Protein Alignment SLC16A1 and Mct1

DIOPT Version :9

• Sequence 1: NP_001159968.1
• Gene: SLC16A1 / 6566
• HGNCID: 10922
• Length: 500
• Species: Homo sapiens
• Sequence 2: NP_001284810.1
• Gene: Mct1 / 31198
• FlyBaseID: FBgn0023549
• Length: 626
• Species: Drosophila melanogaster
• Alignment Length: 608
• Identity: 142/608 - (23%)
• Similarity: 236/608 - (38%)
• Gaps: 174/608 - (28%)

Human    12 TPPDGGWGWAVVIGAF----ISIGFSYAFPKSITVFFKEIEGIFHATTSEVSWISSIMLAVMYGG 72
            |||||||||.||.|:|    ::.|.:|:|    .:|:.|....|:......:||:|||:.|.:..
  Fly    27 TPPDGGWGWVVVFGSFMIHIVTDGMTYSF----GIFYNEFLDYFNEGKGYTAWIASIMVGVTFSS 87

Human    73 GPISSILVNKYGSRIVMIVGGCLSGCGLIAASFCNTVQQLYVCIGVIGGLGLAFNLNPALTMIGK 137
            |||||..||:||.|.|.|.|..|:...:|.:.|...|..|.:.||...|||......||:..:.:
  Fly    88 GPISSSFVNRYGCRAVTIAGSILAASCIIVSMFAQNVLTLIITIGFGTGLGFGLIYLPAIVSVTQ 152

Human   138 YFYKRRPLANGLAMAGSPVFLCTLAPLNQVFFGIFGWRGSFLILGGLLLNCCVAGALMRPI---- 198
            ||..:|.||.|:|:.||.......|||.:...|.:||||:.||:||::|||.:.||:.||:
  Fly   153 YFEAKRSLATGIAVCGSGFGTFVFAPLTEFLIGNYGWRGAMLIIGGIVLNCIIFGAMFRPLELEA 217

Human   199 -------GPKPTKAGK-----DKSKASLEKAGKSGVKKD-------------------------- 225
                   .|...|..|     |::..:.|......:.||
  Fly   218 PPQTPPNTPSTPKLAKKSAIIDQNTTAAELEPLKVLPKDQYLQLPQRTDTAVSGGALCRSNSVGH 282

Human   226 -------------------------------------------------LHDANTD--------- 232
                                                             |.||:.:
  Fly   283 NLKPNLNNNSNGAVNGQGPTLVTPPQAVVKSTSNDDIARKCHSQLQLTPLRDAHRERSASGTMYR 347

Human   233 ------------------------------LIGRH----------PKQEK----------RSVFQ 247
                                          :|.|:          ..||:          :....
  Fly   348 PDALYQGSLHNLPDYVSSRNDLSRSMSGSGVIKRYGSLRQSNNVSQSQEEAKCCGCITCSKETRD 412

Human   248 TINQFLDLTLFTHRGFLLYLSGNVIMFFGLFAPLVFLSSYGKSQHYSSEKSAFLLSILAFVDMVA 312
            |..:.::.:|.....|:::...|.....|...|.:::.:|.::...:...:::|:|.:...:.|.
  Fly   413 TFAEMMNFSLLKDMVFVIFSVSNFCTSIGFNVPYLYVVAYAETLKLTKTDASYLISTIGVANTVG 477

Human   313 RPSMGLVANTKPIRPRIQYFFAASVVANGVCHMLAPLSTTYVGFCVYAGFFGFAFG---WLSSVL 374
            |..:|.::: ||...|: ..:...:.|.||...:.||...:.....|...|||..|   .|:||:
  Fly   478 RIILGYISD-KPWVNRL-LVYNVCLTACGVSTAMVPLCHDFQSLAFYCCVFGFTIGAYVGLTSVI 540

Human   375 FETLMDLVGPQRFSSAVGLVTIVECCPVLLGPPLLGRLNDMYGDYKYTYWACGVVLIISGIYLFI 439
               |:||:|..:.::|.||:.:.:.....:|||:.|.:.|:...|...:...|:::.|||:.:|
  Fly   541 ---LVDLLGLDKLTNAFGLLLLFQGIASFIGPPIGGWMYDLTDSYAPAFLMAGLMIAISGLVMF- 601

Human   440 GMGINYRLLAKEQKANEQKKESK 462
                   .:...|:...:|.|.|
  Fly   602 -------AIPPLQRLQVRKSERK 617

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC16A1	NP_001159968.1	2A0113	1..455	CDD:273325	139/599 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	454..500		3/9 (33%)
Mct1	NP_001284810.1	MFS	35..>213	CDD:119392	69/181 (38%)
		MFS	<426..604	CDD:119392	44/190 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145547
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2504
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D916876at2759
OrthoFinder	1	1.000	-	-		FOG0000033
OrthoInspector	1	1.000	-	-		mtm9818
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11360
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X70
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.850