DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment BMPR1B and tkv

DIOPT Version :9

Sequence 1:	NP_001243722.1	Gene:	BMPR1B / 658	HGNCID:	1077	Length:	532	Species:	Homo sapiens
Sequence 2:	NP_787990.1	Gene:	tkv / 33753	FlyBaseID:	FBgn0003716	Length:	575	Species:	Drosophila melanogaster

Alignment Length:	550	Identity:	269/550 - (48%)
Similarity:	347/550 - (63%)	Gaps:	45/550 - (8%)

- Green bases have known domain annotations that are detailed below.

Human    13 IFLLILLSMHTRANFLDNM--------------LLRSAGKLNVGTKKEDGESTAPTPRPKVLRCK 63
            :|..|.|...||:.|..|:              :...:|..:.|.:..|.|.:......:.|.|.
  Fly    20 LFEEIALEALTRSEFSANVQPDVEAMAAAALSGMEMGSGPGSEGYEDADNEKSKTVENARSLTCY 84

Human    64 CHHHCPEDSVNNICST--DGYCFTMIE---EDDSGL--PVVTSGCLGLE--GSDFQCRDTPIPH- 118
            |...||::..|..|.|  .|.||:.::   ::.:|:  ...|.||:..|  |....|:...:||
  Fly    85 CDGSCPDNVSNGTCETRPGGSCFSAVQQLYDETTGMYEEERTYGCMPPEDNGGFLMCKVAAVPHL 149

Human   119 QRRSIECCTERNECNKDLHPTLPPLKNRDFVDGPI-----HHRALLISVTVCSLLLVLIILFCYF 178
            ..::|.||.:.:.||:||:||..|.......|.|:     |..|:..|:.:...:.:||:....|
  Fly   150 HGKNIVCCDKEDFCNRDLYPTYTPKLTTPAPDLPVSSESLHTLAVFGSIIISLSVFMLIVASLCF 214

Human   179 RYKRQE---TRPRYSIGLEQDETYIPPGESLRDLIEQSQSSGSGSGLPLLVQRTIAKQIQMVKQI 240
            .|||:|   .:||....:...:  :.|   |..|:|  ||||||||||||||||||||||||:.:
  Fly   215 TYKRREKLRKQPRLINSMCNSQ--LSP---LSQLVE--QSSGSGSGLPLLVQRTIAKQIQMVRLV 272

Human   241 GKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQL 305
            |||||||||:.|||.|:||||.|||||||||||||||||||||||:||||||||||||.|||||:
  Fly   273 GKGRYGEVWLAKWRDERVAVKTFFTTEEASWFRETEIYQTVLMRHDNILGFIAADIKGNGSWTQM 337

Human   306 YLITDYHENGSLYDYLKSTTLDAKSMLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILV 370
            .|||||||.|||:|||..:.::.:.:..||:|..|||.|||.|||.|.|||||||||:|||||||
  Fly   338 LLITDYHEMGSLHDYLSMSVINPQKLQLLAFSLASGLAHLHDEIFGTPGKPAIAHRDIKSKNILV 402

Human   371 KKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGL 435
            |:||.|.|||.|||||:.|:.:.:.|..|.||||:|||.||||.:.|:...|:.:..|||||.||
  Fly   403 KRNGQCAIADFGLAVKYNSELDVIHIAQNPRVGTRRYMAPEVLSQQLDPKQFEEFKRADMYSVGL 467

Human   436 ILWEVARRC---VSG---GIVEEYQLPYHDLVPSDPSYEDMREIVCIKKLRPSFPNRWSSDECLR 494
            :|||:.|||   |||   ...|:|.|||||:|||||::|||..:||:|..||..|:||..|:.|.
  Fly   468 VLWEMTRRCYTPVSGTKTTTCEDYALPYHDVVPSDPTFEDMHAVVCVKGFRPPIPSRWQEDDVLA 532

Human   495 QMGKLMTECWAHNPASRLTALRVKKTLAKM 524
            .:.|:|.|||..||..|||||||||||.::
  Fly   533 TVSKIMQECWHPNPTVRLTALRVKKTLGRL 562

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BMPR1B	NP_001243722.1	Activin_recp	60..140	CDD:279413	28/89 (31%)
		STKc_BMPR1b	228..532	CDD:271121	196/302 (65%)
		S_TKc	235..519	CDD:214567	185/289 (64%)
tkv	NP_787990.1	Activin_recp	81..171	CDD:279413	28/89 (31%)
		GS	238..266	CDD:197743	23/32 (72%)
		S_TKc	267..557	CDD:214567	185/289 (64%)
		STKc_BMPR1	270..562	CDD:271046	186/291 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144593
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H20322
Inparanoid	1	1.050	490	1.000	Inparanoid score	I1427
Isobase	1	0.950	-	0	Normalized mean entropy	S3028
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D338017at33208
OrthoFinder	1	1.000	-	-		FOG0000203
OrthoInspector	1	1.000	-	-		oto91233
orthoMCL	1	0.900	-	-		OOG6_105740
Panther	1	1.100	-	-	O	PTHR23255
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2798
SonicParanoid	1	1.000	-	-		X151
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.740