Protein Alignment SLC22A1 and CG7458

DIOPT Version :10

• Sequence 1: XP_005267160.1
• Gene: SLC22A1 / 6580
• HGNCID: 10963
• Length: 573
• Species: Homo sapiens
• Sequence 2: NP_649374.1
• Gene: CG7458 / 40441
• FlyBaseID: FBgn0037144
• Length: 572
• Species: Drosophila melanogaster
• Alignment Length: 518
• Identity: 154/518 - (29%)
• Similarity: 244/518 - (47%)
• Gaps: 46/518 - (8%)

Human     3 TVDDILEQVGESGWFQKQAFLILC---LLSAAFAPICVGIVFLGFTPDHHCQSPGVAELSQRCGW 64
            ::|.||.::|:.|.:|...:::||   |.:|.|:   :..||...|..|.|..|       :|.
  Fly    37 SLDAILVRIGQFGRYQIINYVLLCVPMLFNAFFS---ISYVFTASTVVHRCTVP-------QCD- 90

Human    65 SPA---EE--LNYTVPGLGPAGEAFLGQCRRYEVDWNQSALSCVDP-----LASLATNRSHLPLG 119
            ||:   ||  |.:|:|....|.:    .|.||..:.:.:.....||     |....|..|.
  Fly    91 SPSSVYEEDWLGFTIPKKNSAWD----DCHRYAANISDAISGYTDPSGQYCLKEYFTITSE---- 147

Human   120 PCQDGWVYDTPGSSIVTEFNLVCADSWKLDLFQSCLNAGFLFG-SLGVGYFADRFGRKLCLLGTV 183
            .|...:.:.....:|.|||.:.|.|.|||.:..:..|.|...| .|| ||||||:||:..|....
  Fly   148 TCGRDFKFRDEEKTISTEFGIYCEDEWKLSMVGTINNVGQFVGIPLG-GYFADRYGRRTMLAVAG 211

Human   184 LVNAVSGVLMAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSRRTVAIMYQMAFTVGL 248
            .|:|:.||:.:.|.||...|:|..|...|....:...:.|..|.||...|...|.:..:.:.:|.
  Fly   212 SVSALMGVIRSLSSNYSMFLVFEFLDMAVGSTLFPTAFLLAIELVGPKRRVAAATIITIFYALGE 276

Human   249 VALTGLAYALPHWRWLQLAVSLPTFLFLLYYWCVPESPRWLLSQKRNTEAIKIMDHIAQKNGK-L 312
            ..|..||..:.|||||...:..|..|.:|:.|.:|||.||||||....:|..::...|:.|.: |
  Fly   277 AFLGFLASQVQHWRWLLRVLYAPAVLQILFLWILPESVRWLLSQGAEEKASNVLRRAARINQRPL 341

Human   313 PPADLKMLSLEEDVTEKLSPSFADLFRTPRLRKRTFILMYL------WFTDSVLYQGLILHMGAT 371
            |...|..|....  .:|||.  |:..:.|.:|...|..:.:      |||.:::..||.|:....
  Fly   342 PEEQLNDLLTSN--RQKLSQ--ANESQYPIMRAVVFFSLRIANCCLCWFTHTLIALGLSLNSVNL 402

Human   372 SGNLYLDFLYSALVEIPGAFIALITIDRVGRIYPMAMSNLLAGAACLVMIFISPDLHWLNIIIMC 436
            .||.|.:|:.:..::|||..:.|:.:|||||.:.:..|.||..........:..|.:..::.:..
  Fly   403 GGNKYTNFMLNGFIQIPGLLLPLVIMDRVGRRHSLCASMLLCAICMGASAAVPADNYAGSLALFL 467

Human   437 VGRMGITIAIQMICLVNAELYPTFVRNLGVMVCSSLCDIGGIITPFIVFRLREVWQALPLILF 499
            :|::.||.:.|::....:|::||.|||..:.:||.:..||.::.|.... |.:.:...|.|||
  Fly   468 IGKLAITCSFQILYFFTSEIFPTNVRNTLLSLCSMVGRIGSMLAPQTPL-LAKYYIYAPQILF 529

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A1	XP_005267160.1	2A0119	12..500	CDD:273328	151/509 (30%)
CG7458	NP_649374.1	MFS_SLC22	150..544	CDD:340875	119/386 (31%)