DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLCO1A2 and Oatp58Da

DIOPT Version :9

Sequence 1:	NP_001373807.1	Gene:	SLCO1A2 / 6579	HGNCID:	10956	Length:	670	Species:	Homo sapiens
Sequence 2:	NP_611657.2	Gene:	Oatp58Da / 37543	FlyBaseID:	FBgn0050277	Length:	684	Species:	Drosophila melanogaster

Alignment Length:	678	Identity:	180/678 - (26%)
Similarity:	313/678 - (46%)	Gaps:	79/678 - (11%)

- Green bases have known domain annotations that are detailed below.

Human     2 GETEKRIETHRIRCLSKLKMFLLAITCAFVSKTLSGSYMNSMLTQIERQFNIPTSLVGFINGSFE 66
            |.:.:|..|..        |:::....|....|::.:|.|..:|.:|:::.|||.:.|.|:...:
  Fly    56 GPSMQRFATEH--------MYVILYGLAGCVMTMTFAYFNGTITTLEKRYKIPTKVSGIISVGND 112

Human    67 IGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGLGCFLKSLPHFLMNQYEYESTVSVSGNLSSNSFL 131
            |..:|....:.|:....|||..:|||.:.:...|.|.|..|||....|....::......:.:..
  Fly   113 ISTMLTAAILGYYAGHRHRPRWMGIGLLTIVAFCLLTSSLHFLYGAGEDALQLTREFGQVNETLT 177

Human   132 CMENGTQILRPTQDPSECTKEVKSLMW---VYVLVGNIVRGMGETPILPLGISYIEDFAKFENSP 193
            ..|...::.:||  ...|.:|...| |   |::....::.|:|:.....|||:|::|......:|
  Fly   178 NQERDKKLCQPT--AGGCVQEEVGL-WVPQVFLFAAQLISGVGQALFYTLGIAYMDDNTSKAKTP 239

Human   194 LYIGLVETGAIIGPLIGLLLASFCANVYVDTGFVNTDDLIITPTDTRWVGAWWFGFLICAGVNVL 258
            ..:.:.....::||.||..||:.|..:|::.    |.:.:|...|.||:||||.|:|:.|.:.::
  Fly   240 AMLSMSTFLRMLGPAIGYSLAAVCLRLYIEP----TLEPLIGQEDPRWLGAWWLGWLVLAAITLV 300

Human   259 TAIPFFFLPNTLP---KEGLETNADIIKNENEDKQKEEVKKEKYGITKDFLPFMKSLSCNPIYML 320
            :||..|..|..||   |..|:.        .:|::|:.:...:..:. |.:..:|.||.|.:|:.
  Fly   301 SAILLFMFPKQLPSARKRRLQL--------KQDERKQSLPLNERSLA-DMMKTVKKLSKNKVYVY 356

Human   321 FILVSVIQFNAFVNMISFMPKYLEQQYGISSSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVK 385
            ..:.|::.|..::....|.|||:|.||..|::.|....|...|.....|.:|.|.::.|:|.:.:
  Fly   357 NTMASILYFFGYMVYWIFTPKYIETQYRQSAAMATMATGTVALGFSAAGILISGYVISKYKPSAR 421

Human   386 QAAHIGCWLSLLEY-----LLYFLSFLMTCENSSVVGINTSYEGIPQDLYVENDIFADCNVDCNC 445
            ..|   .|.:::::     :|.:::  :.||.|..:...|:       |...|    .|:..|:|
  Fly   422 AMA---AWNAIVDFVTVAGILCYVA--IGCEGSDRLNTLTT-------LSAGN----SCSASCHC 470

Human   446 PSKIWDPVCGNNGLSYLSACLAGC--ETSIGTGINMVFQNCSCIQTSGNSS------AVLGLCDK 502
            ....:.|||..:.::::|||.|||  .|....| ..::..|.|:.:|..:|      ||.|.|.
  Fly   471 DYVHYAPVCSADNITFISACHAGCSERTKDALG-RTIYTGCECLGSSSLNSEPESQFAVDGTCP- 533

Human   503 GPDCSLMLQYFLILSAMSSFIYSLAA---IPGYMVLLRCMKSEEKSLGVGLHTFCTRVFAGIPAP 564
             .||   ...|||...:..|:..:.|   ....::.||||..:||:..:||.:....:...||:|
  Fly   534 -VDC---FNEFLIFLGVMCFLKLVGASSKSTNLLLALRCMPPDEKTFALGLGSMAASLLGFIPSP 594

Human   565 IYFGALMDSTCLHWGTLKCGESGACRIYDSTTFRYIYLGLPAALRGSSFVPALIILIL---LRKC 626
            |:||.|:|:.||.||. .|...|.|.:||:.:.||. |.|.||.  ..|:...:.:.:   .:..
  Fly   595 IFFGWLIDNYCLVWGK-TCSNKGNCWLYDTKSMRYA-LNLSAAF--FIFLGGFLNIAVWYHAKNL 655

Human   627 HLPGENASSGTELIETKVKGKENECKDI 654
            .:..|..||..:    .:|.||.|.|.|
  Fly   656 KIFDEEESSPKD----SLKNKEVEMKTI 679

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLCO1A2	NP_001373807.1	oat	1..625	CDD:273279	171/647 (26%)
Oatp58Da	NP_611657.2	OATP	67..626	CDD:281175	161/597 (27%)
		MFS	69..>425	CDD:119392	98/374 (26%)
		KAZAL_SLC21	462..514	CDD:238650	17/56 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1029129at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820