Protein Alignment SLC22A1 and CG4630

DIOPT Version :10

• Sequence 1: XP_005267160.1
• Gene: SLC22A1 / 6580
• HGNCID: 10963
• Length: 573
• Species: Homo sapiens
• Sequence 2: NP_001260948.1
• Gene: CG4630 / 36458
• FlyBaseID: FBgn0033809
• Length: 582
• Species: Drosophila melanogaster
• Alignment Length: 549
• Identity: 166/549 - (30%)
• Similarity: 262/549 - (47%)
• Gaps: 68/549 - (12%)

Human     5 DDILEQVGESGWFQKQAFLILCLLSAAFAPICVGIVFLGFTPDHHCQSP---GVAELSQRCGWSP 66
            ||||.::||.|.||::.:|::||.....|...:..||...:|.:.|..|   .:.:......|
  Fly    16 DDILVEIGEFGRFQRRNYLLICLPVLFAAANSLSYVFTAGSPTYRCYVPECDKLVDAEYGANW-- 78

Human    67 AEELNYTVPG-LGPAGEAFLGQCRRYEVDWNQSALSCVDPLASLATNRSHLPLGPC--------- 121
               ::..||| ....|......|.|:..:.        |.|.|.:...|..||..|
  Fly    79 ---VSIAVPGSWSKRGHFTPSTCERFVANG--------DHLESSSDPWSAWPLDQCFAENFTTET 132

Human   122 --QDGWVYDTPGSSIVTEFNLVCADS-WKLDLFQSCLNAGFLFGSLGVGYFADRFGRKLCLLGTV 183
              .:.:||.:...:||.::.|.|.:: |||....:...||.:.|:...||.|||:|||...|..:
  Fly   133 ERCNQFVYGSSERTIVQQWGLQCPENLWKLAFVGTIHFAGLVVGTALSGYLADRYGRKHIFLFCI 197

Human   184 LVNAVSGVLMAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSRRTVAIMYQMAFTVGL 248
            :..|::||..|.|.:|:|.|.|.||..:.:.|.:...:.:..|.||...|...:|:....:.||
  Fly   198 VFMALTGVAQALSWDYISFLFFALLNAVGTSGVYPLAFIIGVEMVGPRKREMSSIVLNYFYAVG- 261

Human   249 VALTGLAYALPHWRWLQLAVSLPTFLFLLYYWCVPESPRWLLSQKRNTEAIKIMDHIAQKNGKLP 313
            .||.||:..||.||.||||:|:|..:.:.|:|.||||.||||::.|..:|..|:...|:.|.:..
  Fly   262 EALLGLSVFLPDWRQLQLALSVPPLICVAYFWLVPESVRWLLARNRREQAGVIIRRAAKVNRRDI 326

Human   314 PADL----KMLSL------EEDV--------TEKLSPSFADLFRTPRLRKRTFILMYLWFTDSVL 360
            ..:|    |...|      |:||        .:|:..:..::.|:..|..|..||:.:|..::::
  Fly   327 SVELMASFKQQELDAETGQEDDVEGGLHVKKDDKIWLAVKEVARSHILMGRYAILLLIWAVNAIV 391

Human   361 YQGLILHMGATSGNLYLDFLYSALVEIPGAFIALITIDRVGRIYPMAMSNLLAGAACLVMIFIS- 424
            |.||.|:..:.|||.||:|....||||||..:|.:.:.|.||...::.|.||....|:...|::
  Fly   392 YYGLSLNATSLSGNKYLNFALVCLVEIPGYSLAWLFLRRFGRRVALSGSLLLCSITCVASGFVTL 456

Human   425 ------------------PDLHWLNIIIMCVGRMGITIAIQMICLVNAELYPTFVRNLGVMVCSS 471
                              ...:||.:.:..||::|||.:..:|....||:.||.:|:.||.|.|:
  Fly   457 AQGDWIPCQTGVESRHSWSCANWLVVTLFLVGKLGITSSFAVIYTFTAEMMPTVIRSGGVGVMST 521

Human   472 LCDIGGIITPFIVFRLREVWQALPLILFG 500
            ....|.::.||:.. |...:..|||:|||
  Fly   522 FARFGAMLAPFVPL-LASYYDPLPLLLFG 549

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A1	XP_005267160.1	2A0119	12..500	CDD:273328	160/540 (30%)
CG4630	NP_001260948.1	2A0119	23..573	CDD:273328	162/542 (30%)