Protein Alignment SLC22A1 and CG8925

DIOPT Version :10

• Sequence 1: XP_005267160.1
• Gene: SLC22A1 / 6580
• HGNCID: 10963
• Length: 573
• Species: Homo sapiens
• Sequence 2: NP_650526.1
• Gene: CG8925 / 41963
• FlyBaseID: FBgn0038404
• Length: 670
• Species: Drosophila melanogaster
• Alignment Length: 529
• Identity: 145/529 - (27%)
• Similarity: 225/529 - (42%)
• Gaps: 94/529 - (17%)

Human    26 CLLSAAFAPICVGIVFL---GFTP-DHHCQSPGVAELSQRCGWSPAEELNYTVPGLGPAGEAFLG 86
            |.|.:.|..||...:|:   ...| |..|..|  ..|.|   .|.:|..|.:....|
  Fly   165 CALLSIFQAICTFHIFVYVFQIAPKDFWCARP--ENLMQ---MSVSEWRNISQSSNG-------- 216

Human    87 QCRRYEVDWNQSALSCVDPLASLATNRSHLPLGPCQDGWVY---DTPGS--SIVTEFNLVCADSW 146
             |...:||:.|.... .:.|.:...|.:.|....|   |.:   |..||  ::|.||:|||...
  Fly   217 -CLLLDVDYTQVTYE-NNQLINWPENATDLGYRQC---WHFEFSDVDGSAKTLVQEFDLVCGRD- 275

Human   147 KLDLFQSCLNAGFLFGSLGVGYFADRFGRKLCLLGTVLVNAVSGVLMAFSPNYMSMLLFRLLQGL 211
            .|.|.::|...|...|::..|:.:|||||:..|:..|.:.:|.|.::|||.:....:..|::.|.
  Fly   276 ILSLVETCFLVGAAAGAVLSGWISDRFGRRHTLMAFVTIQSVFGGILAFSTSVAMFMSLRVIIGF 340

Human   212 VSKGNWMAGYTLITEFVGSGSRRTVAIMYQMAFTVGLVALTGLAYALPHWRWLQLAVSLPTFLFL 276
            .|....:..:.|:.|.|....|..:.|:..:...:..|...||||.:..||.||||:|.|..:.|
  Fly   341 ASMTVTVVSFVLVVELVSGKWRTVIGILNILPVAISYVLSAGLAYLIRDWRHLQLAISWPWLIML 405

Human   277 LYYWCVPESPRWLLSQKRNTEAIKIMDHIAQKNG---KLPPADLKML----------------SL 322
            ..::.:||||||||:|.|..|...:::..|:.||   .||....|.|                |:
  Fly   406 SIWFWLPESPRWLLAQGRLDELCGLIERAARMNGTSASLPSNYRKTLEAAVPRAVQSPPEATTSV 470

Human   323 EEDVTEKLSPS--------------FADLFRTPRLRKRTFILMYLWFTDSVLYQGLILHMGATSG 373
            |....|..:|.              .|..:||      |.:.:.:|.|..::|.||.||:....|
  Fly   471 ESKAVEADAPDPSASGHVNPLLVVFSAKYWRT------TCLTLVIWLTLIIIYFGLTLHLSNLGG 529

Human   374 NLYLDFLYSALVEIPGAFIALITIDRVGRIYPMAMSNLLAGAACLVMIFISPDLHWLNIIIMCVG 438
            |:|::...:..||.....|:::.:.:||....:....||.|..||....:|             .
  Fly   530 NIYINSAVAGTVEAISICISILVVLKVGIRRSLIGYMLLPGLCCLATNLVS-------------N 581

Human   439 RMGITIAIQMI--CLVNAE----------LYPTFVRNLGVMVCSSLCDIGGIITPFIVFRLREVW 491
            :.|: ||:..|  ||:.|.          .|||.|||.||.:.:....|..|:.||: ::|..:.
  Fly   582 QTGV-IALATIAKCLIGANNAIIPTYTAMQYPTIVRNFGVGMGNLASGIALILVPFL-WKLEHID 644

Human   492 QALPLILFG 500
            ..|||.:.|
  Fly   645 PLLPLNVMG 653

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A1	XP_005267160.1	2A0119	12..500	CDD:273328	144/527 (27%)
CG8925	NP_650526.1	MFS_SLC22	249..666	CDD:340875	122/430 (28%)