Protein Alignment SLC22A1 and CG3168

DIOPT Version :10

• Sequence 1: XP_005267160.1
• Gene: SLC22A1 / 6580
• HGNCID: 10963
• Length: 573
• Species: Homo sapiens
• Sequence 2: NP_572345.1
• Gene: CG3168 / 31612
• FlyBaseID: FBgn0029896
• Length: 632
• Species: Drosophila melanogaster
• Alignment Length: 557
• Identity: 124/557 - (22%)
• Similarity: 217/557 - (38%)
• Gaps: 130/557 - (23%)

Human    43 GFTPDHHCQSPGVAELSQRCGWSPAEELNYTVP-----GLGPAGEAFLGQCRRYEVDWNQSALSC 102
            |:.||.|..             ...:::....|     |.||.|:...|...|      :.::..
  Fly    81 GYEPDSHAN-------------GKQQDVERDAPDGGHGGHGPPGKGGKGGKGR------KKSVPL 126

Human   103 VDPLASLATNRS------------HLPLGPCQDGWVYDTPGSSIVTEFNLVCADSWKLDL----- 150
            .:|.|.:..|..            ::.|..|  |.|..:....:::...::.:....|||
  Fly   127 PEPTAPIVANFERAIELCGYGKFHYILLAIC--GLVSTSEEMDVISMSFILPSAECDLDLNTETK 189

Human   151 --FQSCLNAGFLFGSLGVGYFADRFGRKLCLLGTVLVNAVSGVLMAFSPNYMSMLLFRLLQGLVS 213
              ..|.:..|.:.|:...|..||.||||..|:....:||...|..:||..|...:|||.|.|...
  Fly   190 GWLNSIIFIGMMVGAYFWGSIADSFGRKKVLIVISFMNAFCIVASSFSQTYSFFMLFRFLNGAAL 254

Human   214 KGNWMAGYTLITEFVGSGSRRTVAIMYQMAFTVGLVALTGLAYAL---------PH-----WRWL 264
            .|:....::...||.....|.::.......:|.|.:.:..||:.:         |:     ||..
  Fly   255 GGSGPVIWSYFAEFQPKAKRGSMLSFMAAFWTFGNLFVASLAWLIIPRTIGFTTPYFTYNSWRIF 319

Human   265 QLAVSLPTFL--FLLYYWCVPESPRWLLSQKRNTEAIKIMDHIAQKNGKLPPADLKMLSLEEDVT 327
            .|..|||:||  |||:|  :||||::||::.:...|:.|...|...|.|..|.:..:..||.|
  Fly   320 LLVCSLPSFLVGFLLFY--LPESPKFLLTRGKKDRALAIFRGIFVTNTKRRPDEYMVYDLEVD-- 380

Human   328 EKLSPSFAD------------------LFRTPRLRKRTFILMYLWFTDSVLYQGLIL-------- 366
            |||..|..:                  ||::|.|| .|.:.:.:.||..:.|.||::
  Fly   381 EKLLESNGNVKNKYSRMISGMVDHSRALFKSPILR-FTIVSITINFTFHIGYYGLLMWFPELFNR 444

Human   367 ------------------------------HMGATSGNL----YLDFLYSALVEIPGAFIALITI 397
                                          :.|..|.::    :::.|.|....:|...:|::.:
  Fly   445 FEEYEKAFPDQSAGVCAVTDYVVNLAKEQSNNGTCSSDIPQSVFMESLISLASALPANLLAILGM 509

Human   398 DRVGRIYPMAMSNLLAGAACLVMIFISPDLHWLNIIIMCVGRMGITIA-IQMICLVNAELYPTFV 461
            |.:||.:.:....:.||....:|.|:...:.  |:::..:....|:.| ..:.||: .|::||.:
  Fly   510 DMLGRKFFLIAGTMTAGICSALMYFVRSSVQ--NLVVSAIFSGAISAANAALDCLI-TEVFPTKL 571

Human   462 RNLGVMVCSSLCDIGGIITPFIVFRLREVWQALPLIL 498
            |..||.:......:||||...::.:|.:.:...|..:
  Fly   572 RATGVAISMVAARLGGIIGNIVIAQLLDNYCPSPTFI 608

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A1	XP_005267160.1	2A0119	12..500	CDD:273328	124/557 (22%)
CG3168	NP_572345.1	synapt_SV2	<137..626	CDD:130366	110/482 (23%)