Protein Alignment SLC22A1 and CG44098

DIOPT Version :10

• Sequence 1: XP_005267160.1
• Gene: SLC22A1 / 6580
• HGNCID: 10963
• Length: 573
• Species: Homo sapiens
• Sequence 2: NP_001262264.1
• Gene: CG44098 / 40590
• FlyBaseID: FBgn0264907
• Length: 813
• Species: Drosophila melanogaster
• Alignment Length: 580
• Identity: 132/580 - (22%)
• Similarity: 240/580 - (41%)
• Gaps: 87/580 - (15%)

Human     4 VDDILEQVGESGWFQKQAFLI--LCLLSAAFAPICVGIVFLGFTPDH---HCQSPGVAELSQRCG 63
            ||.:.:..|..|.:|.:..|:  ||.:.:::...|  |:|....|.|   .|:.|.......:..
  Fly   206 VDAVGQITGPWGKWQLRTVLLIFLCKIPSSWFMAC--IIFTAPAPRHGEFFCKPPHTIGAQNQTQ 268

Human    64 W----------SPAEELNYTVPGLGPAGEAFLGQCRRYEVDWNQSALSCVDPLASLATNRSHLPL 118
            |          |..:|.:.....:....:........|| :.:|.......||     :|:...:
  Fly   269 WIKVSHPQKEESDDQEFSIDFCNVYQDAQEHAHHYYNYE-NSDQEPRVWEKPL-----HRNSNVI 327

Human   119 GPCQDGWVYDTPGSSIVTEFNLVCADSWKLDLFQSCLNAGFLFGSLGVGYFADR----FGRKLCL 179
             ||.: :.:::...|:||:::|||:    .|:..|......|||.|..|..|::    |..:..:
  Fly   328 -PCTE-FQHESDYHSVVTQYDLVCS----RDILVSVTQFFHLFGVLTGGILANQLLKYFSPRNVM 386

Human   180 LGTVLVNAVSGVLMAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSRRTVAIMYQMAF 244
            |..::.....|.|.....:|...:.||.|..:.....:.||..::.:..|...|..|:.:::..:
  Fly   387 LFGMITQIFCGNLTGHVASYELHVFFRCLSAVCCAQMYTAGGQIMADITGGKYRTCVSTLFEQFW 451

Human   245 TVGLVALTGLAYALPHWRWLQLAVSLPTFLFLLYYW-CVPESPRWLLSQKRNTEAIKIMDHIAQK 308
            ::|::.|.|:|.....|..|.:|:|.|| :.|:|.| .:|:|||||:::.|..:|.||:....:.
  Fly   452 SIGVMMLPGVASFWSSWSHLYMAISWPT-VILIYLWQWIPDSPRWLIARGRTQDAKKILLECVEV 515

Human   309 NG---KLPPADLKMLSLEEDVTEKLSP--SFADLFRTPRLRKRTFILMYLWFTDSVLYQGLILHM 368
            ||   .||....:.|.|:........|  .:..:::..|..:....:...|....|:|.|::|::
  Fly   516 NGTGYNLPHDIDQQLELQAQTAMDAPPPSGWWSMWKGERAVRHIVCVHLAWSLYIVVYYGMLLNI 580

Human   369 GATS-GNLYLDFLYSALVEIPGAFIALITIDRVGRIYP-MAMSNLLAG--AAC--LV----MIFI 423
            .:.| .:||::..::...|:.|.|..|..|.:..|.:. ..:.|::||  |.|  ||    :|.:
  Fly   581 RSFSRDHLYINTFFAGFSEMMGTFFGLFLILKTTRKWLWTGLFNIVAGCIAYCGWLVPKPSVIGL 645

Human   424 SPDLHWLNIIIMC---VGRMGITIAIQMICLVNAELYPTFVRNLGVMVCSSLCDIGGIITPFIVF 485
            .|::    .::||   |.:|.|:..:.::.....||               :.|....||.|...
  Fly   646 DPNV----ALLMCSAMVSKMAISTTLSILTTCTVEL---------------VSDDKKKITSFSTI 691

Human   486 RLREVW-QALPLI----LFGQRTSKT----------LLTHLIEDNSCWLFAEPAMPGHSG 530
            .....| ...|.|    :|||...:|          |.|.||........:.|:.|...|
  Fly   692 CWARFWLLGAPFIGSTVVFGQLIPQTAFASLAILGGLCTSLISSPRTHPISRPSSPAAQG 751

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A1	XP_005267160.1	2A0119	12..500	CDD:273328	119/530 (22%)
CG44098	NP_001262264.1	MFS_SLC22	329..732	CDD:340875	102/427 (24%)