Protein Alignment SLC22A1 and CG17751

DIOPT Version :10

• Sequence 1: XP_005267160.1
• Gene: SLC22A1 / 6580
• HGNCID: 10963
• Length: 573
• Species: Homo sapiens
• Sequence 2: NP_650816.3
• Gene: CG17751 / 42336
• FlyBaseID: FBgn0038717
• Length: 533
• Species: Drosophila melanogaster
• Alignment Length: 602
• Identity: 140/602 - (23%)
• Similarity: 233/602 - (38%)
• Gaps: 120/602 - (19%)

Human     4 VDDILEQVGESGWFQKQAFLILCLLSAAFAPICVGI-----VFLGFTPDHHCQSPGVAELSQRCG 63
            :..:||:.|..|.:|     ||.|....:..|...:     ..:.|||.|.|..|
  Fly     3 LQSVLEKCGNFGPYQ-----ILLLGLFGYTNIVSSLHYFSQTIISFTPSHRCSRP---------- 52

Human    64 WSPAEELNYTVPGLGPAGEAFLGQCRRYEVDWNQSALSCVDPLASLATNRSHLPLGPCQDGWVYD 128
                |:..       |...:.| .|...:.|   ....|.                    .|.::
  Fly    53 ----EDYQ-------PNSTSLL-SCSVMQFD---KEFKCT--------------------SWDFE 82

Human   129 TPGS--SIVTEFNLVCADSWKLDLFQSCLNAGFLFGSLGVGYFADRFGR-KLCLLGTVLVNAVSG 190
            ...:  ||.||...||.|::||.:.||....|...||:..||.|||.|| ..|:|.| |..|...
  Fly    83 RESNYESITTELEWVCDDAYKLAVGQSFFFIGSALGSIFFGYLADRIGRLPACVLST-LTGASGD 146

Human   191 VLMAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSRRT--VAIMYQMAFTVGLVALTG 253
            ...:|..:.......|.:.||.....::..|.|:.|:: |...||  :.|:..:.:.|||:....
  Fly   147 FFTSFVGSLPWFSFTRFISGLFMDTQYVLMYILVFEYL-SPQHRTFGLNIILGVFYCVGLMISPW 210

Human   254 LAYALPHWRWLQLAVSLPTFLFLLYYWCVPESPRWLLSQKRNTEAIKIMDHIAQKNGKLPPADLK 318
            :|..:.:||....|.|||....||:...:.||..|||::.:..:|.|.:..:|:.||:
  Fly   211 IAIWVTNWRNYLWAASLPALGMLLFPVFLHESAEWLLTKGKFEKAEKSLRGVAKFNGR------- 268

Human   319 MLSLEEDV--------TEKL-------SPSFADLFRTPRLRKRTFILMYLWFTDSVLYQGLILHM 368
              .:::.|        .|||       |.:|..:.|||||||.|.||:......::.:..|..::
  Fly   269 --QVDDSVFDEFIKHYREKLNNSQNKSSDTFMGMLRTPRLRKFTIILLIKSMIITIAFDILSRNV 331

Human   369 GATSGNLYLDFLYSALVEIPGAFIALITIDRVGRIYPMAMSNLLAGA------ACLVMIFISPDL 427
            .....:.:..|.||....:|.....::..:::|| ..||.::|..||      ..||......|.
  Fly   332 EGVGISPFKLFSYSGFCYLPAGLTIILFQNKIGR-KGMACASLFVGAIITAATGYLVATLDPSDY 395

Human   428 HWLNIIIMCVGRMGITIAIQMICLVNAELYPTFVRNLGVMVCSSLCDIGGIITPFIVFRLREVWQ 492
            ..|...::.:||.|..:|........||:.||.|:..||.....:.:.....:.:|:: |...::
  Fly   396 SVLLGFMVSLGRYGAVVAYDAEAQYAAEIIPTSVKGRGVANIHVVGNAFAFFSSYIIY-LGTFYK 459

Human   493 ALPLILFGQRTSKTLLTHLIEDNSCWLFAEPAMPGHSGVGPACRGSDATSSRDQGGRFARDHE-- 555
            .||.:         :::.::...:|...|.|... |..:         ..:.::|..||:..:
  Fly   460 PLPSL---------MISFILLIGACLCLALPETL-HKNL---------PQNLEEGEMFAKGEKWY 505

Human   556 -----GRREPWEKSKAQ 567
                 .||...:||..|
  Fly   506 FFPCFSRRPKTQKSATQ 522

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A1	XP_005267160.1	2A0119	12..500	CDD:273328	126/518 (24%)
CG17751	NP_650816.3	2A0119	11..490	CDD:273328	130/560 (23%)