DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC16A2 and Sln

DIOPT Version :9

Sequence 1:	NP_006508.2	Gene:	SLC16A2 / 6567	HGNCID:	10923	Length:	539	Species:	Homo sapiens
Sequence 2:	NP_610706.1	Gene:	Sln / 36263	FlyBaseID:	FBgn0033657	Length:	855	Species:	Drosophila melanogaster

Alignment Length:	661	Identity:	122/661 - (18%)
Similarity:	216/661 - (32%)	Gaps:	224/661 - (33%)

- Green bases have known domain annotations that are detailed below.

Human    71 SERVHEPEPTPTVETRGTARGFQPPEGGFGWVVVFAATWCNGSIFGIHNSVGILYSMLLEEEKEK 135
            |::|.:...:.|..|.......:||:||:||.:||.|......:.|:..|.|:||..::|.....
  Fly   202 SKQVVKDRDSSTTTTESGGPNVEPPDGGYGWFIVFGAFSVQFWVAGLVKSYGVLYVEIMETFPSS 266

Human   136 NRQVEFQAAWVGALAMGMIFFCSPIVSIFTDRLGCRITATAGAAVAFIGLHTSSFTSSLSLRYFT 200
            ...|   |:|:.|:...:....:|:.|....|..||.....|.....:|:..|.|.:||.....|
  Fly   267 TATV---ASWIPAILSALCLVLAPLSSALCQRFSCRTVVFVGGIFCAMGMILSYFATSLLHLLLT 328

Human   201 YGILFGCGCSFAFQPSLVILGHYFQRRLGLANGVVSAGSSIFSMSFPFLIRMLGDKIKLAQTFQV 265
            :|:|.|.|...:..|.:||:..||.:...||||:..:|::..|...|.||:.|.:......|..:
  Fly   329 FGVLTGIGGGLSTTPGIVIVSQYFDKHRALANGICVSGTAAGSFILPVLIKHLAENCGFHGTILI 393

Human   266 LSTFMFVLMLLSLTYRPL----------------LPSSQD-TPSKRGVRT--------------- 298
            |...|..:.:.:..|||:                .|.::| .||..|:.|
  Fly   394 LGGCMLHVCVSATLYRPISAYTDQDSGQGQEETAKPLNEDINPSTTGILTTSTYLDTCDVGAGHE 458

Human   299 -----LHQRFLAQLRKYFNMRVFRQ---------------------------------------- 318
                 :...||.:.:.:.|....:|
  Fly   459 LSDKFIEHLFLEESKNHLNYYASKQPAQDKSAQESDDEVKDIIGETTFIKPMKKVRSSGLLHSVE 523

Human   319 --RTYRIWAF------------------------------------------------------- 326
              .|...|.:
  Fly   524 DLSTDSTWVYRKHSGTDSNRGSRRRRNVFANDEVISKIQAHLEKPLSPPSVVSRGLSKSMEIPTP 588

Human   327 ----------GIAAAALGYFVPYV---------HLMKYVEEEFSE-------------------I 353
                      .:..|.||.....:         ||....:::..|                   :
  Fly   589 VSNLSDLKQQPVEQAELGILDSQLVESIIDGDGHLAADEDDDDDEERGPRTCCERIEMYLDISLL 653

Human   354 KETWVLLVCIGAT--------------------------SG-----------LGRLVSGHISD-S 380
            ::...:|:|:..|                          :|           :|||..|.:.| .
  Fly   654 QDPSFILMCLSVTLMSVGCPYMLYYLPAHVISIGYNKSEAGYLVAISAVLDLIGRLGLGWLCDLQ 718

Human   381 IPGLKKIYLQVLSFLLLGLMSMMIPLCRDFGGLIVVCL---FLGLCDGFFITIMAPIAFELVGPM 442
            :...||.|  .|..|..|...:.||..:.   |::|.|   ..|||.|.:..:|..:..::.|..
  Fly   719 LFDRKKTY--TLCILGAGCAVLTIPFAKT---LVLVGLSAAVYGLCLGSWYVLMPVLLADVFGTD 778

Human   443 QASQAIGYLLGMMALPMIAGPPIAGLLRNCFGDYHVAFYFAGVPPIIGA---VILFFVPLMHQRM 504
            :.|.:.|.:....::..|:.||:|||:|:..|||.:.||..|...::|.   ::...:...:.|:
  Fly   779 RISSSYGLVRMFQSIGAISVPPLAGLMRDLSGDYEICFYCMGSCMVLGTTPLIVWSILEARNHRL 843

Human   505 FKKEQRDSSKD 515
            |.:.:.:..::
  Fly   844 FVQREEEECEE 854

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC16A2	NP_006508.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..92		4/20 (20%)
		2A0113	86..513	CDD:273325	118/642 (18%)
		MFS	101..498	CDD:119392	111/612 (18%)
		DUF1564	<286..>334	CDD:284922	12/175 (7%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	508..539		0/8 (0%)
Sln	NP_610706.1	MFS	235..>411	CDD:119392	49/178 (28%)
		MFS	<656..827	CDD:119392	41/175 (23%)
		MFS_1	658..>847	CDD:284993	44/193 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145581
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2504
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D916876at2759
OrthoFinder	1	1.000	-	-		FOG0000033
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.750