DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC12A4 and kcc

DIOPT Version :9

Sequence 1:	NP_001139434.1	Gene:	SLC12A4 / 6560	HGNCID:	10913	Length:	1087	Species:	Homo sapiens
Sequence 2:	NP_001286795.1	Gene:	kcc / 37800	FlyBaseID:	FBgn0261794	Length:	1077	Species:	Drosophila melanogaster

Alignment Length:	1060	Identity:	595/1060 - (56%)
Similarity:	764/1060 - (72%)	Gaps:	68/1060 - (6%)

- Green bases have known domain annotations that are detailed below.

Human    66 PSWMTRTEELDIRPKVSSLLGKLVSYTNLTQGAKEHEEAESGEGTRRRAAEAPSMGTLMGVYLPC 130
            |:.....::|:.||.:|:.:..:.:|.|....|.:.:        .:.||.:..||||:||:|||
  Fly    48 PNLYLYDDDLETRPHISTFISSIANYENTIPAATDPD--------AKPAAPSARMGTLIGVFLPC 104

Human   131 LQNIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNGVVPAGGSYFMISRSL 195
            :|||||||||:||||:|||||.:...||||.|||.|:||||||||||||||||||||||||||||
  Fly   105 IQNIFGVILFIRLTWVVGTAGAVCGFLIVLTCCCVTMLTAISMSAIATNGVVPAGGSYFMISRSL 169

Human   196 GPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPAAIFYPSGAHDTSNATLNNMRVYGTIF 260
            |||||||||:.||.|||.||||||:||:||:|||:||.|:||  ......::|..||.|||||:.
  Fly   170 GPEFGGAVGMLFYTGTTLAAAMYIVGAVEIVLTYMAPWASIF--GDFTKDADAMYNNFRVYGTLL 232

Human   261 LTFMTLVVFVGVKYVNKFASLFLACVIISILSIYAGGIKSIFDPPVFPVCMLGNRTLSRDQFDIC 325
            |.||.|:||:|||:|||||::.|||||:||:::|.|...:|.......:|:||.|.|.....:.|
  Fly   233 LIFMGLIVFLGVKFVNKFATVALACVILSIIAVYVGIFDNIHGNEKLYMCVLGKRLLKDIPLENC 297

Human   326 AKTAVVDNETVATQLWSFFCHSPNLTTDSCDPYFMLNNVTEIPGIPGAAAGVLQENLWSAYLEKG 390
            .|.        .:.|...:|  |:   ..|:.|::.||||::.||.|.|:||..:|::.::||||
  Fly   298 TKE--------DSFLRDIYC--PD---GKCEEYYLANNVTKVKGIKGLASGVFYDNIFPSFLEKG 349

Human   391 DIVEKHGLPSADAPSLKESLPLYVVADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPV 455
            ..: .:|..:.|..:........::|||.||||:|:||||||||||||||||||||.|||||||:
  Fly   350 QFI-SYGKSAIDIENTSGESYNQIMADITTSFTLLIGIFFPSVTGIMAGSNRSGDLADAQKSIPI 413

Human   456 GTILAIITTSLVYFSSVVLFGACIEGVVLRDKYGDGVSRNLVVGTLAWPSPWVIVIGSFFSTCGA 520
            |||.||:|||.||.|||:.|...::.::||||:|..:...|||..:|||:.|||:||||.||.||
  Fly   414 GTICAILTTSTVYLSSVMFFAGTVDNLLLRDKFGQSIGGKLVVANIAWPNQWVILIGSFLSTLGA 478

Human   521 GLQSLTGAPRLLQAIAKDNIIPFLRVFGHGKVNGEPTWALLLTALIAELGILIASLDMVAPILSM 585
            ||||||||||||||||:|.|||||..|......||||.|||||.:|.:.|||:.::|::||:|||
  Fly   479 GLQSLTGAPRLLQAIARDEIIPFLAPFAKSSKRGEPTRALLLTIVICQCGILLGNVDLLAPLLSM 543

Human   586 FFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGMSLCLALMFVSSWYYALVAMLIAGMI 650
            ||||||.||||||||||||||||||||||:|||:||.:|::||:::|.::|||:||:||.:|.:|
  Fly   544 FFLMCYGFVNLACAVQTLLRTPNWRPRFKFYHWSLSLIGLTLCISVMIMTSWYFALIAMGMAIII 608

