Protein Alignment SLC16A2 and Mct1

DIOPT Version :9

• Sequence 1: NP_006508.2
• Gene: SLC16A2 / 6567
• HGNCID: 10923
• Length: 539
• Species: Homo sapiens
• Sequence 2: NP_001284810.1
• Gene: Mct1 / 31198
• FlyBaseID: FBgn0023549
• Length: 626
• Species: Drosophila melanogaster
• Alignment Length: 628
• Identity: 122/628 - (19%)
• Similarity: 209/628 - (33%)
• Gaps: 198/628 - (31%)

Human    65 PELEFESERVHEP-----EPTPTVETRGTARGFQPPEGGFGWVVVFAATWCNGSIFGIHNSVGIL 124
            |....:|::.||.     |..||           ||:||:||||||.:...:....|:..|.||.
  Fly     5 PPARRKSQQQHEACEMDMERQPT-----------PPDGGWGWVVVFGSFMIHIVTDGMTYSFGIF 58

Human   125 YSMLLEEEKEKNRQVEFQAAWVGALAMGMIFFCSPIVSIFTDRLGCRITATAGAAVAFIGLHTSS 189
            |:..|:...|.    :...||:.::.:|:.|...||.|.|.:|.|||....||:.:|...:..|.
  Fly    59 YNEFLDYFNEG----KGYTAWIASIMVGVTFSSGPISSSFVNRYGCRAVTIAGSILAASCIIVSM 119

Human   190 FTSSLSLRYFTYGILFGCGCSFAFQPSLVILGHYFQRRLGLANGVVSAGSSIFSMSFPFLIRMLG 254
            |..::.....|.|...|.|....:.|::|.:..||:.:..||.|:...||...:..|..|...|.
  Fly   120 FAQNVLTLIITIGFGTGLGFGLIYLPAIVSVTQYFEAKRSLATGIAVCGSGFGTFVFAPLTEFLI 184

Human   255 DKIKLAQTFQVLSTFMFVLMLLSLTYRPL------------------------------------ 283
            ..........::...:...::....:|||
  Fly   185 GNYGWRGAMLIIGGIVLNCIIFGAMFRPLELEAPPQTPPNTPSTPKLAKKSAIIDQNTTAAELEP 249

Human   284 -----------LPSSQD--------------------------------------TPSKRGVRT- 298
                       ||...|                                      ||.:..|::
  Fly   250 LKVLPKDQYLQLPQRTDTAVSGGALCRSNSVGHNLKPNLNNNSNGAVNGQGPTLVTPPQAVVKST 314

Human   299 ------------------------------------LHQRFLAQLRKY----------------- 310
                                                |:|..|..|..|
  Fly   315 SNDDIARKCHSQLQLTPLRDAHRERSASGTMYRPDALYQGSLHNLPDYVSSRNDLSRSMSGSGVI 379

Human   311 --------------------------------------FNMRVFRQRTYRIWAFGIAAAALGYFV 337
                                                  .|..:.:...:.|::......::|:.|
  Fly   380 KRYGSLRQSNNVSQSQEEAKCCGCITCSKETRDTFAEMMNFSLLKDMVFVIFSVSNFCTSIGFNV 444

Human   338 PYVHLMKYVEEEFSEIKETWVLLVCIGATSGLGRLVSGHISDSIPGLKKIYLQVLSFLLLGLMSM 402
            ||::::.|.|.......:...|:..||..:.:||::.|:|||. |.:.::.:..:.....|:.:.
  Fly   445 PYLYVVAYAETLKLTKTDASYLISTIGVANTVGRIILGYISDK-PWVNRLLVYNVCLTACGVSTA 508

Human   403 MIPLCRDFGGLIVVCLFLGLCDGFFITIMAPIAFELVGPMQASQAIGYLLGMMALPMIAGPPIAG 467
            |:|||.||..|...|...|...|.::.:.:.|..:|:|..:.:.|.|.||....:....||||.|
  Fly   509 MVPLCHDFQSLAFYCCVFGFTIGAYVGLTSVILVDLLGLDKLTNAFGLLLLFQGIASFIGPPIGG 573

Human   468 LLRNCFGDYHVAFYFAGVPPIIGAVILFFVPLMHQRMFKKEQR 510
            .:.:....|..||..||:...|..:::|.:|.:.:...:|.:|
  Fly   574 WMYDLTDSYAPAFLMAGLMIAISGLVMFAIPPLQRLQVRKSER 616

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC16A2	NP_006508.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..92		7/31 (23%)
		2A0113	86..513	CDD:273325	115/602 (19%)
		MFS	101..498	CDD:119392	107/573 (19%)
		DUF1564	<286..>334	CDD:284922	11/177 (6%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	508..539		1/3 (33%)
Mct1	NP_001284810.1	MFS	35..>213	CDD:119392	46/181 (25%)
		MFS	<426..604	CDD:119392	47/178 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145567
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2504
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D916876at2759
OrthoFinder	1	1.000	-	-		FOG0000033
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.750