Protein Alignment SLC22A1 and CG14691

DIOPT Version :10

• Sequence 1: XP_005267160.1
• Gene: SLC22A1 / 6580
• HGNCID: 10963
• Length: 573
• Species: Homo sapiens
• Sequence 2: NP_650012.2
• Gene: CG14691 / 41287
• FlyBaseID: FBgn0037829
• Length: 522
• Species: Drosophila melanogaster
• Alignment Length: 471
• Identity: 87/471 - (18%)
• Similarity: 170/471 - (36%)
• Gaps: 117/471 - (24%)

Human   120 PCQDGWVYDTPGSSIV-----TEFNLVCADSWKLDLFQSCLNAGFLFGSLGVGYFADRFGRKLCL 179
            ||....|:.....|.|     .:.:|...|.   .:..:...||.:..::..|:.||..||:..|
  Fly    37 PCLTAMVFSASALSYVMPSAECDLDLSIVDK---GMLHAVTYAGMIISAVPWGFIADTIGRRPVL 98

Human   180 LGTVLVNAVSGVLMAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSRRTVAIMYQMAF 244
            :....::....:..:.|.|...::.|:...||:..|.:....:.:.||.|...|..:.:...:..
  Fly    99 ISGGWLDGFFVLCASLSQNTAQLMAFKFFDGLIICGPFAVVVSYLAEFHGKKHRPYIMLFVGLCV 163

Human   245 TVGLVALTGLAYAL--------------PHWRWLQLAVSLPTFLFLLYYWCVPESPRWLLSQKRN 295
            ::|.:.|..|:|.|              ..|:......|.|:.|....:..:||||::|:||...
  Fly   164 SIGSMILPLLSYLLLPVPILFTVSSMKFRTWQVFLAVSSAPSLLSGFLHIFLPESPKFLMSQGNY 228

Human   296 TEAIKIMDHIAQKNGK-----------LPPA-----DLKMLSLEEDVTEKLS---PSFADLFRTP 341
            .:|:..:..|.:.|.:           ..|.     ||........:.|:.|   ..|.|.|:.
  Fly   229 KKALDSLQRIYKLNKRKSRESYPIKHLTDPTPDRSDDLDGTGRPSTLQERFSRAQSKFIDGFKQ- 292

Human   342 RLRKRTFILMYLWFTDSVLYQGLILH----MGATSGNLYLDFLYS-------------------- 382
              .|..|...||    ::..|...||    |...|..|:|..:::
  Fly   293 --LKPMFSSPYL----AISLQVYCLHFCQIMCVNSVRLWLPQIFATMNAMDTLGANDTSMCAVLE 351

Human   383 -----------------ALVEIPGAFIALITIDRVGR-----IYPM----AMSNLLAGAACLVMI 421
                             ||...|.:::..||:..:|.     |:|:    .:||.:......:.|
  Fly   352 HNANAKSMDEEEKRVECALHHDPDSYLNNITVAGIGLVGFLIIFPLMRFQVVSNHILKVFLFICI 416

Human   422 FISPDLHWL--NIIIMCVGRMGIT---IAIQMICLVNAELYPTFVRNLGVMVCSSLCDIGGI--- 478
            |:...|:::  :::.|.|..:.:|   |....|..::..::||.:|.:.:::..:...:|.:
  Fly   417 FLVGSLYFVKTSLVTMMVSAVYLTMMGICATTIIGMSVVIFPTLMRTMVLLLIMTFGRLGSVSGN 481

Human   479 -----------ITPFI 483
                       :.||:
  Fly   482 MLLPVFMQLSCLAPFL 497

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A1	XP_005267160.1	2A0119	12..500	CDD:273328	87/471 (18%)
CG14691	NP_650012.2	synapt_SV2	2..>337	CDD:130366	63/309 (20%)
		MFS	<375..513	CDD:475125	21/123 (17%)