Protein Alignment SLC22A1 and CG14856

DIOPT Version :10

• Sequence 1: XP_005267160.1
• Gene: SLC22A1 / 6580
• HGNCID: 10963
• Length: 573
• Species: Homo sapiens
• Sequence 2: NP_650391.1
• Gene: CG14856 / 41790
• FlyBaseID: FBgn0038261
• Length: 557
• Species: Drosophila melanogaster
• Alignment Length: 559
• Identity: 133/559 - (23%)
• Similarity: 227/559 - (40%)
• Gaps: 104/559 - (18%)

Human     5 DDILEQVGESGWFQKQAFLILCLLSAAFAPICVGIV--------FLGFTPDHHCQSPGVAELSQR 61
            |:||.:.|:|..:|   :::|.|..     :.:.||        .:||.|||.|..   .:|..|
  Fly     6 DEILVKCGDSHRYQ---YMLLALYG-----LLMFIVSRHYFAQNVIGFVPDHWCYH---EQLENR 59

Human    62 CGWSPAEELNYTVPGLGPAGEAFLGQCRRYEVDWNQSALSCVDPLASLATNRSHLPLGPCQDGWV 126
               |.||......|...|:       |.|         |:.::...|.||..|.    || :.|:
  Fly    60 ---SYAEIAAIYAPFKRPS-------CTR---------LASINMDGSNATASSE----PC-NRWI 100

Human   127 --YDTPGSSIVTEFNLVCADSWKLDLFQSCLNAGFLFGSLGVGYFADRFGRKLCLLGTVLVNAVS 189
              ||....|:..:.|.||.|::|..:.||....|.:.|:|..|...||.||   :...||.|. .
  Fly   101 YHYDHGFISMNADLNWVCDDAYKARVGQSLFFVGSMCGTLLFGLLGDRIGR---IKAVVLANC-C 161

Human   190 GVL----MAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSRRTVAIMYQMA--FTVGL 248
            |.|    ..|:...::....|.:.||.::.|....:.|:.|:| |.:.|:|.:...|.  :.:|:
  Fly   162 GFLGDSATIFAETLLTFSASRFVSGLAAEANSYLMFILVLEYV-SPTMRSVGLNLTMCVFYGLGM 225

Human   249 VALTGLAYALPHWRWLQLAVSLPTFLFLLYYWCVPESPRWLLSQKRNTEAIKIMDHIAQKNGK-L 312
            :..:.....|..||...:..:||..|...:|:.:.||.:||::::....|...:..:|:.|.: :
  Fly   226 ICASWQGVWLGSWRSFMVWTALPQLLVTGFYFLIQESAQWLVTRQDFDGAELRLRRVAKFNRRDV 290

Human   313 PPADLKML-----SLEEDVTEKLS----PSFADLFRTPRLRKRTFILMYLWFTDSVLYQGLILHM 368
            ..||.::.     :.|.:...::|    ....|.|:.||||.|...:..::...::.|..:..::
  Fly   291 SEADYELFRQHCKTKESEARSQMSMQKQARLIDSFKLPRLRLRLIYVTVVFSIVTLCYNTMSRNV 355

Human   369 GATSGNLYLDFLYSALVEIPGAFIALITIDRVGR----IYPMAMSNLLAGAACLVMIFISPDLHW 429
            ...|.:.::.|...||...|............||    :..|..:.|:.....:::.|      |
  Fly   356 EGLSISPFVMFSLFALTLPPSGIFQTQVQKHFGRKFTSVVSMTATGLMTATTGILLAF------W 414

Human   430 LN--------IIIMCVGRMGITIAIQMICLVNAELYPTFVRNLGVMVCSSLCDIGGIITPFIV-- 484
            ..        :::||  |.||::.......::.||.||.||:.|:.|..........|:|||:
  Fly   415 TQHSATVMVCLLLMC--RFGISVTTGSTMQISTELMPTCVRSSGLAVIHVTAAALSFISPFILHL 477

Human   485 ---FR-----------LREVWQALPLILFGQRTSKTLLT 509
               ||           |...|  :.|:|...|..|..||
  Fly   478 DTYFRAASSIITCILLLVSAW--ICLLLSETRNKKLPLT 514

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A1	XP_005267160.1	2A0119	12..500	CDD:273328	126/541 (23%)
CG14856	NP_650391.1	2A0119	13..514	CDD:273328	128/550 (23%)