DRSC/TRiP Functional Genomics Resources

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Protein Alignment BMP8B and scw

DIOPT Version :9

Sequence 1:XP_011540326.2 Gene:BMP8B / 656 HGNCID:1075 Length:427 Species:Homo sapiens
Sequence 2:NP_001286088.1 Gene:scw / 46000 FlyBaseID:FBgn0005590 Length:400 Species:Drosophila melanogaster


Alignment Length:432 Identity:117/432 - (27%)
Similarity:188/432 - (43%) Gaps:119/432 - (27%)


- Green bases have known domain annotations that are detailed below.


Human    45 QREILAVLGLPGRPRPRAPPAASRLPASAPLFMLDLY----------------HAMAGDDD---- 89
            |.|::.:|.|..|||.:|.|   .|..||..|:|::|                |..:.|||    
  Fly    39 QMEMIDILDLGDRPRRQAEP---NLHNSASKFLLEVYNEISEDQEPKEVLHQRHKRSLDDDILIS 100

Human    90 -EDGAPAERRLGRADLVMSFVNMVERDRALGHQEPHWKEFRFDLTQIPAGEAVTAAEFRIYKVPS 153
             ||    .:.:...:.:::|.:.::.::.....:.|   ..|:...:|...::..|..||||.||
  Fly   101 NED----RQEIASCNSILTFSSRLKPEQLDNELDMH---ITFNTNDVPVDLSLVQAMLRIYKQPS 158

Human   154 IHLLNRTLHVSMFQVVQEQSNRESDLFFLDLQTLR--AGDEGWLVLDVTAASDCWL----LKRHK 212
              |::|..:.:: .|.::..||: |..:..|.::.  :...|||..::|.....||    |:|..
  Fly   159 --LVDRRANFTV-SVYRKLDNRQ-DFSYRILGSVNTTSSQRGWLEFNLTDTLRYWLHNKGLQRRN 219

Human   213 DLGLRLYVETEDGETWTGWGWTKDSRLQMWKLRL-----SRT---PWVLSLHAPGPAQAPAERPL 269
            :|.:.:                .||:|..:...|     |||   |:::. :..||       .|
  Fly   220 ELRISI----------------GDSQLSTFAAGLVTPQASRTSLEPFIVG-YFNGP-------EL 260

Human   270 LCLLQ--------------GHCPASPSPIRTPRAVRPLRRRQPKKSNELPQANRLPGIFDDVHGS 320
            |..:|              |..|..|.|       .|:...:|.:|                   
  Fly   261 LVKIQKLRFKRDLEKRRAGGGSPPPPPP-------PPVDLYRPPQS------------------- 299

Human   321 HGRQVCRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNATNHAILQSLVHLMMPD 385
                 |.|....|.|::|...:|||||:.:.||:|.|.|:|||.:.||||||||:|:|:||..|.
  Fly   300 -----CERLNFTVDFKELHMHNWVIAPKKFEAYFCGGGCNFPLGTKMNATNHAIVQTLMHLKQPH 359

Human   386 AVPKACCAPTKLSATSVLYYDSSNNVILRKHRNMVVKACGCH 427
             :||.||.||.|.|.::|.|.:.:.:.|.|::..|.|.||||
  Fly   360 -LPKPCCVPTVLGAITILRYLNEDIIDLTKYQKAVAKECGCH 400

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
BMP8BXP_011540326.2 None
scwNP_001286088.1 TGFb_propeptide 39..254 CDD:279078 56/245 (23%)
TGFB 300..400 CDD:214556 47/100 (47%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3900
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1063560at2759
OrthoFinder 1 1.000 - - FOG0000576
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11848
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X157
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
87.880

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