Protein Alignment SLC22A1 and CG6126

DIOPT Version :10

• Sequence 1: XP_005267160.1
• Gene: SLC22A1 / 6580
• HGNCID: 10963
• Length: 573
• Species: Homo sapiens
• Sequence 2: NP_650528.1
• Gene: CG6126 / 41967
• FlyBaseID: FBgn0038407
• Length: 555
• Species: Drosophila melanogaster
• Alignment Length: 587
• Identity: 166/587 - (28%)
• Similarity: 248/587 - (42%)
• Gaps: 82/587 - (13%)

Human     4 VDDILEQVGESGWFQKQAFLILCLLSAAFAPICVGIVFLGFTPDHHCQSPGVAELSQRCGWSPAE 68
            ::|::.::||.|.:|...|.:..|.........:.:|.:...|:|.|...||...|
  Fly     7 LEDLMGKLGEFGKYQFLQFFLQVLSGLTAGMHMLSLVTVAAVPEHRCFIEGVDNSS--------- 62

Human    69 ELNYTVPGLGPAGEAFLGQCRRYEVDWNQSALSCVDPLASLATNRSHLPLGPCQDG--------- 124
             |:.|                    .||.||:....||.......|.|...|...|
  Fly    63 -LSVT--------------------PWNSSAILAAIPLKPNGELESCLMFDPSSPGTNTTINCER 106

Human   125 WVYDTP--GSSIVTEFNLVCADSWKLDLFQSCLNAGFLFGSLGVGYFADRFGRKLCLLGTVLVNA 187
            :||||.  .:|...::|.||...|...:.|:....|...|::.:|..||:.|||.....:.|...
  Fly   107 YVYDTTYYKTSRTIDWNFVCDRRWMGAIVQTVFMLGVFTGAVTLGGLADKVGRKTVFCWSALFQL 171

Human   188 VSGVLMAFSPNYMSMLLFRLLQGLV-SKGNWMAGYTLITEFVGSGSRRTVAIMYQMAFTVGLVAL 251
            :.||.:||.|.|.|.::.|.|.|:| |.|.::.|:.|..|.||...|....|.:|..|..|::.:
  Fly   172 IIGVGVAFIPEYFSFMVARYLLGIVGSAGAYICGFVLTMELVGPTKRTVCGITFQAVFAGGIMLV 236

Human   252 TGLAYALPHWRWLQLAVSLPTFLFLLYYWCVPESPRWLLSQKRNTEAIKIMDHIAQKNGKLPPAD 316
            .|....:|..:|||:...|...|||.::|.:.||||||..|.|..||:.|:....:.||...|.|
  Fly   237 AGWGALIPDRQWLQVIYGLHGCLFLGHWWWLDESPRWLWMQGRAAEAVDIVAKGLRINGSGIPVD 301

Human   317 ----LKMLSLEEDVTEKLSPSFADLFRTPRLRKRTFILMYLWFTDSVLYQGLILHMGATSGNLYL 377
                ::....:....||.|...:||||||.||.:|..:...||.:|::|.||.|..|...||.||
  Fly   302 KEYYVQKAKQQAAAEEKSSAGLSDLFRTPNLRMKTLNVCLCWFANSLVYYGLSLSAGKLYGNPYL 366

Human   378 DFLYSALVEIPGAFIALITIDRVGRIYPMAMSNLLAGAACLVMIFISPDLHWLNIIIMCVGRMGI 442
            ......|||.|.....:..:||:||....:...|..|..|:|..:|:........::| .|::.|
  Fly   367 ILFIMGLVEFPSYITIVFVLDRLGRRSITSTLMLGGGLCCIVAAYIAQGSTTSTAVVM-AGKLLI 430

Human   443 TIAIQMICLVNAELYPTFVRNLGVMVCSSLCDIGGIITPFIVFRLREVWQALPLILFGQRTSKTL 507
            ..:..:|...:|||:||.|||..:.:.|....:.|.:||.|.. |......:|.:|||
  Fly   431 AGSFAVIYNYSAELFPTVVRNSAMGLGSMCARLSGALTPLITL-LDSFDPKIPAVLFG------- 487

Human   508 LTHLIEDNSCWLFAEP-----AMPGHSGVGPACRGSDATSSRDQGGRFARDHEGRREPWEKSKAQ 567
            :..||  :..|:...|     .||               .|.:.|..|     |:.:.|....|.
  Fly   488 VVALI--SGFWVMFLPETMNQPMP---------------ESIEDGENF-----GKGDTWFSQCAG 530

Human   568 RK 569
            ||
  Fly   531 RK 532

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A1	XP_005267160.1	2A0119	12..500	CDD:273328	149/503 (30%)
CG6126	NP_650528.1	2A0119	15..510	CDD:273328	157/550 (29%)