Protein Alignment SLC13A1 and CG33934

DIOPT Version :10

• Sequence 1: XP_011514817.1
• Gene: SLC13A1 / 6561
• HGNCID: 10916
• Length: 651
• Species: Homo sapiens
• Sequence 2: NP_001163660.1
• Gene: CG33934 / 3772159
• FlyBaseID: FBgn0064119
• Length: 556
• Species: Drosophila melanogaster
• Alignment Length: 647
• Identity: 197/647 - (30%)
• Similarity: 301/647 - (46%)
• Gaps: 148/647 - (22%)

Human    21 LVLLPLPI--VLHTKEA-ECAYTLFVVATFWLTEALPLSVTALLPSLMLPMFGIMPSKKVASAYF 82
            |:.||:.|  ||....| :|.|.:..:|.||:|||:||.:|||.|.:.||:|||:.|:||.|.||
  Fly    32 LITLPIMIYGVLENNLAFQCMYLVANMALFWITEAIPLYLTALFPVVFLPLFGILTSEKVCSFYF 96

Human    83 KDFHLLLIGVICLATSIEKWNLHKRIALKMVMMVGVNPAWLTLGFMSSTAFLSMWLSNTSTAAMV 147
            .|..::.||.:.:|.:||..|||:||||..:::||.:|..|..|.:..|.|:|:|:||::..||:
  Fly    97 SDTVVMFIGGLLIALAIEYSNLHQRIALNTILIVGCSPRRLHFGLVMVTCFISLWISNSAATAMM 161

Human   148 MPIAEAVVQQIINAEAEVEATQMTYFNGSTNHGLEIDESVNGHEINERKEKTKPVPGYNNDTGKI 212
            .||.:||:.::                          |:.|...|.:.:|: :||
  Fly   162 CPIVKAVLNEM--------------------------ETQNIFAIYKTQEE-EPV---------- 189

Human   213 SSKVELEKEEEESNQQRVFTGSWVRKRMKLLLAYTLESHLLNKTLTFGLVIPQVKPFQDVPLSKN 277
                      ||.:.....|                    ::....||
  Fly   190 ----------EEGDPPHPST--------------------ISMAFYFG----------------- 207

Human   278 SGMRTKYRTKKGHVTRKLTCLCIAYSSTIGGLTTITGTSTNLIFAEYFNTRYPDC-RCLNFGSWF 341
                                  |||||:|||..|:.||.|||.:...::||:|:. ..::|..:.
  Fly   208 ----------------------IAYSSSIGGCGTLIGTGTNLTYKGLYDTRFPNSDEKIDFPIFM 250

Human   342 TFSFP-AALIILLLSWIWLQWLFLGFNFKEMFKCG---KTKTVQQKACAEVIKQEYQKLGPIRYQ 402
            .:|.| ..|:::.|::..||...:|. |:...|.|   |.....|....:||||...:|||:...
  Fly   251 AYSVPFVVLVLIFLTYFSLQVTHMGL-FRPNSKIGQEVKKGAESQDVVKDVIKQRKAELGPMSCH 314

Human   403 EIVTLVLFIIMALLWFSRDPGFVPGWS------ALFSEYP-GFATDSTVALLIGLLFFL------ 454
            ||...:||::|..|.|:|.|||.|||:      |:.|..| .|||....||.....||.
  Fly   315 EIQVGLLFVLMIFLLFTRKPGFFPGWADFLNAKAIGSGPPVFFATILLFALPTQYTFFKYCCGKA 379

Human   455 -IPAKTLTKTTPTGEIVAFDYSPLITWKEFQSFMPWDIAILVGGGFALADGCEESGLSKWIGNKL 518
             .|.:||              ...::|...|.:.|:.:|.|:|||||||:|...||::|.:|..|
  Fly   380 PFPGQTL--------------DACLSWVYCQKYTPFGLAFLLGGGFALAEGSRVSGMAKMLGESL 430

Human   519 SPLGSLPAWLIILISSLMVTSL--TEVASNPATITLFLPILSPLAEAIHVNPLYILIPSTLCTSF 581
            :..|.:.:  :::||..::.||  |..|||.|...:.:||.|.:|.||.|:|:.:..|:.|..|.
  Fly   431 AFAGEMHS--VLVISMCIIISLFCTAFASNVAICNILIPIFSEMALAIEVHPMKLTFPAALACSL 493

Human   582 AFLLPVANPPNAIVFSYGHLKVIDMVKAGLGVNIVGVAVVMLGICTWIVPMFDLYT-YPSWA 642
            ||.|||:.|||||:..:..||...|..||:.........::.....|.:.::...| :||||
  Fly   494 AFHLPVSTPPNAIISGFTGLKTKYMAIAGILPTCWAFLCLLFTGTVWTMLIYPGTTEFPSWA 555

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC13A1	XP_011514817.1	CitMHS	<7..171	CDD:460985	62/152 (41%)
		CitT	90..628	CDD:440239	158/558 (28%)
CG33934	NP_001163660.1	ArsB_NhaD_permease	<32..165	CDD:473875	59/132 (45%)
		CitT	104..540	CDD:440239	158/558 (28%)