DRSC/TRiP Functional Genomics Resources

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Protein Alignment SLC22A1 and CG31272

DIOPT Version :10

Sequence 1:XP_005267160.1 Gene:SLC22A1 / 6580 HGNCID:10963 Length:573 Species:Homo sapiens
Sequence 2:NP_650013.3 Gene:CG31272 / 326130 FlyBaseID:FBgn0051272 Length:563 Species:Drosophila melanogaster


Alignment Length:481 Identity:108/481 - (22%)
Similarity:189/481 - (39%) Gaps:104/481 - (21%)


- Green bases have known domain annotations that are detailed below.


Human   120 PCQDGWVYDTPGSSIV-----TEFNLVCADSWKLDLFQSCLNAGFLFGSLGVGYFADRFGRKLCL 179
            |.|...::::...|.:     .:..|...|...|:   :...||....::..||.||..|||..|
  Fly    67 PAQSAAIFESSSMSYILPIAECDLRLTLEDKGVLN---AVAYAGMTISAIAWGYLADTKGRKKIL 128

Human   180 LGTVLVNAVSGVLMAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSRRTVAIMYQMAF 244
            ....|::||.....|.|.|:..:::|:.|.|||..|.....:|.:||..|...|.:|.::..|..
  Fly   129 YWGYLIDAVCVFGSALSQNFSMLVMFKFLGGLVVNGPAAVLFTYLTEMHGPKHRSSVLMIVGMVT 193

Human   245 TVGLVALTGLAYAL-PH-------------WRWLQLAVSLPTFLFLLYYWCVPESPRWLLSQKRN 295
            :...|:|..||:.: |.             |:.....:.:|:.:..|.:..:|||||:|::|.||
  Fly   194 STATVSLPLLAWGIFPRDWDFEFWGLQVHSWQIFLFVLGIPSLISGLIFCSMPESPRFLMAQGRN 258

Human   296 TEAIKIMDHIAQKNGKLPPADLKMLSLEEDV----------------------TEKLSPSFADLF 338
            .||::....|...|.:.|.....:.:|.::|                      |::.|.:.|:..
  Fly   259 EEALQAFKQIYHVNTRKPKDSYPIKALIQEVPNRKAAQNEVIYTIEEKSGEVPTKRQSRTLAESL 323

Human   339 RT------PRLRKRTFILMYLWFTDSVLYQGLILHMGATSGNLYLDFLYSALVEI------PGAF 391
            |.      |.:||.   |:.|.....|:..|:.|  |..:..|:|..|::::.|.      .|..
  Fly   324 RAGLQQMKPLVRKP---LLGLAICCYVMQFGIFL--GMNTIRLWLPQLFASMAEYEALHAGDGLD 383

Human   392 IALITIDRVGRIYPMAMSNLLAGAACLVMIFISPDLHWLNIIIMCVGRMG--------------- 441
            :::.||.... :...|.:.|....||.....||.|::..|||:...|.:|               
  Fly   384 VSMCTILEFS-VNQTAETALNYADACSEPKVISMDMYLNNIIVSATGFVGYFFAGGILRALGPKR 447

Human   442 -----------------ITIAIQMICLVNAELYPTFVRNLGVMVCSSLCDIGGIITPFIVFRLRE 489
                             .:::..|..:|:|    ||:...|:.|.|.|    |.:......:||.
  Fly   448 MMTYGLFLSGTFGLMLYFSVSSLMTLIVSA----TFLTITGIAVSSLL----GAVVALFPTQLRT 504

Human   490 VWQALPLIL--FGQRTSKTLLTHLIE 513
            |..|:.::.  ||..:...|....::
  Fly   505 VVVAIAMMCGRFGALSGNLLFPVFVQ 530

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SLC22A1XP_005267160.1 2A0119 12..500 CDD:273328 105/466 (23%)
CG31272NP_650013.3 synapt_SV2 15..556 CDD:130366 108/481 (22%)

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