Protein Alignment BMPR1A and tkv

DIOPT Version :10

• Sequence 1: NP_001393488.1
• Gene: BMPR1A / 657
• HGNCID: 1076
• Length: 557
• Species: Homo sapiens
• Sequence 2: NP_787990.1
• Gene: tkv / 33753
• FlyBaseID: FBgn0003716
• Length: 575
• Species: Drosophila melanogaster
• Alignment Length: 562
• Identity: 276/562 - (49%)
• Similarity: 344/562 - (61%)
• Gaps: 87/562 - (15%)

Human    26 LDSMLHGTGMKS----DSDQKKS---ENGVTLAPEDTLPFLKCYCSGHCPDDAINNTCIT--NGH 81
            |..|..|:|..|    |:|.:||   ||..:|.         |||.|.|||:..|.||.|  .|.
  Fly    50 LSGMEMGSGPGSEGYEDADNEKSKTVENARSLT---------CYCDGSCPDNVSNGTCETRPGGS 105

Human    82 CFAIIE---EDDQG--ETTLASGCMKYE--GSDFQCKDSPKAQLR-RTIECC-RTNLCNQYLQPT 137
            ||:.::   ::..|  |.....|||..|  |....||.:....|. :.|.|| :.:.||:.|.||
  Fly   106 CFSAVQQLYDETTGMYEEERTYGCMPPEDNGGFLMCKVAAVPHLHGKNIVCCDKEDFCNRDLYPT 170

Human   138 LPPVVIGPFFD--------------GSIRWLVLLISMAVCIIAMIIFSSCFCYKGHLLLRVIHIR 188
            ..|.:..|..|              |||     :||::|  ..:|:.|.||.||.         |
  Fly   171 YTPKLTTPAPDLPVSSESLHTLAVFGSI-----IISLSV--FMLIVASLCFTYKR---------R 219

Human   189 GQLESEGGVPVVLRHYCKSISSRRRYNRDLEQDEAFIPVGESLKDLIDQSQSSGSGSGLPLLVQR 253
            .:|..:   |.::...|.|..|                   .|..|::  |||||||||||||||
  Fly   220 EKLRKQ---PRLINSMCNSQLS-------------------PLSQLVE--QSSGSGSGLPLLVQR 260

Human   254 TIAKQIQMVRQVGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIA 318
            ||||||||||.||||||||||:.|||.|:||||.|||||||||||||||||||||||:|||||||
  Fly   261 TIAKQIQMVRLVGKGRYGEVWLAKWRDERVAVKTFFTTEEASWFRETEIYQTVLMRHDNILGFIA 325

Human   319 ADIKGTGSWTQLYLITDYHENGSLYDFLKCATLDTRALLKLAYSAACGLCHLHTEIYGTQGKPAI 383
            |||||.|||||:.|||||||.|||:|:|..:.::.:.|..||:|.|.||.|||.||:||.|||||
  Fly   326 ADIKGNGSWTQMLLITDYHEMGSLHDYLSMSVINPQKLQLLAFSLASGLAHLHDEIFGTPGKPAI 390

Human   384 AHRDLKSKNILIKKNGSCCIADLGLAVKFNSDTNEVDVPLNTRVGTKRYMAPEVLDESLNKNHFQ 448
            ||||:||||||:|:||.|.|||.|||||:||:.:.:.:..|.||||:||||||||.:.|:...|:
  Fly   391 AHRDIKSKNILVKRNGQCAIADFGLAVKYNSELDVIHIAQNPRVGTRRYMAPEVLSQQLDPKQFE 455

Human   449 PYIMADIYSFGLIIWEMARRCIT--GG----IVEEYQLPYYNMVPSDPSYEDMREVVCVKRLRPI 507
            .:..||:||.||::|||.|||.|  .|    ..|:|.|||:::|||||::|||..|||||..||.
  Fly   456 EFKRADMYSVGLVLWEMTRRCYTPVSGTKTTTCEDYALPYHDVVPSDPTFEDMHAVVCVKGFRPP 520

Human   508 VSNRWNSDECLRAVLKLMSECWAHNPASRLTALRIKKTLAKM 549
            :.:||..|:.|..|.|:|.|||..||..||||||:||||.::
  Fly   521 IPSRWQEDDVLATVSKIMQECWHPNPTVRLTALRVKKTLGRL 562

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
BMPR1A	NP_001393488.1	TFP_LU_ECD_BMPR1A	57..140	CDD:467132	32/93 (34%)
		TGF_beta_GS	230..257	CDD:462503	19/26 (73%)
		STKc_BMPR1a	263..549	CDD:271122	185/291 (64%)
tkv	NP_787990.1	TFP_LU_ECD_Tkv	81..169	CDD:467125	31/96 (32%)
		GS	238..266	CDD:197743	22/48 (46%)
		STKc_BMPR1	270..562	CDD:271046	185/291 (64%)