Protein Alignment SLC22A1 and CG4465

DIOPT Version :10

• Sequence 1: XP_005267160.1
• Gene: SLC22A1 / 6580
• HGNCID: 10963
• Length: 573
• Species: Homo sapiens
• Sequence 2: NP_650847.1
• Gene: CG4465 / 42374
• FlyBaseID: FBgn0038750
• Length: 577
• Species: Drosophila melanogaster
• Alignment Length: 548
• Identity: 128/548 - (23%)
• Similarity: 215/548 - (39%)
• Gaps: 120/548 - (21%)

Human     5 DDILEQV-GESGWFQKQAFLI--LCLLSAAFAPICVGIVFLGFTPDHHCQSPGVAELSQRCGWSP 66
            ||::..: |..|.:|.::.||  ||.:.||:...|:    |...||.:                |
  Fly    59 DDVITHIMGNFGPWQLRSLLILFLCKIPAAWFMACI----LFTAPDLY----------------P 103

Human    67 AEELNYTVPGLGPAGEAFLGQCRRY-EVDWNQSALSCVDPLASLATNRSHLPLGPCQDGWVYDTP 130
            .||........||...:.:.....| .|::.:||.:                :..|:. ::|.|.
  Fly   104 EEEYKCDTTAFGPDVNSTVSLDHCYVMVNYGESAYA----------------MRQCRK-FLYTTG 151

Human   131 GSSIVTEFNLVCADSWKLDLFQSCLNAGFLFGSLGVGYFADRFGRKL-----------CLL---- 180
            ..|:..||:|||.    .|.|.:......|||.|..|..|.:..|.|           |||
  Fly   152 FHSLTMEFDLVCL----CDFFVAWSQYWHLFGLLIGGVAATKLMRVLSPRQIYRTGIWCLLMCSL 212

Human   181 ------------GTVLVNAVSGVLMAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSR 233
                        |...:.|||...|..|..|        :.|.::.|.:..| ||
  Fly   213 LMGLVKDFSLHCGLRCLAAVSCCFMITSGQY--------IFGDITAGKYRVG-TL---------- 258

Human   234 RTVAIMYQMAFTVGLVALTGLAYALPHWRWLQLAV--SLPTFLFLLYYWCVPESPRWLLSQKRNT 296
                |:|...:.:||:.|.|||...|.|:.:.|.|  ||...:|||.:  .|:||||.|...:..
  Fly   259 ----ILYDCFWALGLILLPGLASNAPSWQHIYLGVTLSLLVIVFLLPW--TPDSPRWQLQHTKEA 317

Human   297 E-----AIKIMDHIAQKNGKLPPADLKMLSLEEDVTEKL---SPSFADLFRTPRLRKRTFILMYL 353
            :     .:.|:...|:.||::.....::....|::.|::   .|:...:......|:.||.|:.:
  Fly   318 QLAIERTVGILLEAARTNGRMHKVSKELPQQLEELRERMLEPMPAVHWMHLWMGQRRSTFHLVAV 382

Human   354 WF---TDSVLYQGLILHMGATS-GNLYLDFLYSALVEIPGAFIAL-ITIDRVGRIYPMAMS-NLL 412
            ..   |..|:..||:||:.:.. .:|..:.|...|.|:.|.|:|| :|.:...|.:..|.. .::
  Fly   383 HMALATFMVVNTGLLLHVRSFGREHLVSNTLAMGLAEMLGCFLALHLTFNLSERKWQWAGGFAIV 447

Human   413 AGAACLVMIFIS----PDLH--WLNIIIMCVGRMGITIAIQMICLVNAELYPTFVRNLGVMVCSS 471
            .|....:..|::    |:::  .|.:::..:.:..:..|..||.....||.|...|:.......:
  Fly   448 VGCIGSICWFLAEEDMPEVYGLTLGLLMASLPQAAVACAQSMILACLGELVPMEQRSCLSFSAVT 512

Human   472 LCDIGGIITPFIVFRLREVWQALPLILF 499
            ...:..:...|:.. ||:|..||.|..|
  Fly   513 WARVWQLSASFLTL-LRQVSPALSLSAF 539

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A1	XP_005267160.1	2A0119	12..500	CDD:273328	126/540 (23%)
CG4465	NP_650847.1	MFS_SLC22	143..553	CDD:340875	104/428 (24%)