Protein Alignment SLC19A1 and CG14694

DIOPT Version :10

• Sequence 1: XP_011527998.1
• Gene: SLC19A1 / 6573
• HGNCID: 10937
• Length: 688
• Species: Homo sapiens
• Sequence 2: NP_650028.1
• Gene: CG14694 / 41307
• FlyBaseID: FBgn0037845
• Length: 446
• Species: Drosophila melanogaster
• Alignment Length: 456
• Identity: 139/456 - (30%)
• Similarity: 245/456 - (53%)
• Gaps: 52/456 - (11%)

Human   119 LRSWRHLVCYLCFYGFMAQIRPGESFITPYLLGPDKNFTREQVTNEITPVLSYSYLAVLVPVFLL 183
            :.||..:.|.||.:||:.::||.|.:....|:|...:.|:::|...:.||.:|||||:|:.|||:
  Fly     1 MESWLKISCLLCIFGFLRELRPSEPYHAEILMGEWYHVTQDEVNRSVYPVGTYSYLALLIFVFLI 65

Human   184 TDYLRYTPVLLLQGLSFVSVWLLLLLGHSVAHMQLMELFYSVTMAARIAYSSYIFSLVRPARYQR 248
            ||.|||.||::....:.:.:|..|:...:::.:|.:|:||....|..:||.|||::.|....|.|
  Fly    66 TDLLRYKPVIIANATTGICIWGTLIWTTTLSGLQAVEVFYGFYQAGEVAYYSYIYAKVDKQYYPR 130

Human   249 VAGYSRAAVLLGVFTSSVLGQLLVTVGRVSFSTLNYISLAFLTFSVVLALFLKRPKRSLFF-NRD 312
            |..::|||:.:|...:.:|.|:::.:..:::..|.||::.....:::.|.||.:.::||:| ||.
  Fly   131 VTSHTRAAMFVGKLVAGILAQMVIGMRWMNYKQLFYITVTSQVAALLWAFFLPKVEKSLYFHNRS 195

Human   313 D--RGRCETSASELERMNPGPGGKLGHALRVACGDSVLARMLRELGDSLRRPQLRL--------- 366
            :  .|..::....||:.:..|..:                   |.....:.|.|:|
  Fly   196 EAIEGGTKSDGGNLEKGSEQPSNE-------------------EASQEKKIPALQLLWSHFRSAY 241

Human   367 -------WSLWWVFNSAGYYLVVYYVHILWN--EVDPTTNSARVYNGAADAASTLLGAITSFAAG 422
                   ||||:..:.||:..:..|:.::|.  |.:||.    .:|||.|.|.|||.|:.:..||
  Fly   242 TNPLVIQWSLWYAISLAGFLQITTYMQVVWKSFENEPTI----AWNGAVDVALTLLSAVFALLAG 302

Human   423 FV---KIRWARWSKLLIAGVTATQAGLVFLLAHTRHPSSIWLCYAAFVLFRGSYQFLVPIATFQI 484
            :.   ::. .|.|.|.:|.::..:.|.|.|...|   ..|:|.|..:||:.|.:.|.:.:|:.::
  Fly   303 YFHAGRLN-TRSSLLSMALLSVLEGGCVLLSCWT---DDIYLSYLGYVLYGGLFAFTITVASSEL 363

Human   485 ASSLSKELCALVFGVNTFFATIVKTIITF-IVSDVRGLGLPVRKQFQLYSVYFLILSIIYFLGAM 548
            ||||.::..|||||.|||...:::.|:|| :||:...|.|.|.:||.:|:.||:::.|:|.:..:
  Fly   364 ASSLEEDSFALVFGFNTFVGLLLQCILTFVVVSEKANLNLNVFQQFSVYAFYFIVIGIVYSIAVI 428

Human   549 L 549
            |
  Fly   429 L 429

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC19A1	XP_011527998.1	rfc	98..603	CDD:129888	139/456 (30%)
CG14694	NP_650028.1	Folate_carrier	2..411	CDD:460318	133/435 (31%)