Protein Alignment SLC12A4 and Ncc69

DIOPT Version :10

• Sequence 1: NP_001139434.1
• Gene: SLC12A4 / 6560
• HGNCID: 10913
• Length: 1087
• Species: Homo sapiens
• Sequence 2: NP_001261758.1
• Gene: Ncc69 / 39410
• FlyBaseID: FBgn0036279
• Length: 1207
• Species: Drosophila melanogaster
• Alignment Length: 1346
• Identity: 327/1346 - (24%)
• Similarity: 517/1346 - (38%)
• Gaps: 429/1346 - (31%)

Human     2 RAGGACRPGAAGTAAGTAAGGWDGGCGGAEPARCLTS---------------------PWCQ--- 42
            ::.||..|| :|:.||..||...|..|..|..|.||:                     |..|
  Fly    31 KSQGADGPG-SGSGAGAGAGAGAGEDGPHEVYRRLTNAEGELLEDDTFDATQMLNQRQPRQQRQS 94

Human    43 ---------WTGRGAATMTTSRGSVGWTTGSAPSWMTRTEELDI-------------RPKVSSLL 85
                     ...|.....||:|..|......:.......||.::             |......|
  Fly    95 IKSSFRDKDKPSRFKDLQTTTRFQVDPQNEESDESNDSQEERELLDNEYDTKYGKSFRHFTREAL 159

Human    86 GKLVSYTNL-----------------------TQGAKEHEEAESG--EGTRRRAAEAPSMGTLMG 125
            .:|.:|.|:                       |.....:::.|||  .|..:       .|.:.|
  Fly   160 PRLDNYRNMMSIQAAYRPTLDELHNATLVGKNTHSLTRNQDPESGILNGVLK-------FGWIKG 217

Human   126 VYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNGVVPAGGSYFM 190
            |.:.||.||:||:|||||:|:||.|||::..:::|.....|.:||:|||||:||||:..||:|:|
  Fly   218 VLVRCLLNIWGVMLFLRLSWVVGQAGVIEGFVLILTTTAVTTITALSMSAISTNGVIKGGGTYYM 282

Human   191 ISRSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPAAIFYPSGAHDTSNATLNNMRV 255
            |||||||||||::||.|.|....|.|||::|..|.:|..:..........|..|        :|:
  Fly   283 ISRSLGPEFGGSIGLIFSLANAVACAMYVVGFCESMLAMMTTFGWEIIDGGVQD--------VRI 339

Human   256 YGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISILSIYAGGIKSIFDPPVFPVCMLGNRTLSRD 320
            .|.|.:..:.::|.||:::..|.....|..::::|.....|.             .:|.::
  Fly   340 IGCITILLLLIIVVVGMEWEAKAQIGLLIILLVAIGDFVIGS-------------FIGPKS---- 387

Human   321 QFDICAKTAVVDNETVATQLWSFFCHSPNLTTDSCDPYFMLNNVTEIPGIPGAAAGVLQENLWSA 385
                       |.|..                               .|..|..|.:.:.||::.
  Fly   388 -----------DAEMA-------------------------------KGFLGYNATLFKNNLFAD 410

Human   386 YL-EKGDIVEKHGLPSADAPSLKESLPLYVVADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDA 449
            |. |||.|  :|                        .|..:..||||:.|||:||:|.||||:|.
  Fly   411 YRPEKGGI--QH------------------------DFFSVFAIFFPAATGILAGANISGDLKDP 449

Human   450 QKSIPVGTILAIITTSLVYFSSVVLFGACIEGVVLRDKYGDGVSRNLVVGTLAW----PSPW--- 507
            |||||.||||||:.|:..|...|:..||    .|.||..|:  ..::|.||.|:    |...
  Fly   450 QKSIPKGTILAIVITTGTYLIMVLQCGA----TVARDATGN--LSDVVNGTFAFLDCQPGECNYG 508

Human   508 ----------------VIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVF--GHGKVNG 554
                            :|..|.:.:|..:.|.||..||::.||:.||.:.|.:..|  |:|| |.
  Fly   509 LQNSFQVIELVSAFGPLIYAGCYAATLSSALASLVSAPKVFQALCKDELYPKIVWFAKGYGK-NN 572

