Protein Alignment SLC12A2 and VHC1

DIOPT Version :10

• Sequence 1: NP_001037.1
• Gene: SLC12A2 / 6558
• HGNCID: 10911
• Length: 1212
• Species: Homo sapiens
• Sequence 2: NP_009794.3
• Gene: VHC1 / 852537
• SGDID: S000000439
• Length: 1120
• Species: Saccharomyces cerevisiae
• Alignment Length: 936
• Identity: 241/936 - (25%)
• Similarity: 414/936 - (44%)
• Gaps: 188/936 - (20%)

Human   264 ESTPTRDAVVT-YTAESKGVVKFGWIKGVLVRCMLNIWGVMLFIRLSWIVGQAGIGLSVLVIMMA 327
            ::||....|.: |..::....|.|...||.|...||:..:::|:|..:|:||.||..::.:::::
Yeast    41 QATPECQKVSSKYDPDNPNKDKLGTYDGVFVPTALNVLSILMFLRFGFILGQLGIICTIGLLLLS 105

Human   328 TVVTTITGLSTSAIATNGFVRGGGAYYLISRSLGPEFGGAIGLIFAFANAVAVAMYVVGFAETVV 392
            ..:..:|.||.|||:|||.||||||||:|||||||||||:|||:|.........|..||..|.::
Yeast   106 YTINLLTTLSISAISTNGTVRGGGAYYMISRSLGPEFGGSIGLVFFLGQVFNAGMNAVGIIEPLL 170

Human   393 ----------------ELLKE---HSILMIDEINDIRIIGAITVVILLGISVA--GMEWEAKAQI 436
                            |||..   |....            .||::.|..|||  |.:..::|..
Yeast   171 YNLGYSAQGEPPAALGELLPRGHWHEFTY------------ATVILFLCFSVAFVGSQTVSRAGN 223

Human   437 VLLVILLLAIGDFVIGTFIPLESKKPKGFFGYKS---EIFNENFGPD---------FREEETFFS 489
            :|.::|..:|  |.|.....:.|...:|...|..   :.|::|..|.         .:.:|||..
Yeast   224 ILFLVLAASI--FSIPLSALIRSPFTEGGISYTGPSWQTFHDNLLPHLTKGAAGSLLKGKETFND 286

Human   490 VFAIFFPAATGILAGANISGDLADPQSAIPKGTLLAILITTLVYVGIAVSVGSCVVRDATGNVND 554
            :|.:||||..||.|||.:|.:|..|..:||||||..:|.|.:.|..:..|:|..:.|.:
Yeast   287 LFGVFFPATAGIFAGAGMSSELRKPSKSIPKGTLWGLLFTFICYAVVVFSMGCSIPRRS------ 345

Human   555 TIVTELTNCTSAACKLNFDFSSCESSPCSYGLMNNFQVMSMVSGFTPLISAGIFSATLSSALASL 619
                                           |.:..|::..:|....:|..|..:.:|.|.:..:
Yeast   346 -------------------------------LYDEVQIIQTISSVQWVIFMGEMATSLFSIIVGM 379

Human   620 VSAPKIFQALCKDNIYPAFQMFAKGYGKNNEPLRGYILTFLIALGFILIAELNVIAPIISNFFLA 684
            :.|..:.:|:.||||.|..::||      :.||...|.|:::. ...|.:::|.||..|:..||.
Yeast   380 LGAAYVLEAIAKDNIIPGLEIFA------HSPLYSLIFTWILT-QLCLFSDVNKIATFITMTFLM 437

Human   685 SYALINFSVFHASLAKSPGWRPAFKYYNMWISLLGAILCCIVMFVINWWAALLTYVIVLGLYIYV 749
            ::.::|.:.|...::.:|.:||:|||:|.:.:.:||:|..:.|.:::..:|.:.::.::.|::::
Yeast   438 TFVVMNLACFLLGISSAPNFRPSFKYFNRYTTAIGALLSVVAMLIVDGISASVLFLAMILLFLFI 502

Human   750 TYKKPDVNWGSSTQALTYLNALQHSIRLSGVEDHVKNFRPQCLVMTGAPNSRPALLHLVHDFTKN 814
            .|..|..:||..:|:|.|....::.:||.  :|::|.:|||.|:....|.:...|:...:...|.
Yeast   503 HYFSPPKSWGDVSQSLIYHQVRKYLLRLR--QDNIKYWRPQILLFVDNPRTSWNLIRFCNHLKKG 565

Human   815 VGLMICGHVHMG---PRRQAMKEMSIDQAKYQRWLIKNKMKAFYAPVHADDLREGAQYLMQAAGL 876
             ||.|.|||.:.   |::  :.|:...|..:.:......:|||........|..|.:.:...:||
Yeast   566 -GLYILGHVAVTADFPKQ--LNELKTQQKAWMKIRDMAAIKAFVQVGTGPSLIWGIRNVFIGSGL 627

Human   877 GRMKPNTLVLGFKKDWLQADMRDVDMYINLFHDAFDIQYGVVVIRLKEGLDISHLQGQEELLSSQ 941
            |.||||..|:||         .|::.|..               .:.:....::||.|.|:.::.
Yeast   628 GGMKPNITVVGF---------FDLESYRK---------------HIPQSRSQNNLQKQVEIKATV 668

Human   942 EKSPGTKDVVVSVEYSKKSDLDTSKPLSEKPITHKVEEEDGKTATQPLLKKESKGPIVPLNVA-- 1004
            .:|. ..||.::|..          |..|.....||..:......:.|...:|       |:|
Yeast   669 PRST-CSDVKINVPL----------PTDECKNETKVNVQQWVQIVEDLSLMQS-------NIAIA 715

Human  1005 -DQKLLEASTQFQKKQGKNTIDVWWL-------------------FDDGGLTLLIPYLLTTKKKW 1049
             ..|.||...:......|.|||::.:                   ||...|.|.:..:|.|..:|
Yeast   716 HGFKNLEIPNKRDSCFPKKTIDLYPIQMCGKVEAKGDQPAAITTNFDTYTLILQLAAILVTVPEW 780

Human  1050 K---DCKIRVFIGGKINRIDHDRRAMATLLSKFRIDFSDIMVLGD----INTKPKKENIIAFEEI 1107
            |   ..::.:|:..:.:|.:..:| |..||...|||...::|..|    .||      |:..:.|
Yeast   781 KRTHSLRVILFVEQEYHRTNETQR-MKKLLQVLRIDAEVLVVSLDQFRVYNT------IVKGDPI 838

Human  1108 IEPYRLHEDDKEQDIADKMKEDEPWR 1133
            :..|          :..|:.::|.|:
Yeast   839 VFDY----------VNSKLADNEWWK 854

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC12A2	NP_001037.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	36..81
		RFXV motif 1. /evidence=ECO:0000269|PubMed:16669787	80..83
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	112..138
		RFXV motif 2. /evidence=ECO:0000269|PubMed:16669787	138..141
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	150..193
		2a30	216..1212	CDD:273347	241/936 (26%)
		Scissor helix. /evidence=ECO:0000269|PubMed:35585053, ECO:0000269|PubMed:36306358, ECO:0007744|PDB:7MXO, ECO:0007744|PDB:7N3N, ECO:0007744|PDB:7S1X, ECO:0007744|PDB:7SFL, ECO:0007744|PDB:7SMP	761..778		4/16 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	962..989		4/26 (15%)
VHC1	NP_009794.3	AA_permease_2	45..824	CDD:459263	230/884 (26%)