRWLLRHAADRFSIDNVEQILREGAAINDRSF 318

Human   311 KLPPADLKMLSLEEDVTEKLSPS-----FADLFRTPRLRKRTFILMYLWFTDSVL-YQGLILHMG 369
            |:||...:.|   |.::|:|...     :.:|::..| .|...:..:|.....|: :.|::|::
  Fly   319 KIPPDFRQQL---EQLSERLKAQPPPAPWTELWKGKR-AKTHMVAAHLALAFFVINFMGMLLNI- 378

Human   370 ATSGNLYL--DFLYSALVEIPGAFIAL-ITIDRVGRIYPMA-MSNLLAG-AACLVMIFISPDLH- 428
            .:.|..||  :.:.....||.|.|:|| .|:......:..| :.|:||| ..|:..||.:.|..
  Fly   379 RSFGRDYLVPNTIAMGFSEIIGCFLALHFTLKHNKWKWQCAGVFNILAGILGCMGWIFTNADSMD 443

Human   429 -------WLNIIIMCVGRMGITIAIQMICLVNAELYPTFVRNLGVMVCSSLCDIGGIITPFIVFR 486
                   |:  ||..:.:..::.|..||.....||.|...:.|.|....:...:..:..||...
  Fly   444 ADLKVSLWM--IIATIPKAAVSCAQSMILACMNELMPANKKQLFVFSVVTWARVWLLSAPFFNV- 505

Human   487 LREVWQALPL-------ILFGQRTSKTLLT----------HLIEDNS 516
            ||::..|:.|       ||.|..|| .|||          ||.:.|:
  Fly   506 LRKIDTAMSLTSYCVFSILGGICTS-LLLTPRLSVSPVVPHLEQRNT 551

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A1	XP_005267160.1	2A0119	12..500	CDD:273328	130/532 (24%)
CG4462	NP_650849.1	MFS_SLC22	123..533	CDD:340875	109/429 (25%)