Protein Alignment SLC12A2 and Ncc69

DIOPT Version :10

• Sequence 1: NP_001037.1
• Gene: SLC12A2 / 6558
• HGNCID: 10911
• Length: 1212
• Species: Homo sapiens
• Sequence 2: NP_001261758.1
• Gene: Ncc69 / 39410
• FlyBaseID: FBgn0036279
• Length: 1207
• Species: Drosophila melanogaster
• Alignment Length: 1271
• Identity: 559/1271 - (43%)
• Similarity: 758/1271 - (59%)
• Gaps: 196/1271 - (15%)

Human    65 GDGLGRPLGPTPSQSRFQVDLVSENAGRAAAAAAAAAAAAAAAGAGAGA----------KQTPAD 119
            |....||      .:||||:.|:.|:.::..|....:.:.|.|||||||          :.|.|:
  Fly    10 GSAADRP------PNRFQVNPVNGNSRKSQGADGPGSGSGAGAGAGAGAGEDGPHEVYRRLTNAE 68

Human   120 GE-----------ASGESEPAKGSEEAKGRFRVNFVDPAASSSAEDSLSDAAGVGVDGPNVSFQN 173
            ||           ...:.:|.:..:..|..||    |....|..:| |.......||..|.....
  Fly    69 GELLEDDTFDATQMLNQRQPRQQRQSIKSSFR----DKDKPSRFKD-LQTTTRFQVDPQNEESDE 128

Human   174 GGDTVLSEGSSLHSGGGGGSGHHQHYYYDTHTNTYYLRTFGHNTMDAVPRIDHYRHTAAQLGEKL 238
            ..|:                 ..:....|...:|.|.::|.|.|.:|:||:|:||:..:.  :..
  Fly   129 SNDS-----------------QEERELLDNEYDTKYGKSFRHFTREALPRLDNYRNMMSI--QAA 174

Human   239 LRPSLAELHDEL-----------EKEPFEDGFANGEESTPTRDAVVTYTAESKGVVKFGWIKGVL 292
            .||:|.|||:..           .::| |.|..|                   ||:|||||||||
  Fly   175 YRPTLDELHNATLVGKNTHSLTRNQDP-ESGILN-------------------GVLKFGWIKGVL 219

Human   293 VRCMLNIWGVMLFIRLSWIVGQAGIGLSVLVIMMATVVTTITGLSTSAIATNGFVRGGGAYYLIS 357
            |||:|||||||||:||||:|||||:....::|:..|.|||||.||.|||:|||.::|||.||:||
  Fly   220 VRCLLNIWGVMLFLRLSWVVGQAGVIEGFVLILTTTAVTTITALSMSAISTNGVIKGGGTYYMIS 284

Human   358 RSLGPEFGGAIGLIFAFANAVAVAMYVVGFAETVVELLKEHSILMID-EINDIRIIGAITVVILL 421
            |||||||||:|||||:.|||||.|||||||.|:::.::......:|| .:.|:||||.||:::||
  Fly   285 RSLGPEFGGSIGLIFSLANAVACAMYVVGFCESMLAMMTTFGWEIIDGGVQDVRIIGCITILLLL 349

Human   422 GISVAGMEWEAKAQIVLLVILLLAIGDFVIGTFI--PLESKKPKGFFGYKSEIFNENFGPDFREE 484
            .|.|.||||||||||.||:|||:||||||||:||  ..:::..|||.||.:.:|..|...|:|.|
  Fly   350 IIVVVGMEWEAKAQIGLLIILLVAIGDFVIGSFIGPKSDAEMAKGFLGYNATLFKNNLFADYRPE 414

Human   485 E-----TFFSVFAIFFPAATGILAGANISGDLADPQSAIPKGTLLAILITTLVYVGIAVSVGSCV 544
            :     .|||||||||||||||||||||||||.|||.:|||||:|||:|||..|:.:.:..|:.|
  Fly   415 KGGIQHDFFSVFAIFFPAATGILAGANISGDLKDPQKSIPKGTILAIVITTGTYLIMVLQCGATV 479

Human   545 VRDATGNVNDTIVTELTNCTSAACKLNFDFSSCESSPCSYGLMNNFQVMSMVSGFTPLISAGIFS 609
            .||||||::|.:     |.|       |.|..|:...|:|||.|:|||:.:||.|.|||.||.::
  Fly   480 ARDATGNLSDVV-----NGT-------FAFLDCQPGECNYGLQNSFQVIELVSAFGPLIYAGCYA 532

Human   610 ATLSSALASLVSAPKIFQALCKDNIYPAFQMFAKGYGKNNEPLRGYILTFLIALGFILIAELNVI 674
            |||||||||||||||:|||||||.:||....|||||||||||:|||:|||:||..||||.|||:|
  Fly   533 ATLSSALASLVSAPKVFQALCKDELYPKIVWFAKGYGKNNEPVRGYVLTFIIACAFILIGELNLI 597

