DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment BMPR1A and tkv

DIOPT Version :9

Sequence 1:	NP_004320.2	Gene:	BMPR1A / 657	HGNCID:	1076	Length:	532	Species:	Homo sapiens
Sequence 2:	NP_787990.1	Gene:	tkv / 33753	FlyBaseID:	FBgn0003716	Length:	575	Species:	Drosophila melanogaster

Alignment Length:	537	Identity:	273/537 - (50%)
Similarity:	338/537 - (62%)	Gaps:	62/537 - (11%)

- Green bases have known domain annotations that are detailed below.

Human    26 LDSMLHGTGMKS----DSDQKKS---ENGVTLAPEDTLPFLKCYCSGHCPDDAINNTCIT--NGH 81
            |..|..|:|..|    |:|.:||   ||..:|.         |||.|.|||:..|.||.|  .|.
  Fly    50 LSGMEMGSGPGSEGYEDADNEKSKTVENARSLT---------CYCDGSCPDNVSNGTCETRPGGS 105

Human    82 CFAIIE---EDDQG--ETTLASGCMKYE--GSDFQCKDSPKAQLR-RTIECC-RTNLCNQYLQPT 137
            ||:.::   ::..|  |.....|||..|  |....||.:....|. :.|.|| :.:.||:.|.||
  Fly   106 CFSAVQQLYDETTGMYEEERTYGCMPPEDNGGFLMCKVAAVPHLHGKNIVCCDKEDFCNRDLYPT 170

Human   138 LPPVVIGPFFD--------------GSIRWLVLLISMAVCIIAMIIFSSCFCYKHYCKSISSRRR 188
            ..|.:..|..|              |||     :||::|  ..:|:.|.||.||...|.....|.
  Fly   171 YTPKLTTPAPDLPVSSESLHTLAVFGSI-----IISLSV--FMLIVASLCFTYKRREKLRKQPRL 228

Human   189 YNRDLEQDEAFIPVGESLKDLIDQSQSSGSGSGLPLLVQRTIAKQIQMVRQVGKGRYGEVWMGKW 253
            .|.......:      .|..|::  |||||||||||||||||||||||||.||||||||||:.||
  Fly   229 INSMCNSQLS------PLSQLVE--QSSGSGSGLPLLVQRTIAKQIQMVRLVGKGRYGEVWLAKW 285

Human   254 RGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLY 318
            |.|:||||.|||||||||||||||||||||||:||||||||||||.|||||:.|||||||.|||:
  Fly   286 RDERVAVKTFFTTEEASWFRETEIYQTVLMRHDNILGFIAADIKGNGSWTQMLLITDYHEMGSLH 350

Human   319 DFLKCATLDTRALLKLAYSAACGLCHLHTEIYGTQGKPAIAHRDLKSKNILIKKNGSCCIADLGL 383
            |:|..:.::.:.|..||:|.|.||.|||.||:||.|||||||||:||||||:|:||.|.|||.||
  Fly   351 DYLSMSVINPQKLQLLAFSLASGLAHLHDEIFGTPGKPAIAHRDIKSKNILVKRNGQCAIADFGL 415

Human   384 AVKFNSDTNEVDVPLNTRVGTKRYMAPEVLDESLNKNHFQPYIMADIYSFGLIIWEMARRCIT-- 446
            |||:||:.:.:.:..|.||||:||||||||.:.|:...|:.:..||:||.||::|||.|||.|
  Fly   416 AVKYNSELDVIHIAQNPRVGTRRYMAPEVLSQQLDPKQFEEFKRADMYSVGLVLWEMTRRCYTPV 480

Human   447 GG----IVEEYQLPYYNMVPSDPSYEDMREVVCVKRLRPIVSNRWNSDECLRAVLKLMSECWAHN 507
            .|    ..|:|.|||:::|||||::|||..|||||..||.:.:||..|:.|..|.|:|.|||..|
  Fly   481 SGTKTTTCEDYALPYHDVVPSDPTFEDMHAVVCVKGFRPPIPSRWQEDDVLATVSKIMQECWHPN 545

Human   508 PASRLTALRIKKTLAKM 524
            |..||||||:||||.::
  Fly   546 PTVRLTALRVKKTLGRL 562

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BMPR1A	NP_004320.2	Activin_recp	59..138	CDD:279413	31/89 (35%)
		Mediates specificity for BMP ligand. /evidence=ECO:0000269\|PubMed:22799562	107..109		0/1 (0%)
		STYKc	234..521	CDD:214568	187/292 (64%)
		STKc_BMPR1a	238..524	CDD:271122	185/291 (64%)
tkv	NP_787990.1	Activin_recp	81..171	CDD:279413	32/98 (33%)
		GS	238..266	CDD:197743	21/35 (60%)
		S_TKc	267..557	CDD:214567	184/289 (64%)
		STKc_BMPR1	270..562	CDD:271046	185/291 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	490	1.000	Inparanoid score	I1427
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D338017at33208
OrthoFinder	1	1.000	-	-		FOG0000203
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_105740
Panther	1	1.100	-	-	LDO	PTHR23255
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2798
SonicParanoid	1	1.000	-	-		X151
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.900