Protein Alignment BMPR1A and Bmpr1a

DIOPT Version :10

• Sequence 1: NP_001393488.1
• Gene: BMPR1A / 657
• HGNCID: 1076
• Length: 557
• Species: Homo sapiens
• Sequence 2: NP_033888.2
• Gene: Bmpr1a / 12166
• MGIID: 1338938
• Length: 532
• Species: Mus musculus
• Alignment Length: 557
• Identity: 521/557 - (93%)
• Similarity: 524/557 - (94%)
• Gaps: 25/557 - (4%)

Human     1 MPQLYIYIRLLGAYLFIISRVQGQNLDSMLHGTGMKSDSDQKKSENGVTLAPEDTLPFLKCYCSG 65
            |.|||.|||||||.|||||.||||||||||||||||||.||||.|||||||||||||||||||||
Mouse     1 MTQLYTYIRLLGACLFIISHVQGQNLDSMLHGTGMKSDLDQKKPENGVTLAPEDTLPFLKCYCSG 65

Human    66 HCPDDAINNTCITNGHCFAIIEEDDQGETTLASGCMKYEGSDFQCKDSPKAQLRRTIECCRTNLC 130
            |||||||||||||||||||||||||||||||.|||||||||||||||||||||||||||||||||
Mouse    66 HCPDDAINNTCITNGHCFAIIEEDDQGETTLTSGCMKYEGSDFQCKDSPKAQLRRTIECCRTNLC 130

Human   131 NQYLQPTLPPVVIGPFFDGSIRWLVLLISMAVCIIAMIIFSSCFCYKGHLLLRVIHIRGQLESEG 195
            |||||||||||||||||||||||||:||||||||:||||||||||||
Mouse   131 NQYLQPTLPPVVIGPFFDGSIRWLVVLISMAVCIVAMIIFSSCFCYK------------------ 177

Human   196 GVPVVLRHYCKSISSRRRYNRDLEQDEAFIPVGESLKDLIDQSQSSGSGSGLPLLVQRTIAKQIQ 260
                   |||||||||.||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   178 -------HYCKSISSRGRYNRDLEQDEAFIPVGESLKDLIDQSQSSGSGSGLPLLVQRTIAKQIQ 235

Human   261 MVRQVGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTG 325
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   236 MVRQVGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTG 300

Human   326 SWTQLYLITDYHENGSLYDFLKCATLDTRALLKLAYSAACGLCHLHTEIYGTQGKPAIAHRDLKS 390
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   301 SWTQLYLITDYHENGSLYDFLKCATLDTRALLKLAYSAACGLCHLHTEIYGTQGKPAIAHRDLKS 365

Human   391 KNILIKKNGSCCIADLGLAVKFNSDTNEVDVPLNTRVGTKRYMAPEVLDESLNKNHFQPYIMADI 455
            ||||||||||||||||||||||||||||||:||||||||||||||||||||||||||||||||||
Mouse   366 KNILIKKNGSCCIADLGLAVKFNSDTNEVDIPLNTRVGTKRYMAPEVLDESLNKNHFQPYIMADI 430

Human   456 YSFGLIIWEMARRCITGGIVEEYQLPYYNMVPSDPSYEDMREVVCVKRLRPIVSNRWNSDECLRA 520
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   431 YSFGLIIWEMARRCITGGIVEEYQLPYYNMVPSDPSYEDMREVVCVKRLRPIVSNRWNSDECLRA 495

Human   521 VLKLMSECWAHNPASRLTALRIKKTLAKMVESQDVKI 557
            |||||||||||||||||||||||||||||||||||||
Mouse   496 VLKLMSECWAHNPASRLTALRIKKTLAKMVESQDVKI 532

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
BMPR1A	NP_001393488.1	TFP_LU_ECD_BMPR1A	57..140	CDD:467132	81/82 (99%)
		TGF_beta_GS	230..257	CDD:462503	26/26 (100%)
		STKc_BMPR1a	263..549	CDD:271122	284/285 (100%)
Bmpr1a	NP_033888.2	TFP_LU_ECD_BMPR1A	57..140	CDD:467132	81/82 (99%)
		Mediates specificity for BMP ligand. /evidence=ECO:0000250	107..109		1/1 (100%)
		TGF_beta_GS	205..232	CDD:462503	26/26 (100%)
		STKc_BMPR1a	238..524	CDD:271122	284/285 (100%)