Protein Alignment SLC22A1 and CG5592

DIOPT Version :10

• Sequence 1: XP_005267160.1
• Gene: SLC22A1 / 6580
• HGNCID: 10963
• Length: 573
• Species: Homo sapiens
• Sequence 2: NP_647996.1
• Gene: CG5592 / 38662
• FlyBaseID: FBgn0035645
• Length: 540
• Species: Drosophila melanogaster
• Alignment Length: 525
• Identity: 139/525 - (26%)
• Similarity: 230/525 - (43%)
• Gaps: 72/525 - (13%)

Human     5 DDILEQVGESGWFQKQAFLILCLLSAA--FAPICVGIVFLGFTPDHH-CQSPGVAELSQRCGWSP 66
            ::.|..:|:.|.|||:  |:..::.||  ||....|.:|:...|.:| |:   |.||.   |...
  Fly    10 ENFLLFIGDFGPFQKR--LLFWMMPAAFLFAFTYFGQIFMILLPKNHWCR---VRELE---GLPE 66

Human    67 AEELNYTVPGLGPAGEAFLGQCRRYEVDWNQSALSCVDPLASLATNRSHLPLGPCQDGWVYD--- 128
            :|:.|..:|   ...:.....|..|.|.::.:|.:        ..|::..|: ||.:||:||
  Fly    67 SEQKNRGIP---KKQDGSFENCFMYNVPYDSNATN--------DANQTRSPI-PCNNGWIYDRKE 119

Human   129 TPGSSIVTEFNLVCADSWKLDL--------FQSCLNAGFLFGSLGVGYFADRFGRKLCLLGTVLV 185
            .|..||.||:|.||.   |.|.        |..|     :.|.|..|:..|..||...|......
  Fly   120 VPYESIATEYNWVCD---KRDFGTYSVVVYFVGC-----IVGCLCFGFITDHSGRLPALFLANSC 176

Human   186 NAVSGVLMAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSRRTVA-IMYQMAFTVGLV 249
            :.:.|.:.....::......|.:.||.....::..|.|..|.||...|..|. :.....||:|..
  Fly   177 SMIGGCVSVVCKDFPCFAASRFVAGLSMNYCFVPIYILTLENVGIKYRTLVGNLALTFFFTLGAC 241

Human   250 ALTGLAYALPHWRWLQLAVSLPTFLFLLYYWCVPESPRWLLSQKRNTEAIKIMDHIAQKNGKLPP 314
            .|..|||.:.:||...:.|:||....:|.....||||.||:|..:....|::|...|:.|||:
  Fly   242 LLPWLAYVISNWRHYAMVVALPIVFMILTSLLAPESPSWLMSVGKVDRCIEVMKEAAKANGKI-- 304

Human   315 ADLKMLSLEEDV-------------TEKLSPSFA--DLFRT-PRLRKRTFILMYLWFTDSVLYQG 363
                   :.|:|             .|:|...:.  |||:| |||...| ||:..|.|.::.|..
  Fly   305 -------ISEEVWSEMRECYELKFANEQLGKQYTSLDLFKTFPRLVVLT-ILIVTWMTVALAYDA 361

Human   364 LILHMGATSGNLYLDFLYSALVEIPGAFIALITIDRVGRIYPMAMSNLLAGAACLVMIFISPDLH 428
            .:..:.....::::.|..|:|||||...:.::.:||:||...|:...||..|:.|.:..:..  |
  Fly   362 HVRVVEILDTDIFITFSLSSLVEIPAGIVPMLLLDRIGRKPMMSAVMLLCAASSLFVGILKG--H 424

Human   429 WLNIIIMCVGRMGITIAIQMICLVNAELYPTFVRNLGVMVCSSLCDIGGIITPFIVFRLREVWQA 493
            |.........|...|:|..:.....:|:.||.:|..|:.:.:.:..:|.:::| :|......::.
  Fly   425 WNASTAAIAARFFATMAYNVGQQWASEILPTVLRGQGLAIINIMGQMGALLSP-LVLSTHRYYRP 488

Human   494 LPLIL 498
            ||:.:
  Fly   489 LPMFI 493

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A1	XP_005267160.1	2A0119	12..500	CDD:273328	138/518 (27%)
CG5592	NP_647996.1	MFS_SLC22	113..509	CDD:340875	107/402 (27%)