Protein Alignment SLC22A1 and CG8654

DIOPT Version :10

• Sequence 1: XP_005267160.1
• Gene: SLC22A1 / 6580
• HGNCID: 10963
• Length: 573
• Species: Homo sapiens
• Sequence 2: NP_611451.1
• Gene: CG8654 / 37275
• FlyBaseID: FBgn0034479
• Length: 502
• Species: Drosophila melanogaster
• Alignment Length: 559
• Identity: 152/559 - (27%)
• Similarity: 247/559 - (44%)
• Gaps: 91/559 - (16%)

Human     3 TVDDILEQVGESGWFQKQAFLILCLLSAAFAPICVGIVFLGFTPDHHCQSPGVAELSQRCGWSPA 67
            |.|.|:.|:|:...:|...|.|:.|.........:|.:||.......|::..|.:
  Fly    20 TGDPIISQIGDFRRYQLFFFFIVLLCKFGTGWHTLGHIFLAAPTPLSCKTENVTD---------- 74

Human    68 EELNYTVPGLGPAGEAFLGQCRRYEVDWNQSALSCVDPLASLATNRSHLPLGPCQDGWVYDTPGS 132
                       |..:    :|...|.|.:                             |:.   |
  Fly    75 -----------PCSD----ECSETEFDTS-----------------------------VFQ---S 92

Human   133 SIVTEFNLVCADSWKLDLFQSCLNAGFLFGSLGVGYFADRFGRKLCLLGTVLVNAVSGVLMAFSP 197
            :|:||:||.|.......|.||.:..|.||||:..|.||||:||:...|....:..::|:::..||
  Fly    93 TIITEWNLTCESKQLASLSQSIVMLGILFGSILFGMFADRYGRRPAFLTCCFMQLITGLIVCVSP 157

Human   198 NYMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSRRTVAIMYQMAFTVGLVALTGLAYALPHWR 262
            .|....|||.|..:.:.|.....:.|:.|.||...|..|||:||:.|.:|..:|...||.:..||
  Fly   158 YYWFYCLFRFLVAVATAGTMTTSFVLLMEIVGPKKREMVAILYQIPFNIGHASLALFAYFIREWR 222

Human   263 WLQLAVSLPTFLFLLYYWCVPESPRWLLSQKRNTEAIKIMDHIAQKNGKLPPADLK--------M 319
            |.|.::::.:.:|::|.|.||||||||.:..:..::|||::.||:.| |.|...::        .
  Fly   223 WFQFSITIFSIVFVIYIWLVPESPRWLFTTGKLDKSIKILEKIAKCN-KAPTETIRPEIEAAYGA 286

Human   320 LSLEEDVTEKLSPSFADLFRTPRLRKRTFILMYLWFTDSVLYQGLILHMGATSGNLYLDFLYSAL 384
            |:..:.|.:   .:..||||||.:|.:|..:...|....::|.|...::.|..||:::....:|.
  Fly   287 LAARQPVKK---GTVVDLFRTPYMRIKTIFMANNWLVVCMVYYGTAQYVSALGGNIFISNAIAAG 348

Human   385 VEIPGAFIALITIDRVGRIYPMAMSNLLAGAACLVMIFISPDLHWLNIIIMCVGRMGITIAIQMI 449
            |.|||..:..:....:||...:.:||..:....:::..:|.....:.:....:|..|.:|....:
  Fly   349 VGIPGTCLCALMTKYLGRKKTLLLSNGCSALGLILLACLSTQAEAVRVTCATIGLFGASITFPNV 413

Human   450 CLVNAELYPTFVRNLGVMVCSSLCDIGGIITPFIV-FRLREVWQALPLILFGQRTSKTLLTHLIE 513
            .|...||:||.||:.||.:||.:..||.|:.|.|| .....:|.| ||| ||
  Fly   414 YLYGGELFPTVVRSSGVGLCSMVGRIGSIVAPLIVDLAAYGLWVA-PLI-FG------------- 463

Human   514 DNSCWLFAEPAMPGHSGVGPACRGSDATSSRDQGGRFAR 552
                 :|:..||.|...: |..||:....:.:.|..|.|
  Fly   464 -----IFSILAMLGTIFL-PETRGTPLPETLEDGETFGR 496

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A1	XP_005267160.1	2A0119	12..500	CDD:273328	136/496 (27%)
CG8654	NP_611451.1	MFS_SLC22	82..477	CDD:340875	130/451 (29%)