DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC16A2 and CG8389

DIOPT Version :9

Sequence 1:	NP_006508.2	Gene:	SLC16A2 / 6567	HGNCID:	10923	Length:	539	Species:	Homo sapiens
Sequence 2:	NP_611076.2	Gene:	CG8389 / 36764	FlyBaseID:	FBgn0034063	Length:	471	Species:	Drosophila melanogaster

Alignment Length:	488	Identity:	103/488 - (21%)
Similarity:	177/488 - (36%)	Gaps:	106/488 - (21%)

- Green bases have known domain annotations that are detailed below.

Human    95 PEGGFGWVVVFAATWCNGSIFGIHNSVGILYSMLLEEEKEKNRQVEFQAAWV---GALAMGMI-F 155
            |:||:||:||.|....|.:    :.|:..::..|...|.:|.::..|.||.:   .:||:... .
  Fly    10 PDGGYGWIVVAAVALINMT----NQSILSVFGQLFVGELQKMQEDTFTAALITNLNSLALNFSGL 70

Human   156 FCSPIVSIFTDRLGCRITATAGAAVAFIGLHTSSFTSSLSLRYFTYGILFGCGCSFAFQPSLVIL 220
            |..|.:..|..|   .:.|| |..:..:||...:|.|........|....|.|.......:.:.:
  Fly    71 FIGPAIKSFKPR---NVAAT-GCILVALGLALCAFASESWHFILGYSFFVGFGLGLISPSTFMAI 131

Human   221 GHYFQRRLGLANGVVSAGSSIFSMSFPFLIRMLGDKIKLAQTFQVLSTFMFVLMLLSL----TYR 281
            ..||..:.|.|.||..||:.:..:..|.|:|.|.|....  .:.|||  |..|.|..|    ..:
  Fly   132 NSYFTTKRGRAVGVSLAGAGLGQVLIPHLVRYLLDNHGF--RYAVLS--MSSLSLFGLFGAAFLK 192

Human   282 PLLPSSQDTPSKR--------------------------------GVRTLHQRFLAQLRKYFNMR 314
            ||.|.::....|.                                .|.||..|...:|.:..::.
  Fly   193 PLNPPAKHNNRKHIRLLTEADGEKTSPLQVVIVPTNQSKIERSPPNVDTLCSRMGQRLVQAMDLE 257

Human   315 VFRQRTYRIWAFGIAAAALGYFVPYVHLMKYVEEEFSEIKETWVLLVCIGATSGLGRLVSGHISD 379
            :.:...:  |:. |...||.|              .:.|..|.:....:|.|:.|...:......
  Fly   258 LLKDLVF--WSI-IVGMALVY--------------TATINFTMIFPGFLGQTAQLNSQMVAFCMS 305

Human   380 SIPGLKKIYLQVLSFL------------LLGLMSMMIPLC-----RDFGGLIVVCLFLGLCDGFF 427
            .:.|...::..:|..:            |:|::.:.:..|     :....:|.:.:..|:.....
  Fly   306 LVAGADIVFRLLLPIVTDHLRIPYRVVFLIGIVGLFVARCVLAENQTLPVIITMSVLTGMMKSAT 370

Human   428 I-----TIMAPIAFE-LVGPMQASQAIGYLLGMMA--LPMIAGPPIAGLLRNCFGDYHVAFYFAG 484
            :     ||.|....| |.|        |..|.||:  :.:|....:.|.:|:....|.:..|..|
  Fly   371 VINNNLTISAHCRSEKLAG--------GLGLSMMSKGVIVITVGQLLGWVRDYADSYLICLYAQG 427

Human   485 VPPIIGAVILFFVPLMHQRMFKKEQRDSSKDKM 517
            |  |:..|:|.:.|.:..|  .:.||.::...|
  Fly   428 V--ILLVVVLVWTPEILYR--HRRQRCATNKSM 456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC16A2	NP_006508.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..92
		2A0113	86..513	CDD:273325	102/482 (21%)
		MFS	101..498	CDD:119392	94/461 (20%)
		DUF1564	<286..>334	CDD:284922	9/79 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	508..539		3/10 (30%)
CG8389	NP_611076.2	MFS	19..425	CDD:119392	86/442 (19%)
CG8389	NP_611076.2	MFS_1	19..400	CDD:284993	82/417 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2504
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.861654	Normalized mean entropy	S4246
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D916876at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.770