Protein Alignment SLC22A1 and CarT

DIOPT Version :9

• Sequence 1: XP_005267159.1
• Gene: SLC22A1 / 6580
• HGNCID: 10963
• Length: 610
• Species: Homo sapiens
• Sequence 2: NP_610052.1
• Gene: CarT / 35334
• FlyBaseID: FBgn0032879
• Length: 674
• Species: Drosophila melanogaster
• Alignment Length: 520
• Identity: 159/520 - (30%)
• Similarity: 254/520 - (48%)
• Gaps: 45/520 - (8%)

Human     4 VDDILEQVGESGWFQKQAFLILCLLSAAFAPICVGIVFLGF-------TPDHH-CQSPGVAE--L 58
            :||:|..:||.|.:||.....:||      |.|:...|..|       |||.: |:.|.:.:  |
  Fly    36 LDDLLPTIGEFGKYQKLLVFGICL------PACIPCGFCAFNQLFMADTPDDYWCRIPELLDLPL 94

Human    59 SQRCGWSPAEELNYTVPGLGPAGEAFLGQCRRYEVDWNQSALSC-VDPLASLATNRSHLPLGPCQ 122
            .||...|..:||:        ..|....:|..|.|:|.|...|. .|.|.::..|.| .||..|.
  Fly    95 EQRKSLSIPKELD--------NDELVYSKCYTYGVNWTQLLESGEEDDLTTMEPNAS-WPLIKCP 150

Human   123 DGWVYDTP--GSSIVTEFNLVCADSWKLDLFQSCLNAGFLFGSLGV---GYFADRFGRKLCLLGT 182
            .||.|:|.  .||||.:|:|||.......:..:.||.|   |.:||   |...||.||:|... .
  Fly   151 QGWEYNTSVVWSSIVIDFDLVCDQDIYPTIGLAALNTG---GPVGVYLFGLLNDRGGRRLSYF-V 211

Human   183 VLVNAVSGVLM-AFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSRRTVAIMYQMAFTV 246
            .|...::|.|| :.|.::.:....|::.||.....:...:.:..|.||...|..|.:|....:|.
  Fly   212 CLATLLAGSLMTSLSKDFWTWAGSRVIVGLTIPAVYQIPFIISLELVGENYRSFVTVMTCTFYTS 276

Human   247 GLVALTGLAYALPHWRWLQLAVSLPTFLFLLYYWCVPESPRWLLSQKRNTEAIKIMDHIAQKNGK 311
            |::.|:|:.|....|..|....|||.:.:.||.:.:||||||||.:.|..||:||::.:|:.||:
  Fly   277 GIMLLSGVTYLERDWVRLSYITSLPFYAYFLYMFVMPESPRWLLMRGRLEEALKILERMAKVNGR 341

Human   312 LPP--------ADLKMLSLEEDVTEKLSPSFADLFRTPRLRKRTFILMYLWFTDSVLYQGLILHM 368
            ..|        |.::...|::...:..:...|||.|||.:|.:|.::...||.:..:|.||..:.
  Fly   342 EFPEAVHLKLEAQIRRDKLKKQKKKMANVGLADLCRTPNMRLKTILITLSWFANETVYLGLSYYG 406

Human   369 GATSGNLYLDFLYSALVEIPGAFIALITIDRVGRIYPMAMSNLLAGAACLVMIFISPDLHWLNII 433
            .|...|.|:.|..||:||:|........:|..||.:|:::|.:|.|.||::.:.:..|.....::
  Fly   407 PALGTNQYVSFFLSAVVELPSYLCCWYFMDTWGRRWPLSLSMILGGVACVITVMLPDDAVDETLV 471

Human   434 IMCVGRMGITIAIQMICLVNAELYPTFVRNLGVMVCSSLCDIGGIITPFIVFRLREVWQALPLIL 498
            :..|.:..::.:..:|.....|||||.||.:|:...|.:..:|.|..|||.:..::..: |||::
  Fly   472 LYLVSKALLSASFLIIYPFAGELYPTQVRGIGIGASSYIGGLGLIGIPFITYLGKDNLK-LPLVI 535

Human   499  498
              Fly   536  535

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A1	XP_005267159.1	2A0119	12..499	CDD:273328	156/512 (30%)
		MFS	118..484	CDD:119392	118/379 (31%)
CarT	NP_610052.1	2A0119	44..561	CDD:273328	156/512 (30%)
		MFS	182..551	CDD:119392	108/359 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	6.020