Protein Alignment SLC22A1 and CG14855

DIOPT Version :10

• Sequence 1: XP_005267160.1
• Gene: SLC22A1 / 6580
• HGNCID: 10963
• Length: 573
• Species: Homo sapiens
• Sequence 2: NP_650390.2
• Gene: CG14855 / 41789
• FlyBaseID: FBgn0038260
• Length: 556
• Species: Drosophila melanogaster
• Alignment Length: 600
• Identity: 150/600 - (25%)
• Similarity: 247/600 - (41%)
• Gaps: 115/600 - (19%)

Human     5 DDILEQVGESGWFQKQAFLILCLLSAAFAPICVGIVF-----LGFTPDHHC-----QSPGVAELS 59
            ::||.:.|.|..:|   |::|.|.  .:..:.|.:.:     :.|.|||.|     ::...||:.
  Fly     4 EEILAKCGNSSRYQ---FVLLALY--GYLMVVVSMHYFSQNVISFVPDHWCYHEQLENRSFAEIE 63

Human    60 QRCGWSPAEELNYTVPGLGPAGEAFLGQCRRYEVDWNQSALS---CVDPLASLATNRSHLPLGPC 121
            :.  :|..|:.:.|             :..:.:.|.....||   |         ||
  Fly    64 KI--YSQFEKPSCT-------------RLEKIDEDGQNHTLSRERC---------NR-------- 96

Human   122 QDGWV--YDTPGSSIVTEFNLVCADSWKLDLFQSCLNAGFLFGSLGVGYFADRFGRKLCLLGTVL 184
               |:  ||....|:.||.|.||.:::|..:.||....|.:.|:|..|...||.||   :...:|
  Fly    97 ---WIYKYDFGYKSMNTELNWVCDEAYKARVGQSLFFVGSVCGTLAFGLLGDRIGR---IRALIL 155

Human   185 VNAVSGVLMAFSPNYMSML----LFRLLQGLVSKGNWMAGYTLITEFVGSGSRRTVAIMYQMA-- 243
            .| ..|.|..||..:...|    :.|.:.||.:..|....|.||.|:| |.|.|.|.:...:.
  Fly   156 AN-WCGFLGDFSTIFAGSLTSFSISRFISGLAADANSYLMYILILEYV-SPSLRNVGLNTVLGSF 218

Human   244 FTVGLVALTGLAYALPHWRWLQLAVSLPTFLFLLYYWCVPESPRWLLSQKRNTEAIKIMDHIAQK 308
            :.:||:....||..:.|||......|:|..|..|:|:.|.||.:||:::.....||:.::.:|:.
  Fly   219 YCLGLIGACWLAVWVGHWRIFLACSSVPLLLVTLFYFLVQESAQWLVTRNDVDGAIRRLERVAKI 283

Human   309 NGK-LPPADLKMLSL------EEDVTEKLSPSFADLFRTPRLRKRTFILMYLWFTDSVLYQGLIL 366
            |.: :...|.|...:      .:|..::......|:.:|||:|...|.|:.::......|..:..
  Fly   284 NRRQVADKDFKDFRIYCEQHYRKDKNQEEHAKLLDMLKTPRMRSTAFKLLLIFIIIVPCYNTIAR 348

Human   367 HMGATSGNLYLDFLYSALVEIPGAFIALITIDRVGR----IYPMAMSNLLAGAACLVMIFISPDL 427
            ::.....:.::.|..:||...|..::..:..||:||    :..||::.:.|.||.||   ||...
  Fly   349 NVEGLGISPFIMFSLNALTLPPSGYLQGLLQDRMGRKATAVGWMAITGIFAVAAGLV---ISQGS 410

Human   428 HWLNIIIMCVG-----RMGITIAIQMICLVNAELYPTFVRNLGVMVCSSLCDIGGIITPFIVFRL 487
            : .|:::: ||     |.|::||.......:.||.||.||..||.|..........::|:|: .|
  Fly   411 N-RNVLLL-VGLTMAARFGVSIADGASSQFSTELIPTSVRGRGVAVVHVAGFAASFLSPYIL-HL 472

Human   488 REVWQALPLILFGQRTSKTLLTHLIEDNSCWLFAEPAMPGHSGVGPACRGSDATSSRDQGGRFAR 552
            ...::..|.|:.|       |..|.....|.|.            |..|......|..:|..|.|
  Fly   473 GTYYKPAPSIILG-------LLFLSGAYVCLLL------------PETRNKKLPMSLAEGEEFGR 518

Human   553 D--------HEGRRE 559
            .        |..|||
  Fly   519 GEGIFDFLRHMFRRE 533

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A1	XP_005267160.1	2A0119	12..500	CDD:273328	133/524 (25%)
CG14855	NP_650390.2	2A0119	11..507	CDD:273328	140/565 (25%)