Protein Alignment SLC12A4 and CG10413

DIOPT Version :9

• Sequence 1: NP_001139434.1
• Gene: SLC12A4 / 6560
• HGNCID: 10913
• Length: 1087
• Species: Homo sapiens
• Sequence 2: NP_001286048.1
• Gene: CG10413 / 35111
• FlyBaseID: FBgn0032689
• Length: 941
• Species: Drosophila melanogaster
• Alignment Length: 1121
• Identity: 288/1121 - (25%)
• Similarity: 458/1121 - (40%)
• Gaps: 285/1121 - (25%)

Human    69 MTRTEELDIRPKVSSLLGK----LVSYTNLTQGAKEHEE----AESGEGTRRRAAEAP-----SM 120
            |:.:.|.:..|..:|..|:    ..|:.:|..|::...:    .:.|:|......:.|     ::
  Fly     1 MSASAEQETAPIANSRSGRTGSVFRSFGSLFGGSQNSGDRPHTPQDGDGYVEFGMQDPDRSGRTL 65

Human   121 GTLMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNGVVPAG 185
            ||..||:.|...::|..::|:|:.::||.||:...||..||.....|.|..|:.||:|||.:..|
  Fly    66 GTFAGVFSPVALSMFSALVFIRVGYIVGNAGLYVTLLQFLIAYGILLFTVASVCAISTNGAIEGG 130

Human   186 GSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPAAIFYPSGAH------- 243
            |.||||||:||.||||::|..|:......:||.|.|..|.::.... |...|....:|
  Fly   131 GVYFMISRTLGLEFGGSIGTLFFFANVVGSAMAISGCTEGIMDNFG-PRGHFVSGDSHLPDGDWW 194

Human   244 -DTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISILSIYAGGIKSIFDPPVF 307
             ..:::.:|          |...||..||.....|.:.:.||.|.:.:.:.|            |
  Fly   195 RFLTSSMIN----------TLQLLVCLVGAALFAKTSVIILATVTVCLFATY------------F 237

Human   308 PVCMLGNRTLSRDQFDICAKTAVVDNETVATQLWSFFCHSPNLTTDSCDPYFMLNNVTEIPGIPG 372
            ....:|                 ..|.|:.            :..|:     :|:|.|......|
  Fly   238 SFLFVG-----------------ATNNTIP------------VPGDN-----ILSNTTTFLDYTG 268

Human   373 AAAGVLQENLWSAYLEKGDIVEKHGLPSADAPSLKESLPLYVVADIATSFTVLVGIFFPSVTGIM 437
            ..|..|::||.|.|   |.....:|         |:       .|.:|:|    |:.|..|||||
  Fly   269 LNATTLRDNLGSHY---GRDYTSNG---------KQ-------VDFSTTF----GVLFSGVTGIM 310

Human   438 AGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIEGVVLRDKYGDGVSRNLVVGTLA 502
            ||:|.||:|::..||||.||:.|:..|.:.|.....|.........:::.|...:..||
  Fly   311 AGANMSGELKNPSKSIPYGTLSAVAFTFVSYIILSFLMSCTTPYFTMQNNYLFLMPVNL------ 369

Human   503 WPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFG-------HGKVNGEPTWAL 560
            || |:. .||...:|....|.:|.|:.|:|:|::||      :|||       ||...|.|..|:
  Fly   370 WP-PFT-AIGILTATFSTSLSNLIGSSRILEALSKD------QVFGSLLNFVIHGTWKGNPIAAV 426

Human   561 LLTALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGM 625
            .::..:.|..:||.|.:::|.|.|:.|::.||..||||....|...||:||.||::.|....:|:
  Fly   427 AVSWCLVECILLIGSFNIIAQINSVLFMLSYLATNLACLGIELTGAPNFRPLFKFFTWHTCLVGL 491

Human   626 SLCLALMFVSSWYYA---LVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEGPP 687
            ...|.:|||.::.||   ::..||..:............:||...:.|.....|..||.|:....
  Fly   492 LGTLIMMFVINFIYASSCIILCLILVIALHLFSPATQAAQWGSISQALMFHQVRKYLLMLDPRKD 556

Human   688 HTKNWRPQLLVLLKLDEDLHVKYPR----LLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQAAE 748
            |.|.||||:|:|        |..||    |:.|.:.||. .||.|:|.|..|.| :...:|:..:
  Fly   557 HVKFWRPQILLL--------VSSPRSCCPLVDFVNDLKK-SGLYIIGHVKLGDF-KGIEDAEDNQ 611

Human   749 QTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGW---------------P 798
            |. .:.::..:||.|.:|.::..:|||:.|||:..|:|.|:.|:::||:               |
  Fly   612 QW-WSFLDHMRVKAFTEVTLSRSIREGVQHLIRLSGIGAMKPNTIILGFYDSEAPRDFFQNGSSP 675

Human   799 YGW-------------RQSEDPRAW------KTFIDTVR-------CTTAAHLALLVPKNIAFYP 837
            |..             |:..||:.:      :...||:|       |.....|    .||. ...
  Fly   676 YKTDDFNNGEIQNFPIRRDGDPKQFQIQEYVQILCDTLRMKKNLCLCRNFQRL----DKNF-ISM 735

Human   838 SNHERYLEGHIDVWWI----VHDGGMLMLLPFLLRQHKV-----WRKCRMRIF--------TVAQ 885
            |.|.:|    ||||.|    ...|....::...:.|..|     |:..|:|||        ||..
  Fly   736 SKHVKY----IDVWPINIFNPTSGDPFDMVSLFMMQLAVIMLAKWKHLRVRIFLCEANDERTVGT 796

Human   886 MDDNSIQM----KKDLAVFLYHLRLEAEVEVVEMHNSDISAYTYERTLMMEQRSQMLRQMRLTKT 946
            .|..:.||    |..|...|..||:.|::..::..:.|.....:.|||
  Fly   797 FDTQTPQMEIFSKMKLEQSLKELRITADIVEIQEWSRDTDFSRHARTL----------------- 844

Human   947 EREREAQLVKDRHSALRLESLYSDEEDESAVGADKIQMTWTRDKYMTETWDPSHAPDNFRELVHI 1011
                       :....:.:::..:::||  ||.:.:.                      |.|:::
  Fly   845 -----------KQFTAQADNVVLEDDDE--VGEETLN----------------------RSLLYM 874

Human  1012 KPDQSNVRRMHTAVKLNEVIVTRSHDARLVLLNMPGPPRNSEGD-----ENYMEFLEVLTEGLER 1071
            :             :.|::|..||....|..:.:..||:.|..|     .:|||.|..||..|..
  Fly   875 Q-------------RANQIIRERSDQTALSFIYLAAPPKLSAPDFAQRSASYMELLTELTADLPP 926

Human  1072 VLLVRGGGREVITIYS 1087
            .:||.|    |.|:.|
  Fly   927 TILVHG----VSTVTS 938

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC12A4	NP_001139434.1	2a30	70..1087	CDD:273347	286/1118 (26%)
		SLC5-6-like_sbd	144..>305	CDD:294310	51/168 (30%)
		SLC12	711..1087	CDD:281515	101/446 (23%)
CG10413	NP_001286048.1	2a30	22..932	CDD:273347	279/1088 (26%)
		SLC12	577..932	CDD:281515	96/431 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158233
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840