Protein Alignment SLC22A1 and CG7342

DIOPT Version :10

• Sequence 1: XP_005267160.1
• Gene: SLC22A1 / 6580
• HGNCID: 10963
• Length: 573
• Species: Homo sapiens
• Sequence 2: NP_650815.2
• Gene: CG7342 / 42335
• FlyBaseID: FBgn0038716
• Length: 540
• Species: Drosophila melanogaster
• Alignment Length: 561
• Identity: 148/561 - (26%)
• Similarity: 233/561 - (41%)
• Gaps: 98/561 - (17%)

Human     1 MPTVDDILEQVGESGWFQKQAFLILCLLSAAFAPICVGIVFLGFTPDHHCQSPGVAELSQRCGWS 65
            |..||.|||:.|:....|....|:.|:::...|........:.|.|.:.|.....|.:.     |
  Fly     1 MLEVDKILEKCGDFSRLQMIMLLLFCVINVLSALHYYSQTIISFVPKYWCADGLPASIE-----S 60

Human    66 PAEELNYTVPGLGPAGEAFLGQCRRYEVDWNQSALSCVDPLASLATNRSHLPLGPCQD------- 123
            |.:.                               ||: ||     ||:......|..
  Fly    61 PVDS-------------------------------SCL-PL-----NRNISTPNTCYSYNYELYM 88

Human   124 GWVYDTPGSSIVTEFNLVCADSWKLDLFQSCLNAGFLFGSLGVGYFADRFGRKLCLLGTVLVNAV 188
            |:      .|..:|.:.||||:|||.|.||....|.:.||:.:||.||..||...|:...|:...
  Fly    89 GY------QSFPSEMDWVCADAWKLTLGQSMFFVGSVVGSMVLGYLADVVGRLPILIVANLIAMT 147

Human   189 SGVLMAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSRRTVAIMYQMAF--TVGLVAL 251
            ..:|..:|.|.....:||::.|:.:..|::..|.|:.|:: ..|.||:.:...:.|  .:|.:|.
  Fly   148 GNLLTIWSTNVTLFCMFRMISGIATDSNFVMMYILVMEYM-RPSVRTLGLSICIGFFYCLGSMAA 211

Human   252 TGLAYALPHWRWLQLAVSLPTFLFLLYYWCVPESPRWLLSQKRNTEAIKIMDHIAQKNGKLPPAD 316
            ..:|..:..||...|..|||..:...:|..||||.:||:|:::...|:..:..:|:.||:.....
  Fly   212 PWIAVLMRSWRGFLLTTSLPLLVVPFFYLIVPESIQWLISKQKYDSAVVCLKRVAKINGRHVEES 276

Human   317 LKMLSLEE----DVTEKLSPSFADLFRTPRLRKRTFILMYLWFTDSVLYQGLILHMGATSGNLYL 377
            .....:||    ...:|.||...|||:|||||:.|.||.:.....::.|..:..::.....:.::
  Fly   277 AYAEFIEECKCSQQNQKASPHLLDLFQTPRLRRHTLILFFKSMVITLCYDAVSRNVQGLGISPFV 341

Human   378 DFLYSALVEIPGAFIALITIDRVGRIYPMAMSNLLAGAACLV---MIF---ISPDLHWLNIIIMC 436
            .|..||...:|...:.:...||:||....:.|.||:|....|   :||   .|.....|.:.:..
  Fly   342 MFSLSATAILPACLLIIALQDRIGRKAMASASLLLSGIFISVTGGIIFAASASDKTTTLLVSLSV 406

Human   437 VGRMGITIAIQMICLVNAELYPTFVRNLGVMVCSSLCDIGG----IITPFIVFRLREVWQALPLI 497
            |||.|:|:|.........||.||.||..||    :...:.|    ..:.:|:| .|.|:..||.|
  Fly   407 VGRFGVTVAYNSGAQYATELIPTCVRGQGV----AAVHVAGYAFTFFSAYILF-TRSVFSPLPEI 466

Human   498 LFG--------------QRTSKTLLTHLIED------NSCW 518
            :.|              :...:||.|.| ||      |..|
  Fly   467 ILGVLSLLGACLCLLLPETLHRTLPTSL-EDGENFGKNDRW 506

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A1	XP_005267160.1	2A0119	12..500	CDD:273328	133/510 (26%)
CG7342	NP_650815.2	2A0119	12..491	CDD:273328	135/532 (25%)