DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment BMPR1A and bmpr1a

DIOPT Version :9

Sequence 1:	NP_004320.2	Gene:	BMPR1A / 657	HGNCID:	1076	Length:	532	Species:	Homo sapiens
Sequence 2:	XP_012822321.2	Gene:	bmpr1a / 734017	XenbaseID:	XB-GENE-485616	Length:	527	Species:	Xenopus tropicalis

Alignment Length:	528	Identity:	424/528 - (80%)
Similarity:	465/528 - (88%)	Gaps:	6/528 - (1%)

- Green bases have known domain annotations that are detailed below.

Human     6 IYIRLLGAYLFIISRVQGQNLDSMLHGTGMKSDSDQKKSENGVTLAPEDTLPFLKCYCSGHCPDD 70
            ::|...||.|..| ..|||:|:.:.|.|||||:||.||.|||||||||||||||.|||||:||::
Frog     5 LFIACFGALLLAI-HGQGQDLNILPHRTGMKSNSDPKKQENGVTLAPEDTLPFLYCYCSGYCPEN 68

Human    71 AINNTCITNGHCFAIIEEDDQGETTLASGCMKYEGSDFQCKDSPKAQLRRTIECCRTNLCNQYLQ 135
            |:||||||||.|||:|||||.|:..|.|||||.|||||||||||||..|||||||||:.||:.||
Frog    69 AVNNTCITNGQCFAMIEEDDHGDIILTSGCMKMEGSDFQCKDSPKALSRRTIECCRTDFCNRDLQ 133

Human   136 PTLPPVVIGPFFDGSIRWLVLLISMAVCIIAMIIF-SSCFCYKHYCKSISSRRRYNRDLEQDEAF 199
            |||.|.:  |..:..:|::.|:||:.||:|.:..| ...:.|||  |..|.|..|||:|:.|:||
Frog   134 PTLSPKL--PDAEYGLRFIALIISLVVCVIIIAGFILIIWLYKH--KLHSQRMLYNRNLDPDDAF 194

Human   200 IPVGESLKDLIDQSQSSGSGSGLPLLVQRTIAKQIQMVRQVGKGRYGEVWMGKWRGEKVAVKVFF 264
            ||.|||||.|||.|||||||||||||||||||||||||||:||||||||||||||||||||||||
Frog   195 IPAGESLKALIDISQSSGSGSGLPLLVQRTIAKQIQMVRQIGKGRYGEVWMGKWRGEKVAVKVFF 259

Human   265 TTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDFLKCATLDTR 329
            |.||||||||||||||||||||||||||||||||||||||:||||:|||||||||||||.|||||
Frog   260 TAEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQMYLITEYHENGSLYDFLKCTTLDTR 324

Human   330 ALLKLAYSAACGLCHLHTEIYGTQGKPAIAHRDLKSKNILIKKNGSCCIADLGLAVKFNSDTNEV 394
            :|||||||||||||||||||||||||||||||||||||||||:|.:||||||||||||||||:||
Frog   325 SLLKLAYSAACGLCHLHTEIYGTQGKPAIAHRDLKSKNILIKENWTCCIADLGLAVKFNSDTHEV 389

Human   395 DVPLNTRVGTKRYMAPEVLDESLNKNHFQPYIMADIYSFGLIIWEMARRCITGGIVEEYQLPYYN 459
            |:|||||||||||||||||||||||||||.|||||||||.||||||.|||||||||||||||||:
Frog   390 DIPLNTRVGTKRYMAPEVLDESLNKNHFQAYIMADIYSFSLIIWEMTRRCITGGIVEEYQLPYYD 454

Human   460 MVPSDPSYEDMREVVCVKRLRPIVSNRWNSDECLRAVLKLMSECWAHNPASRLTALRIKKTLAKM 524
            |||:|||:||||:|||:|.|||.||||||||||||||||||:||||.||||||||||||||||||
Frog   455 MVPNDPSFEDMRDVVCMKCLRPTVSNRWNSDECLRAVLKLMAECWAQNPASRLTALRIKKTLAKM 519

Human   525 VESQDVKI 532
            ||||||||
Frog   520 VESQDVKI 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BMPR1A	NP_004320.2	Activin_recp	59..138	CDD:279413	59/78 (76%)
		Mediates specificity for BMP ligand. /evidence=ECO:0000269\|PubMed:22799562	107..109		1/1 (100%)
		STYKc	234..521	CDD:214568	263/286 (92%)
		STKc_BMPR1a	238..524	CDD:271122	262/285 (92%)
bmpr1a	XP_012822321.2	Activin_recp	57..132	CDD:366445	56/74 (76%)
bmpr1a	XP_012822321.2	STKc_BMPR1a	233..519	CDD:271122	262/285 (92%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	555	1.000	Domainoid score	I2901
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H20911
Inparanoid	1	1.050	858	1.000	Inparanoid score	I3981
NCBI	1	1.000	-	-
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D100898at32523
OrthoFinder	1	1.000	-	-		FOG0000203
OrthoInspector	1	1.000	-	-		oto158191
Panther	1	1.100	-	-	LDO	PTHR23255
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X151
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.160