DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment BMPR1A and bmpr1aa

DIOPT Version :9

Sequence 1:	NP_004320.2	Gene:	BMPR1A / 657	HGNCID:	1076	Length:	532	Species:	Homo sapiens
Sequence 2:	NP_571696.2	Gene:	bmpr1aa / 58145	ZFINID:	ZDB-GENE-000502-1	Length:	527	Species:	Danio rerio

Alignment Length:	530	Identity:	405/530 - (76%)
Similarity:	450/530 - (84%)	Gaps:	8/530 - (1%)

- Green bases have known domain annotations that are detailed below.

Human     4 LYIYIRLLGAYLFI-ISRVQGQNLDSMLHGTGMKSDSDQKKSENGVTLAPEDTLPFLKCYCSGHC 67
            |:|.:.|.|..|.: :....|||.|.:|.|||:|.||  ::..:..|:||||...||.|:|||||
Zfish     5 LFITVVLTGVCLLLTLCSGAGQNPDHVLQGTGVKLDS--RRPGDDSTIAPEDAARFLSCHCSGHC 67

Human    68 PDDAINNTCITNGHCFAIIEEDDQGETTLASGCMKYEGSDFQCKDSPKAQLRRTIECCRTNLCNQ 132
            ||||.||||.|||.||||||||:.|:..|:|||||||||.||||||..||.|||||||:.:.|||
Zfish    68 PDDAKNNTCETNGQCFAIIEEDENGDVILSSGCMKYEGSHFQCKDSQFAQTRRTIECCQFDFCNQ 132

Human   133 YLQPTLPPVVIGPFFDGSIRWLVLLISMAVCIIAMIIFSSCFCYKHYCKSISSRRRYNRDLEQDE 197
            .|:|.|||....|   ....||..|||:.||..|:|.. :..||..| |..:.|:||:|||||||
Zfish   133 DLKPELPPRDSEP---PDPHWLAFLISVTVCFCALICV-TVICYYRY-KWQTERQRYHRDLEQDE 192

Human   198 AFIPVGESLKDLIDQSQSSGSGSGLPLLVQRTIAKQIQMVRQVGKGRYGEVWMGKWRGEKVAVKV 262
            ||||.||||||||:|||:||||||||||||||||||||.||.:|||||||||:|:||||||||||
Zfish   193 AFIPAGESLKDLINQSQTSGSGSGLPLLVQRTIAKQIQTVRMIGKGRYGEVWLGRWRGEKVAVKV 257

Human   263 FFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDFLKCATLD 327
            |||.||||||||||||||||||||||||||||||.|||:.|||||||||||||||||:||..|||
Zfish   258 FFTREEASWFRETEIYQTVLMRHENILGFIAADINGTGASTQLYLITDYHENGSLYDYLKFTTLD 322

Human   328 TRALLKLAYSAACGLCHLHTEIYGTQGKPAIAHRDLKSKNILIKKNGSCCIADLGLAVKFNSDTN 392
            |:|||:||:||||||||||||||||||||||||||||||||||||||:|||||||||||||||||
Zfish   323 TQALLRLAFSAACGLCHLHTEIYGTQGKPAIAHRDLKSKNILIKKNGTCCIADLGLAVKFNSDTN 387

Human   393 EVDVPLNTRVGTKRYMAPEVLDESLNKNHFQPYIMADIYSFGLIIWEMARRCITGGIVEEYQLPY 457
            |||:||:||:||:||||||||||:|||||||.||||||||:||:||||||||:||||||||||||
Zfish   388 EVDLPLSTRMGTRRYMAPEVLDETLNKNHFQAYIMADIYSYGLVIWEMARRCVTGGIVEEYQLPY 452

Human   458 YNMVPSDPSYEDMREVVCVKRLRPIVSNRWNSDECLRAVLKLMSECWAHNPASRLTALRIKKTLA 522
            |.|||||||||||.||||||.|||.|||||||||||||:|||||||||||||||||.||:|||||
Zfish   453 YEMVPSDPSYEDMLEVVCVKGLRPTVSNRWNSDECLRAMLKLMSECWAHNPASRLTILRVKKTLA 517

Human   523 KMVESQDVKI 532
            |||||||:||
Zfish   518 KMVESQDIKI 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BMPR1A	NP_004320.2	Activin_recp	59..138	CDD:279413	57/78 (73%)
		Mediates specificity for BMP ligand. /evidence=ECO:0000269\|PubMed:22799562	107..109		0/1 (0%)
		STYKc	234..521	CDD:214568	254/286 (89%)
		STKc_BMPR1a	238..524	CDD:271122	254/285 (89%)
bmpr1aa	NP_571696.2	Activin_recp	59..134	CDD:307282	55/74 (74%)
		TGF_beta_GS	200..227	CDD:312125	24/26 (92%)
		PKc_like	233..519	CDD:328722	254/285 (89%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194332384
Domainoid	1	1.000	539	1.000	Domainoid score	I2256
eggNOG	1	0.900	-	-		E2759_KOG2052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	816	1.000	Inparanoid score	I3365
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG40057
OrthoDB	1	1.010	-	-		D170424at7742
OrthoFinder	1	1.000	-	-		FOG0000203
OrthoInspector	1	1.000	-	-		otm27752
orthoMCL	1	0.900	-	-		OOG6_105740
Panther	1	1.100	-	-	LDO	PTHR23255
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2798
SonicParanoid	1	1.000	-	-		X151
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	1	1.500	-	-
	17	17.340