Protein Alignment SLC22A1 and CG42269

DIOPT Version :10

• Sequence 1: XP_005267160.1
• Gene: SLC22A1 / 6580
• HGNCID: 10963
• Length: 573
• Species: Homo sapiens
• Sequence 2: NP_648019.2
• Gene: CG42269 / 38689
• FlyBaseID: FBgn0259164
• Length: 662
• Species: Drosophila melanogaster
• Alignment Length: 512
• Identity: 151/512 - (29%)
• Similarity: 243/512 - (47%)
• Gaps: 40/512 - (7%)

Human     5 DDILEQVGESGWFQKQAFLILCLLSAAF--APICVGIVFLGFTPDHH-CQSPGVAELSQRCGWSP 66
            ||||..:||.|.:||  .|.:|::..:|  |.:....:||...|:.| |..|   ||.   |...
  Fly    73 DDILPLIGEFGRYQK--LLFICMIPFSFFVAFVYFSQIFLTLIPEQHWCHVP---ELD---GLDV 129

Human    67 AEELNYTVPGLGPAGEAFLGQCRRYEVDWNQ---SALSCVDPLASLATNRSHLPLGPCQDGWVY- 127
            ...|..::|...  ||  ...|..|:|::..   ......||         ..|...|:.||.|
  Fly   130 EARLALSIPMTN--GE--YNNCYMYDVNYTDILAQGKVMADP---------KWPQVKCRHGWSYN 181

Human   128 --DTPGSSIVTEFNLVCADSWKLDLFQSCLNAGFLFGSLGVGYFADRFGRKLCLLGTVLVNAVSG 190
              :.|.:::.||.|.||.|:......||....|.:.|.|..|:.||||||...|:||.::..::|
  Fly   182 FTEIPYATVATEQNWVCDDAALPTYAQSIFFLGAIVGGLLFGWVADRFGRIPALIGTNMMGLLAG 246

Human   191 VLMAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSRRTVAIM-YQMAFTVGLVALTGL 254
            |..||..|:....:.|...|......:...|.|:.|:||...|..||.| ..:.||.....|..:
  Fly   247 VGTAFVSNFWEFAIMRFFVGFAFDNCFTMMYILVLEYVGPKYRTFVANMSIAIFFTGAACLLPWI 311

Human   255 AYALPHWRWLQLAVSLPTFLFLLYYWCVPESPRWLLSQKRNTEAIKIMDHIAQKNGK-LPPADLK 318
            ||.|..|:.|.:..|.|..|.:...:.||||.|||:||.:..:|:.|:..:.:.||: :||...:
  Fly   312 AYFLADWKLLAIVTSAPLLLAIFTPFVVPESARWLVSQGKVDKAVGILKKLEKGNGRQVPPQTYQ 376

Human   319 MLS-----LEEDVTEKLSPSFADLFRTPRLRKRTFILMYLWFTDSVLYQGLILHMGATSGNLYLD 378
            :.:     ::|...:....|..|||::||||:.|.:|:.:|...|:::.|.:.::|:...:::..
  Fly   377 IFTDSCKRMQEQEAQNGKYSVLDLFKSPRLRRTTLLLIVIWMAISLVFDGHVRNVGSLGLDIFFT 441

Human   379 FLYSALVEIPGAFIALITIDRVGRIYPMAMSNLLAGAACLVMIFISPDLHWLNIIIMCVGRMGIT 443
            |..:...|:|...:..:.:||.||.:....|.:|:|...|:...:...::...:.||  ||..:.
  Fly   442 FTLACFTELPADTLLTVILDRFGRRWLACSSMVLSGVFSLLATVVPVGIYSAALAIM--GRFFVN 504

Human   444 IAIQMICLVNAELYPTFVRNLGVMVCSSLCDIGGIITPFIVFRLREVWQALPLILFG 500
            |:..:.....||:.||.||...|.....:..:..||.||:|: |..:.||||||:.|
  Fly   505 ISYNIGLQWAAEVLPTVVRAQAVAFIHIMGYVASIIAPFVVY-LANISQALPLIILG 560

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A1	XP_005267160.1	2A0119	12..500	CDD:273328	146/503 (29%)
CG42269	NP_648019.2	2A0119	80..552	CDD:273328	140/495 (28%)