Human   555 EPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWA 619
            ||....:||.:||...|||..|:::||::|.|||..|:.:|.:....:|.:...|||.||||:..
  Fly   573 EPVRGYVLTFIIACAFILIGELNLIAPLISNFFLAAYMLINFSTFHASLAKPVGWRPTFKYYNMW 637

Human   620 LSFLGMSLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEE 684
            ||.||..||:|:||:.||..||:.......:|..:.|:..:..||...:..:...|..::.:|..
  Fly   638 LSLLGAILCVAVMFLISWATALITFAAVLALYLIVAYRKPDVNWGSTTQAQTYKNALMSVQQLNN 702

Human   685 GPPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQAAEQ 749
            ...|.||:|||:|||..|..    ..|.|:..|..|.....|.:.|.|::||..:.|  ....::
  Fly   703 VEEHVKNYRPQILVLSGLPN----TRPVLVDLAYMLTKNLSLLVCGHVLKGSSSQKY--RTYLQE 761

Human   750 TIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYGWRQ----------- 803
            ...|.....:||||..:|.......|...|:|:.|:|.::.|.:::|:...|:.
  Fly   762 RAGNWFRKHRVKGFYALVDGEDFESGTRALMQATGIGKLKPNIILMGYKTDWQTCDHKELDQYFN 826

Human   804 ----------------------------SEDPRAWKTFIDTVR---------------------- 818
                                        |:|  .|||..|..|
  Fly   827 VMHKALDMYLSVAILRVPQGLDCSQVLGSQD--GWKTVSDVPRTLQPNESSGDLQAVDSSVRNGL 889

Human   819 --------------------CTTAAHLALLVPK---------------------NIAFYPSNHER 842
                                ...:...:|.:.|                     :::|...|..:
  Fly   890 SGSIDSLSRNVSQEDRNRNQLVHSEQNSLKIVKLRFKQGLRRMRSWPGAASSTSDLSFIAGNQSK 954

Human   843 YLEG-------------------------------------------------------H--IDV 850
            .:.|                                                       |  |||
  Fly   955 DVSGMPDPLDAKSANLVSNSLRKSKLKHDDPASLYKGPGGAELPKEVLADLTQFTRKRSHAVIDV 1019

Human   851 WWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKDLAVFLYHLRLEAEVEVVEM 915
            ||:..|||:.:|||:::...:.|:.|::|::.:|..:......::.:|..|...|::
  Fly  1020 WWLYDDGGLTLLLPYIISTRRTWQSCKLRVYALANKNSELEFEQRSMASLLSKFRID-------- 1076

Human   916 HNSDISAYTYERTLMMEQRSQMLRQMRLTKTEREREAQ----LVKDRHSALRLESLYSDEEDESA 976
             .||:       ||:.:          :||..:|...|    |:||        .:.::::.|:.
  Fly  1077 -YSDL-------TLIPD----------ITKKPQETSTQFFNELIKD--------FVVTEKDGENG 1115

Human   977 VGADKIQMTWTRDKYMTETWDPSHAPDNFRELVHIKPDQSNVRRMHTAVKLNEVIVTRSHDARLV 1041
            ..:   :.|...|..:....|          |:.:: |::|     ..::|.|.:..:|..:.||
  Fly  1116 TSS---RATLNEDDALITDDD----------LLAVQ-DKTN-----RYLRLREYLREQSTKSDLV 1161

Human  1042 LLNMPGPPRNSEGDENYMEFLEVLTEGLERVLLVRGGGREVITIYS 1087
            ::.:|.|.:|......||.:||.|:..:...|.|||....|:|.||
  Fly  1162 VMTLPMPRKNIVSAPLYMAWLESLSRDMPPFLFVRGNQTSVLTFYS 1207

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC12A4	NP_001139434.1	2a30	70..1087	CDD:273347	303/1243 (24%)
Ncc69	NP_001261758.1	AA_permease_2	155..1207	CDD:459263	300/1219 (25%)