Protein Alignment SLC22A1 and CG15221

DIOPT Version :10

• Sequence 1: XP_005267160.1
• Gene: SLC22A1 / 6580
• HGNCID: 10963
• Length: 573
• Species: Homo sapiens
• Sequence 2: NP_001096957.1
• Gene: CG15221 / 32127
• FlyBaseID: FBgn0030331
• Length: 545
• Species: Drosophila melanogaster
• Alignment Length: 483
• Identity: 115/483 - (23%)
• Similarity: 200/483 - (41%)
• Gaps: 120/483 - (24%)

Human   113 RSHLPL----GPCQDGWVYDTPGSSIVTEFNLVCADSWKLDLFQSCLN-------AGFL---FGS 163
            |.|..|    |.|..|.:.:..|.|::       .:..|.|| |..||       ||||   ..|
  Fly    45 RFHYKLLLICGLCFMGVMVEIMGVSLI-------MNQMKCDL-QPTLNQQGILASAGFLGVVLSS 101

Human   164 LGVGYFADRFGRKLCLLGTVLVNAVSGVLMAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEFV 228
            ..:|:.||.:||...|...:.:::|..::.|||.|...:::||.|.|....|.....::|..||.
  Fly   102 HAMGFLADTWGRATTLRYALCISSVCSIVSAFSVNIWMLIVFRFLTGFFISGGQACVFSLCGEFH 166

Human   229 GSGSR----------RTVAIMYQMAFTVGLVAL------TGLAYALPHWRWLQLA-VSLPTFLFL 276
            |:|||          ..:|:::..|..:|::.|      .|:.::  .||.|.|| ||:| .|.|
  Fly   167 GTGSRIRHVTLLSGFLCMAMIFAPAMAIGILPLRIETIVLGMHFS--SWRVLLLANVSIP-LLAL 228

Human   277 LYYWCVPESPRWLLSQKRNTEAIKIMDHIAQKNGKLPPAD--LKMLSLEED-------------- 325
            :....:||:|::||.|.|..|:::::..|...|....|::  :|.::||..
  Fly   229 VGISALPETPKYLLVQGRGDESLEVLRSIFANNSGRDPSEYPVKEVALESGGVSLSDVHGFLDAV 293

Human   326 --VTEKLSPSF--ADLFRTPRLRKRTFIL------MYLWFTD---------------SVLYQGLI 365
              |..:..|.|  |.|:.|..:....||:      :::||..               ..:.||..
  Fly   294 RLVWHQTVPLFYRARLWHTLNICCIQFIIYFLAQGIFMWFPTILDELGTRNGENTLLCTVLQGFN 358

Human   366 LHMG----ATSGNLYLD-FLYSALVEIPGAFIAL-----ITIDRVGRIYPMAMSNLLAGAACLVM 420
            ::..    |:|.::.:| ..|..::.|...|:.:     ..||.:|:      .|||.....|.|
  Fly   359 INSSSEDEASSCSVEVDTSTYQVMIIIAACFVVIYLIFAYIIDYMGK------KNLLMAWMVLTM 417

Human   421 IFISPDLHWLN---------IIIMCVGRMGITIAIQMICLVNAELYPTFVRNLGVMVCSSLCDIG 476
            |.:.. ||::.         .::|.:|..|     .::..:..|.|||.:..:|:.....:..:|
  Fly   418 ICLVA-LHYVEQFALVVIALTVVMAIGNCG-----GLVSTIAMEFYPTHINAMGMCFIMMVGRLG 476

Human   477 GIITPFIVFRLREV------WQALPLIL 498
            .::...|:.||...      |..|.|::
  Fly   477 AVVGSNILGRLLFASCDPIFWALLALVV 504

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A1	XP_005267160.1	2A0119	12..500	CDD:273328	115/483 (24%)
CG15221	NP_001096957.1	2A0119	<85..479	CDD:273328	95/408 (23%)