Protein Alignment SLC22A1 and CG6231

DIOPT Version :10

• Sequence 1: XP_005267160.1
• Gene: SLC22A1 / 6580
• HGNCID: 10963
• Length: 573
• Species: Homo sapiens
• Sequence 2: NP_650819.1
• Gene: CG6231 / 42339
• FlyBaseID: FBgn0038720
• Length: 585
• Species: Drosophila melanogaster
• Alignment Length: 617
• Identity: 152/617 - (24%)
• Similarity: 246/617 - (39%)
• Gaps: 119/617 - (19%)

Human     5 DDILEQVGESGWFQKQAFLILCLLSAAFAPICVGIVF-----LGFTPDHHCQSPGVAELSQRCGW 64
            |.||.:.|:   |.:..|:||.|.  .|..|.|.:.:     :.|.|||.|....:
  Fly     4 DQILAKCGD---FNRYQFMILALF--GFINIIVSMHYFTQTVISFVPDHWCYHDKL--------- 54

Human    65 SPAEELNYTVPGLGPAGEAFLG-QCRRYEVDWN-----QSALSCVDPLASLATNRSHLPLGPCQD 123
                 :|.|...:|.....|.. .|.|.: |.|     .|:.:|                    :
  Fly    55 -----VNMTYKEIGEIYAQFENPSCTRLD-DINGHNVTVSSKAC--------------------E 93

Human   124 GWV--YDTPGSSIVTEFNLVCADSWKLDLFQSCLNAGFLFGSLGVGYFADRFGRKLCLLGTVLVN 186
            .|:  ||....|:.||.|.||..::|..:.||....|.:.|:|..|..:|:.||...|:.:....
  Fly    94 KWIYNYDFGYRSMNTELNWVCDSAYKARIGQSLFFIGSVVGTLFYGLLSDKIGRVPALILSNFCG 158

Human   187 AVSGVLMAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSRRTVAIMYQMA----FTVG 247
            ........|:.:..:..|.|.:.||.:..|:...|.::.|:: ..|.||:.:  .||    :.:|
  Fly   159 FAGDFSTIFTKSVATFTLCRFISGLAADTNFYLMYIIVLEYI-RPSMRTLGL--NMAVGLFYCLG 220

Human   248 LVALTGLAYALPHWRWLQLAVSLPTFLFLLYYWCVPESPRWLLSQKRNTEAIKIMDHIAQKNG-K 311
            ||....||..:.||:......|||..|.:|||:.|.||.:||:::.....||..:..:|:.|| :
  Fly   221 LVFTPWLAVLVGHWQIYLACTSLPILLVVLYYFVVQESAQWLVTRNDIDGAIVRLKRVAKFNGCR 285

Human   312 LPPADLKMLSLEEDVT-------EKLSPSFADLFRTPRLRKRTFILMYLWFTDSVLYQGLILHMG 369
            :..||.........:|       :|...:..|:|||||:||.|.||.:.....::.|..:..::.
  Fly   286 VSQADFDEFRRHCQMTHEMLGGDDKKQATLLDMFRTPRMRKNTLILFFKSMVITLCYDAVSRNVE 350

Human   370 ATSGNLYLDFLYSALVEIPGAFIALITIDRVGRIYPMAMSNLLAGA--ACLVMIFISPDLHWLN- 431
            ....:.::.|..|||..:|.:.:.::..||:|| ..||..:||.|.  .....|.|:...|..|
  Fly   351 GMGISPFIMFSLSALAVLPSSVLLVLLQDRIGR-KGMASGSLLVGGLFTAAAGIAIAYQQHNHNA 414

Human   432 IIIMCV---GRMGITIAIQMICLVNAELYPTFVRNLGVMVCSSLCDIGGIITPFIVFRLREVWQA 493
            |::.|:   .|.|:.|:.:.......||.||.||..||............:.|:|:: |...::|
  Fly   415 ILLACLTIAARFGVAISYESGSQYATELIPTCVRGQGVAAVHVAGFAASFLAPYILW-LGTFFKA 478

Human   494 LPLILFG-------------QRTSKTLLTHLIEDNSCW-----LFAEPAMPGHSGVGPACRGSDA 540
            .|.|:.|             ..|....|...||:...:     :|..|.:  |:
  Fly   479 APSIILGVLFFAGSFVCLLLPETLNRSLPTTIEEGEVFGKGERMFDFPCL--HN----------- 530

Human   541 TSSRDQGGRFARDHEGRREPWEKSKAQRKHDL 572
                        .|:......|..|.:|||.|
  Fly   531 ------------KHDDEESESELEKYKRKHSL 550

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A1	XP_005267160.1	2A0119	12..500	CDD:273328	134/518 (26%)
CG6231	NP_650819.1	2A0119	11..509	CDD:273328	137/542 (25%)