Protein Alignment SLC22A1 and CG12783

DIOPT Version :10

• Sequence 1: XP_005267160.1
• Gene: SLC22A1 / 6580
• HGNCID: 10963
• Length: 573
• Species: Homo sapiens
• Sequence 2: NP_001262644.2
• Gene: CG12783 / 42019
• FlyBaseID: FBgn0038448
• Length: 493
• Species: Drosophila melanogaster
• Alignment Length: 476
• Identity: 100/476 - (21%)
• Similarity: 173/476 - (36%)
• Gaps: 118/476 - (24%)

Human   106 LASLATNRSHL----PLGPCQDGWVYDTPGSSIVTEFNLVCADSWKLDLFQSCLNAGFLFGSLGV 166
            :..:...|.||    .||..|...:.:|.|..|:.. ..||..........|...|||    :|:
  Fly     8 MEDIGFGRVHLFATVTLGLLQMLTIQETMGMGIIGP-AAVCDLRMNEAQLASLTAAGF----MGI 67

Human   167 -------GYFADRFGRKLCLLGTVLVNAVSGVLMAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLI 224
                   ||..|:.||:..||.|:.::.:..:...|:..:....:.|.:..:...|......|.:
  Fly    68 ICSSYFWGYITDKKGRRWTLLRTITISNLCSLASMFTVTFTGFFVMRFITCIFVAGPSFVAATYL 132

Human   225 TEFVGSGSRRTV--AIMYQMAFTVGLVALTGLAYA--------------------LPHWRWLQLA 267
            :||.   |.|.:  :|.:...|| |...::..|:|                    |..||.|...
  Fly   133 SEFC---SHRIMVRSITHLYMFT-GFAMISCPAWATLFLSSGLIEFEEKLVGSLTLRPWRVLGCL 193

Human   268 VSLPTFLFLLYYWCVPESPRWLLSQKRNTEAIKIMDHIAQKN-GKLPPAD--LKMLSLEEDVTEK 329
            ..||..:..|....:||||::||........:..|:.|::|| |:....|  .::|:.:|.|..|
  Fly   194 YILPGVVAFLLLLLLPESPKFLLMIGETKRGLDTMEWISRKNTGRTLSEDQMKRLLAYQEHVQVK 258

Human   330 LSPSFADLFRT------PRLRKR-----------TFIL------MYLWFTDSVLYQGLILHMGAT 371
            ......:.||:      |.:||.           .|:|      :.:|:|  .:.....:..|.|
  Fly   259 RRKEHQNFFRSMLDDAMPLVRKPYGGYFTCVCMVMFVLGLLTHGLGIWYT--AMRNRCNMRQGNT 321

Human   372 SGNLYLDFLYSALVEIPGAFIA------LITIDR---------VGRIYPMAMSNLLAGAACL--- 418
            :|..:...|:   |...|.||.      ::..|.         :|.:|.:..:...|...|:
  Fly   322 NGMTFCQVLF---VPETGPFIETESDLDVVCSDSFKGFNDSFVLGFVYVVLYNISWASLFCVHKK 383

Human   419 ---------------VMIFISPDLHWLNIIIMCVGRMGITIAI---QMICLVNAELYPTFVRNLG 465
                           ::||.:..:..|..::..:...||.|.:   .::..|     ||::|  |
  Fly   384 VMFVFSLVASSTFGFLLIFATNHMLQLFSLVFLIAFPGIIIGLLGGSLLVFV-----PTYLR--G 441

Human   466 VMVCSSL--CDIGGIITPFIV 484
            ..:|.||  |..|......:|
  Fly   442 KALCISLMWCRCGAAFGAMLV 462

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A1	XP_005267160.1	2A0119	12..500	CDD:273328	100/476 (21%)
CG12783	NP_001262644.2	synapt_SV2	<2..>310	CDD:130366	70/312 (22%)