Protein Alignment BMPR1B and sax

DIOPT Version :9

• Sequence 1: NP_001243722.1
• Gene: BMPR1B / 658
• HGNCID: 1077
• Length: 532
• Species: Homo sapiens
• Sequence 2: NP_001246193.1
• Gene: sax / 35731
• FlyBaseID: FBgn0003317
• Length: 582
• Species: Drosophila melanogaster
• Alignment Length: 599
• Identity: 242/599 - (40%)
• Similarity: 329/599 - (54%)
• Gaps: 104/599 - (17%)

Human     6 ELNWQLHIFLLILLSMHTRANFLD---------NMLLRSAGKLNVGTKK-----EDGESTAP--- 53
            |.|..|...|..||..:.||...|         :|.|.||...::..|:     ::...|.|
  Fly     2 ESNIYLVFLLTFLLYNNARAEISDHLREDIPDLDMELSSASSAHLNGKELPAVPQNSVQTHPRRH 66

Human    54 --TPRPKVLRCKCH-------------HHC----------PEDSVNNICSTDGYCFTMIEEDDSG 93
              :.|....|.||:             |.|          ..|:...:..:.| |.|..::
  Fly    67 IKSKRRMKRRYKCYSCEPPCRDPYEFTHTCQNAIQCWKSRTRDADGQVQESRG-CSTSPDQ---- 126

Human    94 LPVVTS-GCLGLEGSDFQCRDTPIPHQRR-----SIECCTERNECNKDLHPTLPPLKNRDF---- 148
            ||::.| ..|.:.|          |.:|.     ::.||. .:.||:...|.|.|..:.|.
  Fly   127 LPMICSQNSLKING----------PSKRNTGKFVNVVCCA-GDYCNEGDFPELLPFDSNDVTVIT 180

Human   149 ------------VDGPIHHRALLISVTVCSLLLVLIILFCYFRYKRQETRPRYSIGLEQD-ETYI 200
                        |.||....|||.:||:             |..:|...:...:...:|| |.|:
  Fly   181 ADTSSISKMLVAVLGPFLVIALLGAVTI-------------FFIRRSHRKRLAASRTKQDPEAYL 232

Human   201 PPGE----------SLRDLIEQSQSSGSGSGLPLLVQRTIAKQIQMVKQIGKGRYGEVWMGKWRG 255
            ...|          :||:.::.|.:||||||||||||||:|||:.:::.||:|:|||||.|.|.|
  Fly   233 VNDELLRATSAGDSTLREYLQHSVTSGSGSGLPLLVQRTLAKQVTLIECIGRGKYGEVWRGHWHG 297

Human   256 EKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDY 320
            |.:|||:||:.:|.||.||||||.|:|:|||||||||.:|:....|.|||:|:|.|:..|||:|:
  Fly   298 ESIAVKIFFSRDEESWKRETEIYSTILLRHENILGFIGSDMTSRNSCTQLWLMTHYYPLGSLFDH 362

Human   321 LKSTTLDAKSMLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAV 385
            |....|....|:.:..|..:||.|||||||..|||||:||||||||||||..||:|.|||.||||
  Fly   363 LNRNALSHNDMVWICLSIANGLVHLHTEIFGKQGKPAMAHRDLKSKNILVTSNGSCVIADFGLAV 427

Human   386 KFISDTNEVDIPPNTRVGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIV 450
            .....|.::|:..|.:|||||||.|||||||::...|::....|:|:|||:||||.||.:|.||.
  Fly   428 THSHVTGQLDLGNNPKVGTKRYMAPEVLDESIDLECFEALRRTDIYAFGLVLWEVCRRTISCGIA 492

Human   451 EEYQLPYHDLVPSDPSYEDMREIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPASRLTAL 515
            |||::|::|:||.|||:||||::|||...|||.|||||||..:..|.|||.|||..||..||.||
  Fly   493 EEYKVPFYDVVPMDPSFEDMRKVVCIDNYRPSIPNRWSSDSLMTGMSKLMKECWHQNPDVRLPAL 557

Human   516 RVKKTLAKMSESQD 529
            |:|||:.|::.:.:
  Fly   558 RIKKTIHKLASADE 571

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
BMPR1B	NP_001243722.1	Activin_recp	60..140	CDD:279413	21/108 (19%)
		STKc_BMPR1b	228..532	CDD:271121	171/302 (57%)
		S_TKc	235..519	CDD:214567	162/283 (57%)
sax	NP_001246193.1	Activin_recp	77..168	CDD:279413	20/106 (19%)
		TM_EGFR-like	182..218	CDD:213052	10/48 (21%)
		TGF_beta_GS	247..274	CDD:285687	17/26 (65%)
		STKc_ACVR1_ALK1	270..567	CDD:271044	171/296 (58%)
		TyrKc	276..553	CDD:197581	157/276 (57%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D338017at33208
OrthoFinder	1	1.000	-	-		FOG0000203
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X151
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.820