Protein Alignment SLC22A1 and CG16727

DIOPT Version :10

• Sequence 1: XP_005267160.1
• Gene: SLC22A1 / 6580
• HGNCID: 10963
• Length: 573
• Species: Homo sapiens
• Sequence 2: NP_650818.1
• Gene: CG16727 / 42338
• FlyBaseID: FBgn0038719
• Length: 545
• Species: Drosophila melanogaster
• Alignment Length: 542
• Identity: 138/542 - (25%)
• Similarity: 224/542 - (41%)
• Gaps: 112/542 - (20%)

Human     5 DDILEQVGESGWFQKQAFLILCLLSAAFAPICVGI-----VFLGFTPDHHCQSP-----GVAELS 59
            |.:||:.|..|.||   |:||.|.  .:..|...:     ..:.|||:|.|...     |.|||
  Fly     4 DRVLEKCGNFGRFQ---FVILILY--GYTNILSSLHYFSQTLITFTPEHWCSHDDLMGLGAAEL- 62

Human    60 QRCGWSPAEE-----LNYTVPGLGPAGEAFLGQCRRYEVDWNQSALSCVDPLASLATNRSHLPLG 119
             |..:|....     |:..:.|.|.|.|.
  Fly    63 -RSIYSNVSHPSCTLLSEVINGTGVASEE------------------------------------ 90

Human   120 PCQDGWVYDTPG--SSIVTEFNLVCADSWKLDLFQSCLNAGFLFGSLGVGYFADRFGRKLCLLGT 182
            .||| |:::...  .|:.||...||..|.:..:.||....|.:.|::..|:.:|..||    |..
  Fly    91 SCQD-WIFERENGYESLTTELKWVCDKSHQPAVGQSFFFLGSVVGTISFGFLSDHIGR----LPA 150

Human   183 VLVNAVSGVLMAFSPNYMSML----LFRLLQGLVSKGNWMAGYTLITEFVGSGSRRT--VAIMYQ 241
            :|:.|:||....|..:::..|    ..|.:.||.:...:...|.|:.|:: |..|||  :.|:..
  Fly   151 MLMAALSGATGDFITSFVHTLPWFAFSRFVSGLSTDTMYYLMYILVFEYL-SPKRRTFGLNIILA 214

Human   242 MAFTVGLVALTGLAYALPHWR---WLQLAVSLPTFLFLLYYWCVPESPRWLLSQKRNTEAIKIMD 303
            :.:..||:....:|..:.:||   ||   .|||....|:|...:.||.:|||::|:..||:..:.
  Fly   215 VFYCFGLMTSPWIAMWIGNWRRYLWL---ASLPALGVLIYPLLICESAQWLLTKKKYDEAVACLK 276

Human   304 HIAQKNGKLPPADL----------KMLSLEEDVTEKLSPSFADLFRTPRLRKRTFILMYLWFTDS 358
            .:|:.||:.....:          ||  .||....|...:|..:|:|||||:.|..|:......:
  Fly   277 KVAKFNGRQVEDSVFDEFVKHYREKM--NEESKLNKQMDTFLGMFKTPRLRRFTTTLLVKSVIIT 339

Human   359 VLYQGLILHMGATSGNLYLDFLYSALVEIPGAFIALITIDRVGRIYPMAMSNLLAGAAC-----L 418
            :.|..:..:|.....:.:..|..::.|.:|..|..|:..:::|| ..||...||.||..     .
  Fly   340 LSYDVINRNMEGLGSSPFKLFSLTSSVYLPAGFTILLLQNKIGR-KGMACGALLVGAIITAVTGF 403

Human   419 VMIFISPDLHWLNIIIMC-VGRMGITIAIQMICLVNAELYPTFVRNLGV-------MVCSSLCDI 475
            ::..:.|..:.:.:.:|. :||.|.|::........||:.||.||...|       :..|||.
  Fly   404 LIAVLDPSENAVLLALMVGLGRFGTTVSYDAEIQYAAEIIPTSVRGQAVSNIHVVGLASSSLA-- 466

Human   476 GGIITPFIVFRLREVWQALPLI 497
                  |.|..|.:.::.||.|
  Fly   467 ------FYVIYLAQYYKPLPSI 482

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A1	XP_005267160.1	2A0119	12..500	CDD:273328	135/535 (25%)
CG16727	NP_650818.1	2A0119	11..509	CDD:273328	135/535 (25%)