Protein Alignment SLC22A1 and CG33233

DIOPT Version :10

• Sequence 1: XP_005267160.1
• Gene: SLC22A1 / 6580
• HGNCID: 10963
• Length: 573
• Species: Homo sapiens
• Sequence 2: NP_995978.2
• Gene: CG33233 / 2769005
• FlyBaseID: FBgn0053233
• Length: 489
• Species: Drosophila melanogaster
• Alignment Length: 473
• Identity: 109/473 - (23%)
• Similarity: 189/473 - (39%)
• Gaps: 120/473 - (25%)

Human   125 WVYDTPGSSIVTEFNLVCADSWKLD-------LFQSCLNAGFLFGSLGVGYFADRFGRKLCLLGT 182
            ::|....:..:|...||...|.:.|       |..:.|..|.:...|.:|:.|||:|||. ::..
  Fly    28 FIYMYSVTESMTAGYLVVLTSCEFDTSPKEKTLLANSLLGGMVASGLFIGFLADRYGRKF-VIRL 91

Human   183 VLVNAVS-GVLMAFSPNYMSMLLFRLLQG--LVSKGNWMAGYTLITEFVGSGSRR-TVAIMYQ-- 241
            .||.|:| .|:.|..|:..|:.:.|::.|  |.:..:...|:  :.||.....|. ||||..|
  Fly    92 ALVGALSFSVISALMPDLYSLSVIRIIVGTFLSAVASLQVGF--LGEFHAIKWRPITVAICSQSQ 154

Human   242 -----------MA-----FTVGLVALTGLAYALPHWRWLQLAVSLPTFLFLLYYWCVPESPRWLL 290
                       ||     |.|.|.:    :|.|..||:|.:...:|.:|.|:....|||:|.:|:
  Fly   155 GLALIYCPLVAMAILPNNFNVDLSS----SYNLRVWRFLMMFFMIPGWLALVGICLVPETPHFLM 215

Human   291 SQKRNTEAIKIMDHIAQKNGKLPPADLKMLSLEEDVTEKLSPS-------------FADLFRTPR 342
            |..|..:|:..:..|.:.|.|      |...::..::|:.|.:             :..||..|.
  Fly   216 SVNRPDKALLALKWICRMNRK------KWEDVDITLSEEKSSTNDQEGFWKTVWYEYKLLFSKPH 274

Human   343 LRKRTFILMYL-------------WF--------------TDSVLYQGLILHMGA--TSG----- 373
            :.| .||.::|             ||              .|.|......::..|  |:|
  Fly   275 VFK-FFICLFLIFGIFFTSIGLGIWFPVIRNMDNSGSNRLCDLVNNNPTFINHEADDTNGTDSES 338

Human   374 --------NLYLDFLYSALVEIPGAFI-ALITIDRVGRIYPMAMS---NLLAGAACLVMIFISPD 426
                    || :|.:|.....| |.|| |.:.:..:.|.|.:|:.   :::.|.:..:|  ..|.
  Fly   339 PKCNDEMTNL-IDPVYYGFTYI-GCFILASVLVHWMTRKYVIALHILISMILGISLNIM--KQPT 399

Human   427 LHWLNIIIMCVGRMGITIAIQMICLVNAELYPTFVRNLGVMVCSSLCDIGGI-----------IT 480
            :..:..::|.| ..|:.|.:....||  :..|..:|...:.:..||...||:           :|
  Fly   400 VVLIFFVLMMV-LPGVLIPLATSVLV--DCLPVNLRGKALCMVRSLARFGGVLGSTMIGLFIRVT 461

Human   481 PFIVFRLREVWQALPLIL 498
            ..:.|.:..:..|:.::|
  Fly   462 CDVTFNIFNLCLAICVVL 479

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A1	XP_005267160.1	2A0119	12..500	CDD:273328	109/473 (23%)
CG33233	NP_995978.2	2A0119	<49..>295	CDD:273328	66/259 (25%)