Human   675 APIISNFFLASYALINFSVFHASLAKSPGWRPAFKYYNMWISLLGAILCCIVMFVINWWAALLTY 739
            ||:|||||||:|.|||||.|||||||..||||.|||||||:||||||||..|||:|:|..||:|:
  Fly   598 APLISNFFLAAYMLINFSTFHASLAKPVGWRPTFKYYNMWLSLLGAILCVAVMFLISWATALITF 662

Human   740 VIVLGLYIYVTYKKPDVNWGSSTQALTYLNALQHSIRLSGVEDHVKNFRPQCLVMTGAPNSRPAL 804
            ..||.||:.|.|:||||||||:|||.||.|||....:|:.||:||||:|||.||::|.||:||.|
  Fly   663 AAVLALYLIVAYRKPDVNWGSTTQAQTYKNALMSVQQLNNVEEHVKNYRPQILVLSGLPNTRPVL 727

Human   805 LHLVHDFTKNVGLMICGHVHMGPRRQAMKEMSIDQAKYQRWLIKNKMKAFYAPVHADDLREGAQY 869
            :.|.:..|||:.|::||||..|...|  |..:..|.:...|..|:::|.|||.|..:|...|.:.
  Fly   728 VDLAYMLTKNLSLLVCGHVLKGSSSQ--KYRTYLQERAGNWFRKHRVKGFYALVDGEDFESGTRA 790

Human   870 LMQAAGLGRMKPNTLVLGFKKDWLQADMRDVDMYINLFHDAFDIQYGVVVIRLKEGLDISHLQGQ 934
            ||||.|:|::|||.:::|:|.||...|.:::|.|.|:.|.|.|:...|.::|:.:|||.|.:.|.
  Fly   791 LMQATGIGKLKPNIILMGYKTDWQTCDHKELDQYFNVMHKALDMYLSVAILRVPQGLDCSQVLGS 855

Human   935 EE----------LLSSQEKSPGTKDVVVSVEYSKKSDLDTSKPLSEKPITHKVEEED-------- 981
            ::          .|...|.|...:.|..||.......:|:        ::..|.:||
  Fly   856 QDGWKTVSDVPRTLQPNESSGDLQAVDSSVRNGLSGSIDS--------LSRNVSQEDRNRNQLVH 912

Human   982 -------------------------GKTATQPL------LKKESKGPIVPLNVADQKLLEAS--- 1012
                                     ..::|..|      ..|:..|...||:.....|:..|
  Fly   913 SEQNSLKIVKLRFKQGLRRMRSWPGAASSTSDLSFIAGNQSKDVSGMPDPLDAKSANLVSNSLRK 977

Human  1013 ----------------------------TQFQKKQGKNTIDVWWLFDDGGLTLLIPYLLTTKKKW 1049
                                        |||.:|:....||||||:||||||||:||:::|::.|
  Fly   978 SKLKHDDPASLYKGPGGAELPKEVLADLTQFTRKRSHAVIDVWWLYDDGGLTLLLPYIISTRRTW 1042

Human  1050 KDCKIRVF-IGGKINRIDHDRRAMATLLSKFRIDFSDIMVLGDINTKPKKENIIAFEEIIEPYRL 1113
            :.||:||: :..|.:.::.::|:||:||||||||:||:.::.||..||::.:...|.|:|:.:.:
  Fly  1043 QSCKLRVYALANKNSELEFEQRSMASLLSKFRIDYSDLTLIPDITKKPQETSTQFFNELIKDFVV 1107

Human  1114 HEDDKEQDIADK--MKEDEPWRITDNELELYKTKTYRQIRLNELLKEHSSTANIIVMSLPVARKG 1176
            .|.|.|...:.:  :.||:. .|||::|...:.||.|.:||.|.|:|.|:.::::||:||:.||.
  Fly  1108 TEKDGENGTSSRATLNEDDA-LITDDDLLAVQDKTNRYLRLREYLREQSTKSDLVVMTLPMPRKN 1171

Human  1177 AVSSALYMAWLEALSKDLPPILLVRGNHQSVLTFYS 1212
            .||:.|||||||:||:|:||.|.||||..|||||||
  Fly  1172 IVSAPLYMAWLESLSRDMPPFLFVRGNQTSVLTFYS 1207

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC12A2	NP_001037.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	36..81		3/15 (20%)
		RFXV motif 1. /evidence=ECO:0000269|PubMed:16669787	80..83		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	112..138		8/46 (17%)
		RFXV motif 2. /evidence=ECO:0000269|PubMed:16669787	138..141		1/2 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	150..193		7/42 (17%)
		2a30	216..1212	CDD:273347	518/1097 (47%)
		Scissor helix. /evidence=ECO:0000269|PubMed:35585053, ECO:0000269|PubMed:36306358, ECO:0007744|PDB:7MXO, ECO:0007744|PDB:7N3N, ECO:0007744|PDB:7S1X, ECO:0007744|PDB:7SFL, ECO:0007744|PDB:7SMP	761..778		8/16 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	962..989		5/59 (8%)
Ncc69	NP_001261758.1	AA_permease_2	155..1207	CDD:459263	518/1096 (47%)