Protein Alignment SLC22A1 and SLC22A

DIOPT Version :9

• Sequence 1: XP_005267159.1
• Gene: SLC22A1 / 6580
• HGNCID: 10963
• Length: 610
• Species: Homo sapiens
• Sequence 2: NP_649370.1
• Gene: SLC22A / 40437
• FlyBaseID: FBgn0037140
• Length: 568
• Species: Drosophila melanogaster
• Alignment Length: 567
• Identity: 166/567 - (29%)
• Similarity: 250/567 - (44%)
• Gaps: 60/567 - (10%)

Human     3 TVDDILEQVGESGWFQKQAFLILCLLSAAFAPICVGIVFLGFTPDH-----HCQSPGVAELSQRC 62
            |:|.||:.:|:.|.||...||::||.....|...|..||...|..|     .|..||........
  Fly    26 TLDAILKHLGQFGRFQLIIFLLICLPMMFHAMFSVTYVFTAATVTHRCSVEECDLPGSNYYEPHT 90

Human    63 GWSPAEELNYTVPGLGPAGEAFLGQCRRYE----VDWNQSALSC-VDPLASLATNRSHLPLGPCQ 122
            .||        :|..|..    |..|.||.    ..||.|...| .|.........:|
  Fly    91 NWS--------IPKNGKD----LDSCNRYTNSELPQWNHSVDICSADHFTKNKEACAH------- 136

Human   123 DGWVYDTPGSSIVTEFNLVCADSWKLDLFQSCLNAGFLFGSLGVGYFADRFGRKLCL-LGTVLVN 186
            :.:|:.....:|..:|.:.|.|.|||.:..:..|.|..||....|:.|||:||...: ||.:| .
  Fly   137 NEFVFRDDEVTISNDFGIFCDDEWKLSMVGTINNLGQFFGIPIGGFVADRYGRSFSIALGGIL-G 200

Human   187 AVSGVLMAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSRRTVAIMYQMAFTVGLVAL 251
            ||.||:.:|||:|...|:|..|..:.|...:...:.:..|.||...|.....:..:.:.||.|.|
  Fly   201 AVLGVIRSFSPSYGWFLVFEFLDNMTSSTLYSTCFVIGIELVGPKRRVLACSVITVFYAVGEVLL 265

Human   252 TGLAYALPHWRWLQLAVSLPTFLFLLYYWCVPESPRWLLSQKRNTEAIKIMDHIAQKNGK-LPPA 315
            ...|.|...||.|......|:.:.|.|:|.:|||.||||||.:...|..|:...|..|.: ||.:
  Fly   266 AMSAKAFHDWRILLRITYGPSLILLAYFWILPESVRWLLSQGKEERAKNILRRAAHVNKRELPES 330

Human   316 DL-KMLSLEEDVTEKLSPS---FADLFRTPRLRKRTFILMYLWFTDSVLYQGLILHMGATSGNLY 376
            .| |::....|..::.|.|   ..:.|:..:.|.....|  .|....::|.||.|::....|:.|
  Fly   331 VLDKLVLANRDKLQQSSESRFPIREAFKNFKWRIANCSL--CWIVHVLVYYGLSLNVVLLDGDKY 393

Human   377 LDFLYSALVEIPGAFIALITIDRVGRIYPMAMSNLLAGAACLVMIFISPDLHWLNIIIMCVGRMG 441
            .:|.|.|||||||.|:.|:.:||.||.|.:....|.:|..|:..||...|...|.:::..||::.
  Fly   394 NNFAYIALVEIPGFFMPLLIMDRFGRRYSLCGLMLASGLCCIGTIFTGADQPVLQLVLFLVGKLT 458

Human   442 ITIAIQMICLVNAELYPTFVRNLGVMVCSSLCDIGGIITPFIVFRLREVWQALPLILFEKQS--- 503
            ||.:.|::....:|:|||.:||..:..||.:...|.::.|.... |.:.:...|.:||...:
  Fly   459 ITASFQVLYFFASEIYPTNLRNSLLSFCSMMGRFGSMLAPQTPL-LAKYYANAPAMLFAGAAIVS 522

Human   504 -------PKKTRFTLRSKPQNPRAPERDVLRRCRVGGMKMELSSAEI 543
                   |:.|...|.:..|     |.|.:      |:|.:..|.::
  Fly   523 GLLTLFFPETTNVVLPTTVQ-----EADAI------GVKKQSKSKDL 558

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A1	XP_005267159.1	2A0119	12..499	CDD:273328	151/502 (30%)
		MFS	118..484	CDD:119392	118/371 (32%)
SLC22A	NP_649370.1	2A0119	35..540	CDD:273328	156/527 (30%)
		MFS	146..530	CDD:119392	121/387 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153733
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.960