Protein Alignment SLC22A1 and CG10486

DIOPT Version :10

• Sequence 1: XP_005267160.1
• Gene: SLC22A1 / 6580
• HGNCID: 10963
• Length: 573
• Species: Homo sapiens
• Sequence 2: NP_647998.2
• Gene: CG10486 / 38664
• FlyBaseID: FBgn0035647
• Length: 706
• Species: Drosophila melanogaster
• Alignment Length: 609
• Identity: 143/609 - (23%)
• Similarity: 259/609 - (42%)
• Gaps: 83/609 - (13%)

Human     5 DDILEQVGESGWFQKQAFLIL---CLLSAAFAPICVGIVFLGFT-PDHHCQSPGV----AELSQR 61
            ||:|..:|:.|.||.:.||.:   |.::|.   :.:|.:|:..| |.::|..|.:    .||.:.
  Fly    97 DDLLPMIGQFGRFQIRLFLFMIPFCFITAF---VYLGQIFMCLTPPKYYCYVPELLHTPVELRKE 158

Human    62 CGWSPAEELNYTVPGLGPAGEAFLGQCRRYEVDWNQSALSCVDPLASLATNRSHLPLGPCQDGWV 126
            ......::.:|:             :||.|..::.:...: .:|.|.:.|:   ||..||:.|:|
  Fly   159 LSIPKEKDGSYS-------------RCRMYNTNYTKIHFA-ENPSAYINTS---LPTIPCKKGYV 206

Human   127 YDTPG---SSIVTEFNLVCADSWKLDLFQSCLNAGFLFGSLGVGYFADRFGRKLCLLGTVLVNAV 188
            ::..|   .|...||..:|.|.......|.....|.:.|.|..|:|||..||...|:.:..:..|
  Fly   207 FEQEGRAFESATMEFGWLCDDDKYATYAQIIFFLGSILGGLAYGHFADHCGRVAALVSSCFLALV 271

Human   189 SGVLMAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSRRTVA----IMYQMAFTVGLV 249
            ..:..:.|.::.:..:.|.|.|......:...|.|:.|:||...|..||    .::...||   :
  Fly   272 GSLATSMSTDFFTFAISRFLVGASYDTCFTMVYILVLEYVGPKYRTLVANLSLALFYSPFT---M 333

Human   250 ALTGLAYALPHWRWLQLAVSLPTFLFLLYYWCVPESPRWLLSQKRNTEAIKIMDHIAQKNGKLPP 314
            .:..:|.:..:||......|||..|.:..:..:|||.|||:|.....:|::|:.::.:.|.|...
  Fly   334 VMPWIALSAGNWRRFSSFTSLPIVLAMFSFCLLPESARWLVSVGEIDKALEILKNVIEVNKKQVS 398

Human   315 ---ADLKMLSLEEDVTEKLSP---SFADLFRTPRLRKRTFILMYLWFTDSVLYQGLILHMGAT-- 371
               .||...|..:...|:|..   :...:|:..|:.:...:::.:|.:.|::|.|   |:.|.
  Fly   399 KEILDLFEASCTQFYKEELDGRDFTVLSIFKRKRMARYMILMILIWMSISLVYDG---HVRAASV 460

Human   372 --SGNLYLDFLYSALVEIPGAFIALITIDRVGRIYPMAMSNLLAGAACLVMIFISPDLHWLNIII 434
              |.|::|.|..:...|:||..:.::|:||.||.:.......|:|      :|......:.|...
  Fly   461 LDSENIFLFFTIACATELPGNILVILTLDRAGRRWCSFFYTSLSG------VFSLLGASFQNRAN 519

Human   435 M----CVGRMGITIAIQMICLVNAELYPTFVRNLGVMVCSSLCDIGGIITPFIVFRLREVWQALP 495
            |    ..||....|...:.....||:.||.||..||....::..:..:::|.:|:..::...:..
  Fly   520 MRMSALAGRFFSNICYNIGLQWAAEILPTVVRAQGVAFIHTMGFVAMLMSPPVVYLSKKSLSSTL 584

Human   496 LIL-----FGQRTSKTL---LTHLIEDNSCWLFAEPAMPGHSG-------VGPACRGSDATSSRD 545
            ::|     ||...:..|   |.|.:.:.    .::.|..|.:.       .||..|.|....:..
  Fly   585 IVLGALGIFGGLLALFLPETLNHELPET----LSDGAQFGKNQRIWHMPCCGPGSRKSHPRHNWH 645

Human   546 QGGRFARDHEGRREPWEKSKAQRK 569
            ||...   ....::.:..||..||
  Fly   646 QGSSL---RTLSKDEFRSSKMYRK 666

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A1	XP_005267160.1	2A0119	12..500	CDD:273328	123/521 (24%)
CG10486	NP_647998.2	2A0119	104..612	CDD:273328	128/539 (24%)