Protein Alignment SLC16A1 and CG8468

DIOPT Version :10

• Sequence 1: NP_003042.3
• Gene: SLC16A1 / 6566
• HGNCID: 10922
• Length: 500
• Species: Homo sapiens
• Sequence 2: NP_610940.1
• Gene: CG8468 / 36577
• FlyBaseID: FBgn0033913
• Length: 678
• Species: Drosophila melanogaster
• Alignment Length: 631
• Identity: 121/631 - (19%)
• Similarity: 206/631 - (32%)
• Gaps: 222/631 - (35%)

Human    13 PPDGGWGWAVVIGAFISIGFSYAFPKSITVFFKEIEGI--------------FHATTSEVSWISS 63
            |||.||.|.|::.:|:          ..||    |:||              |..:.:.|:::||
  Fly    43 PPDSGWAWVVMVASFL----------CCTV----IDGIVFCSGLIQEQLMAEFGVSKAYVAFVSS 93

Human    64 IMLAVMYGGGPISSILVNKYGSRIVMIVGGCLSGCGLIAASFCNTVQQLYVCIGVIGGLGLAFNL 128
            ::.......||..|.:.|::|.|.|.|.|...:......:.|..:|:.|::..||:||:|.....
  Fly    94 LLSGCYLMAGPFVSAMANRFGFRPVTITGAIFAAICFGLSYFATSVEYLFLIYGVLGGIGFCMVY 158

Human   129 NPALTMIGKYFYKRRPLANGLAMAGSPVFLCTLAPLNQVFFGIFGWRGSFLILGGLLLNCCVAGA 193
            .||:.:||.||.|.|.||.|:||.||.|.....|||.::... .|||.:..|.|.::|:|.:.|.
  Fly   159 IPAVVIIGFYFEKWRALATGVAMCGSGVGTFVFAPLTKILLK-SGWRYTLAIQGIIVLSCALFGL 222

Human   194 LMRPIGP---------------------------------------------------------- 200
            ..|||.|
  Fly   223 AFRPIQPITLSVTNEEGDEQEKKKLNGHGNTVAPTPQLHQAAFTKPLPEGRFAYSMPNSAHNTYM 287

Human   201 ----------------------KPTKAGKDKSKASLEKAGKS--------------GVKKDL--- 226
                                  :|:...:......|::..||              .:.|:|
  Fly   288 GASQRNHYPTAQEIFKGMNLERRPSGTAQGSKGTELKQLRKSQPTTPNGDPQQLTFNLHKELTTV 352

Human   227 ----HDANTD------------------LIGRHPKQ-EKRS------------------------ 244
                .:|..|                  :.||.|:. .|||
  Fly   353 GENEEEAENDNLLETEAKPVTIQARRHTVSGRRPQDIGKRSAAAAHEAHHGQSHSSSRPMYRDDI 417

Human   245 -----------------------------------------------VFQTINQFLDLTLFTHRG 262
                                                           |.:|::..||.||.....
  Fly   418 FFSGSLTRIPQYQSQTSLAYHMSVTRLPTKQDMLEDRQKGCRICPEAVRRTLSTMLDTTLLKSPA 482

Human   263 FLLYLSGNVIMFFGLFAPLVFLSSYGKSQHYSSEKSAFLLSILAFVDMVARPSMGLVANTKPIRP 327
            |:.......:...|.|.|..||....|:.....:.:..:||.:..|:..||...|.:::...::|
  Fly   483 FMCLAFSGFLTMMGFFVPFTFLVDRAKAAGMDEQAAYGVLSGIGVVNTFARIVCGSLSSFPAVKP 547

Human   328 RIQYFFAASVVANGVCHMLAPLSTTYVGFCVYAGFFGFAFGWLSSVLFETLMDLVGPQRFSSAVG 392
            .....||  :.|.|:..:.:.:.........:|.|||......|::.....::|:|.::.::|.|
  Fly   548 LWLNNFA--LTAGGIATICSGIVINTATQWTFALFFGICIACFSALRSLIAVELIGLEKLTNAYG 610

Human   393 LVTIVECCPVLLGPPLLGRLNDMYGDYKYTYWACGVVLIISGIYLF 438
            .:.:.:......|.|:.|.|..|.|.|...::..|.::::|....:
  Fly   611 FLMLFQGLAATFGSPIAGGLYVMTGSYNAAFYFAGGLILLSAFLCY 656

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC16A1	NP_003042.3	2A0113	1..455	CDD:273325	121/631 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	454..500
CG8468	NP_610940.1	MFS_MCT_SLC16	49..>225	CDD:340910	56/190 (29%)
		MFS	<477..658	CDD:475125	37/182 (20%)