Human   651 YKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKYPRLLT 715
            ||||||:||||||||||||::|:||||:|||||||||||||||||:|||.||:::|..||.::.:
  Fly   609 YKYIEYRGAEKEWGDGIRGMALTAARYSLLRLEEGPPHTKNWRPQILVLSKLNDNLLPKYRKIFS 673

Human   716 FASQLKAGKGLTIVGSVIQGSFLESYGEAQAAEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLI 780
            ||:||||||||||..|||:|...:...:|..|:.|::..|..|||||||.|:||.::.|||:.:|
  Fly   674 FATQLKAGKGLTICVSVIKGDHTKITNKAVDAKATLRKYMTDEKVKGFCDVLVAQQIGEGLSSVI 738

Human   781 QSCGLGGMRHNSVVLGWPYGWRQSEDPRAWKTFIDTVRCTTAAHLALLVPKNIAFYP-SNHERYL 844
            |:.|||||:.|:|::||||.||| |...:|||||.|||...|.|:||:|||.|.||| |||:  :
  Fly   739 QTIGLGGMKPNTVIIGWPYSWRQ-EGRNSWKTFIQTVRTVAACHMALMVPKGINFYPESNHK--I 800

Human   845 EGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKDLAVFLYHLRLEAE 909
            .|:||:||||||||:||||||||:||:.||.|::|||||||::||||||||||..||||||:||:
  Fly   801 GGNIDIWWIVHDGGLLMLLPFLLKQHRTWRNCKLRIFTVAQIEDNSIQMKKDLKTFLYHLRIEAD 865

Human   910 VEVVEMHNSDISAYTYERTLMMEQRSQMLRQMRLTKTEREREAQLVKD-----RHSALRLESLYS 969
            ||||||:||||||||||||||||||:||||.:.|.|.|..:..|.:.|     ..:.:.|.....
  Fly   866 VEVVEMNNSDISAYTYERTLMMEQRNQMLRALGLNKKENSKVVQTIMDYKETPSDNKMSLVQTIV 930

Human   970 DEEDESAVGADKIQMTWTRDKYMTETWDPSHAPDNFRELV------------------------- 1009
            |...::...|.|::..   |..:.||.......|..|..:
  Fly   931 DHHYDATKTASKVRFA---DPTIEETQHHDSQNDEKRNSIDLDGPENADTPETTSNKDESTEKAD 992

Human  1010 -----HIKPDQSNVRRMHTAVKLNEVIVTRSHDARLVLLNMPGPPR--NSEGDENYMEFLEVLTE 1067
                 .:|||:.||||||||:|||||||.:|.||:||::|:|||||  .:|.:.|||||||||||
  Fly   993 GDFKSSVKPDEFNVRRMHTAIKLNEVIVEKSQDAQLVIMNLPGPPREVRAERERNYMEFLEVLTE 1057

Human  1068 GLERVLLVRGGGREVITIYS 1087
            |||:||:|||||||||||||
  Fly  1058 GLEKVLMVRGGGREVITIYS 1077

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC12A4	NP_001139434.1	2a30	70..1087	CDD:273347	592/1054 (56%)
		SLC5-6-like_sbd	144..>305	CDD:294310	107/160 (67%)
		SLC12	711..1087	CDD:281515	220/413 (53%)
kcc	NP_001286795.1	2a30	49..1077	CDD:273347	592/1057 (56%)
kcc	NP_001286795.1	SLC12	674..1077	CDD:281515	220/408 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158234
Domainoid	1	1.000	426	1.000	Domainoid score	I605
eggNOG	1	0.900	-	-		E2759_KOG2082
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H21056
Inparanoid	1	1.050	1162	1.000	Inparanoid score	I205
Isobase	1	0.950	-	0	Normalized mean entropy	S2108
OMA	1	1.010	-	-		QHG57166
OrthoDB	1	1.010	-	-		D110005at33208
OrthoFinder	1	1.000	-	-		FOG0000627
OrthoInspector	1	1.000	-	-		otm41076
orthoMCL	1	0.900	-	-		OOG6_101034
Panther	1	1.100	-	-	LDO	PTHR11827
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3041
SonicParanoid	1	1.000	-	-		X451
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750