DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC16A2 and chk

DIOPT Version :9

Sequence 1:	NP_006508.2	Gene:	SLC16A2 / 6567	HGNCID:	10923	Length:	539	Species:	Homo sapiens
Sequence 2:	NP_001163063.1	Gene:	chk / 35578	FlyBaseID:	FBgn0033095	Length:	894	Species:	Drosophila melanogaster

Alignment Length:	763	Identity:	115/763 - (15%)
Similarity:	210/763 - (27%)	Gaps:	354/763 - (46%)

- Green bases have known domain annotations that are detailed below.

Human    95 PEGGFGWVVVFAATWCNGSIFGIHNSVGILYSMLLEEEKEKNRQVEFQAAWVGALAMGMIFFCSP 159
            |:||:|||||||:...:....|:..|.|::...|||...|...    :.||:.:|...:.....|
  Fly   133 PDGGYGWVVVFASLVVSLIADGLSFSFGLINVELLEYFGESTS----KTAWISSLFFSVPLLMGP 193

Human   160 IVSIFTDRLGCRITATAGAAVAFIGLHTSSFTSSLSLRYFTYGILFGCGCSFAFQPSLVILGHYF 224
            |.|...|:.|||.....|..|:..|...|||.:|:.:...|:||:.|.|....:..::|.:..:|
  Fly   194 IWSNLVDKYGCRKMTILGGVVSAFGFALSSFCNSIEMLMVTFGIISGLGLGIGYVTAVVSIAFWF 258

Human   225 QRRLGLANGVVSAGSSI----FSMSFPFLIRMLG-----------------------------DK 256
            .::...|.|:.::|:.|    ::....:||...|                             ::
  Fly   259 DKKRTFATGIGASGTGIGTFVYARLTSYLIESYGWRGATLILGGTMLNACVCGALMRDPDWLIEE 323

Human   257 IKLAQTFQVLSTF---------------------------------------------------- 269
            .:|....|.::||
  Fly   324 NRLESRSQSVTTFSNSSVCLEEIKKLLDTGITKEAVLDSLVTKNNTEANQQIDDPLDSALKRYRS 388

Human   270 -MFVLMLLSL---------------------------------------TYRP---LLPSSQDT- 290
             :|:...||.                                       .|.|   ::.|..||
  Fly   389 EIFLPTFLSTQELDSICEVKSLSRRSLRHKEGEEAPSRENLLSMSSGAGAYPPSTAVIGSPDDTL 453

Human   291 ----------------------------------------------------------------- 290

  Fly   454 MGGIAHEAAEEAKKAYLASIETLSPSEKRSTGRTPNGSLRSSDEGYLTQKHASSRYSLNENIFMA 518

Human   291 -----------------------------------------PSKR-------------------- 294
                                                     ||:|
  Fly   519 KHTTPSISNLKVNGLRHNSVDILSEDMHCYYSKDETFALLEPSRRIRPTVIAIPEQEQSVNSELA 583

Human   295 ----------GVRTL-------HQR---------------------------------------- 302
                      |:|.|       |.|
  Fly   584 TRRARLDSITGIRRLSRSKKPSHHRSNLRRNISIRNSNFLKDMRIHRNSIHYRGAMLNTHRYRLR 648

Human   303 --------------------------FLAQLRKYFNMRVFRQRTYRIWAFGIAAAALGYFVPYVH 341
                                      |:..::..|:..:|....:.::........:.:.:||::
  Fly   649 ASSCPNIYRNSMTTIAKEEEDTWYDNFVDTMKSIFDFSLFLDMKFALFNLSTLFLFIWFIIPYLY 713

Human   342 LMKYVEEEFSEIKETWVLLVCIGATSGLGRLVSGHISDSIPGLKKIYLQV---LSFLLLGLMSMM 403
            |..|:::...::.::..|:..:|....:|.:..|::.|    |..:.:.:   |..|:.|.....
  Fly   714 LPDYMKQYKYDVSQSAELISDVGIAQTVGMIGLGYLGD----LSWMNINICYSLCMLVCGASVFF 774

Human   404 IP-LCRDFGGLIVVCLFLGLCDGFFITIMAPIAFELVGPMQASQAIGYLLGMMALPMIAGPPIAG 467
            :| |..::.||:|:|:..|.......:....|...:|.....:.|.|.:|.:..:.|||||||||
  Fly   775 MPLLITNYMGLMVMCVIFGFTFASSFSFTPSILVSIVDLDDFTCAYGLVLLVQGVGMIAGPPIAG 839

Human   468 LLRNCFGDYHVAFYFAGVPPIIGAVILFFVPLMHQRMFKKEQRDSSKD 515
            ::....|.:...||:||:...:..|..:.:....    ||..::|..|
  Fly   840 VIYEYTGRWDDTFYYAGIFIALSGVCSYLIEFCE----KKAPKESDSD 883

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC16A2	NP_006508.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..92
		2A0113	86..513	CDD:273325	113/759 (15%)
		MFS	101..498	CDD:119392	107/738 (14%)
		DUF1564	<286..>334	CDD:284922	14/257 (5%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	508..539		2/8 (25%)
chk	NP_001163063.1	MFS	143..>315	CDD:119392	40/175 (23%)
chk	NP_001163063.1	MFS	<685..869	CDD:119392	41/187 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2504
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000033
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810